Results 121 to 130 of about 1,502 (157)

Hematoporphyrin Derivative Therapy of Papillomas: Experimental Study

Archives of Otolaryngology - Head and Neck Surgery, 1986
Hematoporphyrin derivative has been shown to selectively localize in malignant tissues and chemically induced animal papillomas. It is a powerful photo-sensitizing agent that can cause destruction and death of tissues in which it has localized by the generation of singlet oxygen when activated by light of the appropriate wavelength (photodynamic ...
M J, Shikowitz, B M, Steinberg, A L, Abramson   +2 more
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A Chromatographic Study of Hematoporphyrin Derivatives

1984
Hematoporphyrin derivative (Hpd), a porphyrin mixture first introduced as a tumorlocalizer by Lipson et al. is the most widely used drug in clinical trials for photoradiation therapy (PRT) of cancer. Furthermore, due to its fluorescence and tumorlocalizing properties, it may be used in cancer diagnosis1–5.
Stein Sommer, Johan Moan, Terje Christensen, Jan F. Evensen   +3 more
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Two-step laser activation of hematoporphyrin derivative

Chemical Physics Letters, 1982
Abstract A new photoactivation mechanism of hematoporphyrin derivative is presented. This process, based on the sequential absorption of two photons, leads to the production of cytotoxic radicals of HpD. The cytocidal efficiency is demonstrated by in vitro experiments.
A. Andreoni, CUBEDDU, RINALDO, DE SILVESTRI, SANDRO, LAPORTA, PAOLO, SVELTO, ORAZIO   +4 more
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PHOTOSENSITIZING EFFECTS OF HEMATOPORPHYRIN DERIVATIVE IMMOBILIZED ON SEPHAROSE

Photochemistry and Photobiology, 1987
Abstract— The cytotoxicity that ensues following photosensitization by hematoporphyrin derivative (Hpd) is attributed to production of singlet oxygen. Many of the cellular end points reported to be affected are localized to membranes, hydrophobic environments conducive to partitioning of hydrophobic porphyrins in Hpd.
S L, Gibson, R S, Murant, R, Hilf
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Hematoporphyrin derivative: experimental evidence for aggregated species

Chemical Physics Letters, 1982
Abstract Absorption and fluorescence properties of hematoporphyrin derivative in different solvent systems are investigated. The presence of a large amount of stable aggregates is demonstrated. The existence of these aggregates represents one major difference between hematoporphyrin derivative and hematoporphyrin free base.
A. Andreoni, CUBEDDU, RINALDO, DE SILVESTRI, SANDRO, G. Jori, LAPORTA, PAOLO, E. Reddi   +5 more
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Membrane photosensitization by hematoporphyrin and hematoporphyrin derivative.

Progress in clinical and biological research, 1985
HPD-A, the putative active biologic component of HPD, photosensitized lysis of large phosphatidylcholine liposomes and lipid peroxidation in small liposomes with oxygen enhancement ratios from 4 to 5. Unambiguous proof was obtained that this damage was mediated by singlet oxygen.
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On the Preparation of Dihematoporphyrin Ether-Free Hematoporphyrin Derivative

Biological Chemistry Hoppe-Seyler, 1988
A dihematoporphyrin ether-free hematoporphyrin derivative has been prepared by a base-catalysed dehydration of hematoporphyrin with sodium hydroxide. The identification was performed by HPLC and mass spectroscopy (FD-MS). The reaction of hematoporphyrin with 1 M sodium hydroxide for 24 h yields more than 90% of the monomeric porphyrins.
H, Häberlein, P, Both, M O, Doss
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Uptake of the components of hematoporphyrin derivative by cells and tumours

Cancer Letters, 1983
The porphyrin content of cells labelled with hematoporhyrin derivative (Hpd) and tumours of mice injected with Hpd was analysed by means of high pressure liquid chromatography (HPLC). The components of Hpd may be classified in 3 groups: (A) Components with a high fluorescence quantum yield and with sharp peaks in the HPLC chromatogram.
J, Moan, S, Sommer
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Bactericidal Effects of Photoradiation Therapy With Hematoporphyrin Derivative

Journal of Infectious Diseases, 1985
Hematoporphyrin derivative (Hpd) localizes selectively in malignant and rapidly metabolizing tissues and undergoes a cytotoxic reaction when exposed to light of a specific wavelength. Hpd has been studied extensively with regard to the diagnosis and treatment of tumors but not with regard to bactericidal activity. This investigation assessed the effect
F R, Venezio, C, DiVincenzo, R, Sherman, M, Reichman, T C, Origitano, K, Thompson, O H, Reichman   +6 more
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Hematoporphyrin Derivative: Fluorometric Studies in Solution and Cells

1984
Hematoporphyrin Derivative (HpD) is a mixture of porphyrins, widely used in detection and therapy of cancer1,2. HpD was introduced in 1961 by Lipson et al.3 as a better tumor-locating drug than Hematoporphyrin (Hp). They proposed that the crude Hp be treated with a mixture of acetic acid and sulfuric acid, followed by adjustment of the final pH to ...
Giovanni Bottiroli, DOCCHIO, Franco, Isabel Freitas, Roberta Ramponi, Carlo A. Sacchi   +4 more
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