Results 11 to 20 of about 22,924 (125)

Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages.

JCI Insight, 2020
Tumor-Associated Macrophages (TAMs) contribute to the maintenance of a strong immunosuppressive environment, supporting tumor progression and resistance to treatment.
Emmanuelle Alaluf, B. Vokaer, A. Detavernier, Abdulkader Azouz, Marion Splittgerber, A. Carrette, L. Boon, F. Libert, M. Soares, A. Le Moine, S. Goriely   +10 more
semanticscholar   +1 more source

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the degradation of heme to carbon monoxide, iron, and biliverdin.
L. Dunn, S. Kong, S. Tumanov, Weiyu Chen, J. Cantley, Anita Ayer, G. Maghzal, R. G. Midwinter, K. Chan, M. Ng, R. Stocker   +10 more
semanticscholar   +1 more source

Expression and activity analysis reveal that heme oxygenase (decycling) 1 is associated with blue egg formation

Poultry Science, 2011
Biliverdin is responsible for the coloration of blue eggs and is secreted onto the eggshell by the shell gland. Previous studies confirmed that a significant difference exists in biliverdin content between blue eggs and brown eggs, although the reasons are still unknown.
Z P, Wang, R F, Liu, A R, Wang, J Y, Li, X M, Deng   +4 more
openaire   +2 more sources

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

Antioxidants, 2020
SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and show lung injury and hemolysis.
F. Wagener, P. Pickkers, S. Peterson, S. Immenschuh, N. Abraham   +4 more
semanticscholar   +1 more source

Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron

Cell Death and Disease, 2020
The consumption of red meat is probably carcinogenic to humans and is associated with an increased risk to develop colorectal cancer (CRC). Red meat contains high amounts of heme iron, which is thought to play a causal role in tumor formation.
Nina Seiwert, Sabine Wecklein, P. Demuth, Solveig Hasselwander, Talke A Kemper, T. Schwerdtle, T. Brunner, J. Fahrer   +7 more
semanticscholar   +1 more source

COVID-19 and heme oxygenase: novel insight into the disease and potential therapies

Cell stress & chaperones (Print), 2020
The COVID-19 pandemic needs therapies that are presently available and safe. We propose that subjects with metabolic syndrome, old age, and male gender have the greatest morbidity and mortality and have low stress proteins, in particular, low ...
P. Hooper
semanticscholar   +1 more source

Therapeutic Potential of Heme Oxygenase-1 and Carbon Monoxide in Acute Organ Injury, Critical Illness, and Inflammatory Disorders

Antioxidants, 2020
Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase.
S. Ryter
semanticscholar   +1 more source

Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease

International Journal of Molecular Sciences, 2020
Heme oxygenase (HO) is a critical component of the defense mechanism to a wide variety of cellular stressors. HO induction affords cellular protection through the breakdown of toxic heme into metabolites, helping preserve cellular integrity. Nonalcoholic
D. Stec, T. Hinds
semanticscholar   +1 more source

Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease

Antioxidants, 2020
Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent.
Jose D. Puentes-Pardo, Sara Moreno-SanJuan, Á. Carazo, J. León   +3 more
semanticscholar   +1 more source

Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways

Antioxidants, 2019
The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron.
J. Duvigneau, H. Esterbauer, Andrey V. Kozlov   +2 more
semanticscholar   +1 more source