Results 21 to 30 of about 22,924 (125)
Chinese Journal of Contemporary Neurology and Neurosurgery, 2011 Objective To investigate the relationship among the expressions of heme⁃oxygenase⁃1 (HO ⁃ 1), glial fibrillary acidic protein (GFAP) and cyclinD1 in the perihematomal tissues in human intracerebral hemorrhage (ICH) and brain renovation following ICH ...
Wenzhao WANG +5 more
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Antioxidants and Redox Signaling, 2019 Significance: Heme oxygenase-1 (HO-1) is a ubiquitous 32-kDa protein expressed in many tissues and highly inducible. They catalyze the degradation of the heme group and the release of free iron, carbon monoxide, and biliverdin; the latter converted to ...
María Victoria Medina +3 more
semanticscholar +1 more source
The Protective Role of Heme Oxygenase-1 in Atherosclerotic Diseases
International Journal of Molecular Sciences, 2019 Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin.
Y. Kishimoto, K. Kondo, Y. Momiyama
semanticscholar +1 more source
A Dual Role of Heme Oxygenase-1 in Cancer Cells
International Journal of Molecular Sciences, 2018 Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions.
Shih-Kai Chiang +2 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2019 The prevalence of vascular disorders continues to rise worldwide. Parallel with that, new pathophysiological pathways have been discovered, providing possible remedies for prevention and therapy in vascular diseases.
T. Gáll, G. Balla, J. Balla
semanticscholar +1 more source
Cell Death and Disease, 2019 Phenotypic changes of myeloid cells are critical to the regulation of premature aging, development of cancer, and responses to infection. Heme metabolism has a fundamental role in the regulation of myeloid cell function and activity.
Andreas Hedblom +7 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2018 Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response ...
M. Nitti +5 more
semanticscholar +1 more source
PLoS ONE, 2018 During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
J. Belcher +12 more
semanticscholar +1 more source
Heme oxygenase inhibition in cancers: possible tools and targets
Contemporary oncology, 2018 Heme oxygenase-1 (HO-1, encoded by HMOX1) through degradation of pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe2+) and biliverdin, exhibits cytoprotective, anti-apoptotic and anti-inflammatory properties. All of these potentially beneficial
P. Podkalicka +4 more
semanticscholar +1 more source
Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression
Frontiers in Immunology, 2018 Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450.
Valentina P. Sebastián +9 more
semanticscholar +1 more source