Evolutionary Pro-To-Thr Mutation in the Intrinsically Disordered Domain of ANP32 Family Members Modulates Their Target Binding Modes. [PDF]
Adv Sci (Weinh)Gene duplication has allowed protein evolution toward novel functions and mechanisms. The differences between paralogous genes frequently rely on the sequence of disordered regions.
Baños-Jaime B +8 more
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Molecules, 2020 Valorisation of industrial low-value waste residues was preconized. Hence, carbon dots (C-dots) were synthesized from wastewaters of the cork industry—an abundant and affordable, but environmentally-problematic industrial effluent.
Marta R. Alexandre +3 more
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Low levels of nitric oxide promotes heme maturation into several hemeproteins and is also therapeutic [PDF]
Redox Biology, 2022 Nitric oxide (NO) is a signal molecule and plays a critical role in the regulation of vascular tone, displays anti-platelet and anti-inflammatory properties.
Arnab Ghosh +8 more
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Hemeprotein Tpx1 interacts with cell‐surface heme transporter Str3 in Schizosaccharomyces pombe [PDF]
Molecular Microbiology, 2020 Str3 is a transmembrane protein that mediates low‐affinity heme uptake in Schizosaccharomyces pombe. Under iron‐limiting conditions, Str3 remains at the cell surface in the presence of increasing hemin concentrations.
Vincent Normant +6 more
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Regulation of the expression of ferrochelatase in a murine model of diabetes mellitus type I [PDF]
Biochemistry and Biophysics ReportsBackground: Diabetes produces changes on cellular hemeprotein metabolism. The last enzyme of heme biosynthetic pathway is ferrochelatase (FECH), an enzyme that catalyzes the insertion of ferrous ion into protoporphyrin IX to produce heme. The aim of this
Leda María Oliveri +2 more
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Improved method for assembly of hemeprotein neuronal NO-synthase heterodimers [PDF]
Analytical Biochemistry, 2016 The assembly of mutated and wild type monomers into functional heterodimeric hemeproteins has provided important mechanistic insights. As in the case of NO synthase (NOS), the existing methods to make such heterodimeric NOSs are inefficient and labor intensive with typical yields of about 5%.
Yoshihiro, Morishima +3 more
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Site-directed Mutagenesis of Cytochromec 6 from Anabaena Species PCC 7119 [PDF]
Journal of Biological Chemistry, 1999 A number of surface residues of cytochromec 6 from the cyanobacterium Anabaenasp. PCC 7119 have been modified by site-directed mutagenesis. Changes were made in six amino acids, two near the heme group (Val-25 and Lys-29) and four in the positively ...
Díaz Quintana, Antonio Jesús +4 more
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Assimilatory Nitrate Reductase of Rhodopseudomonas capsulata AD2: A Molybdo-Hemeprotein [PDF]
Zeitschrift fur Naturforschung. Section C, Biosciences, 1979 The assimilatory nitrate reductase of the phototrophic bacterium Rhodopseudomonas capsulata strain AD2 was purified to homogeneity by a combination of ammonium sulfate fractionation, chromatography on DEAE-cellulose and isoelectric focusing (isoelectric ...
Kasem Alef, Jobst-Heinrich Klemme
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Influence of the freezing process upon fluoride binding to hemeproteins
Biophysical Journal, 1991 Fluoride association with ferric myoglobins and hemoglobins in aqueous buffers above freezing has been well studied. We chose this reaction to investigate the feasibility of observing titration intermediates and estimating dissociation constants at the freezing temperature by electron paramagnetic resonance spectroscopy at cryogenic temperatures ...
Yang, A.S., Brill, A.S.
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Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells [PDF]
Scientific ReportsNeuroglobin (NGB) is a hexacoordinated hemeprotein mainly expressed in neurons. Following its upregulation and mitochondrial localization, NGB plays a pro-survival role against neuronal stress.
Valeria Manganelli +12 more
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