New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals
Biological chemistry, 2022 The intracellular trafficking of mitochondrial heme presents a fundamental challenge to animal cells. This article provides some background on heme allocation, discusses some of the concepts, and then reviews research done over the last decade, much in ...
D. Stuehr +4 more
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Hydrogen Sulfide and Hemeproteins: Knowledge and Mysteries [PDF]
Antioxidants & Redox Signaling, 2010 Historically, hydrogen sulfide (H(2)S) has been regarded as a poisonous gas, with a wide spectrum of toxic effects. However, like ·NO and CO, H(2)S is now referred to as a signaling gas involved in numerous physiological processes. The list of reports highlighting the physiological effects of H(2)S is rapidly expanding and several drug candidates are ...
Ruth Pietri +2 more
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Ligand migration through hemeprotein cavities: insights from laser flash photolysis and molecular dynamics simulations [PDF]
Physical Chemistry, Chemical Physics - PCCP, 2013 Stefania Abbruzzetti +4 more
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Angewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023 Computational modelling was employed to rationally guide protein engineering toward controlling the accessible conformations of a key lactone‐carbene (LAC) intermediate in the enzyme active site by installing a new H‐bond anchoring point. This H‐bonding interaction controls the relative orientation of the fleeting carbene intermediate, orienting it for
Carla Calvó‐Tusell +4 more
wiley +2 more sources
Nanomaterials, 2023 Hemeprotein detection has motivated extensive research on the direct reaction of a heme molecule and a redox dye. The present study used methylene blue as both donor and acceptor for a redox reaction.
Porntip Khownarumit +5 more
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Hydrogen Peroxide-Dependent Formation and Bleaching of the Higher Oxidation States of Bovine Erythrocyte Green Hemeprotein [PDF]
Archives of Biochemistry and Biophysics, 1993 Feng Xu +3 more
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Chemoselective Caging of Carboxyl Groups for On‐Demand Protein Activation with Small Molecules
Angewandte Chemie, Volume 135, Issue 22, May 22, 2023., 2023 The caging of amino acid side chains can provide exquisite control of protein function. The first chemical caging of carboxyl groups (Asp and Glu) in enzymic active sites is reported. Caging of a heme propionate in a protein was also feasible by this approach based on esterification with a tuned diazo compound.
Yana D. Petri +2 more
wiley +2 more sources
Spectral Studies of Iron Coordination in Hemeprotein Complexes
Biophysical Journal, 1968 Arthur S. Brill, Howard E. Sandberg
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Hyperfine Correlation Spectroscopy and Electron Spin Echo Envelope Modulation Spectroscopy Study of the Two Coexisting Forms of the Hemeprotein Cytochrome c6 from Anabaena Pcc7119 [PDF]
Biophysical Journal, 2008 Inés García‐Rubio +3 more
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