Results 31 to 40 of about 2,605 (236)

Phosphorylation of cytochrome c at tyrosine 48 finely regulates its binding to the histone chaperone SET/TAF-Iβ in the nucleus. [PDF]

open access: yesProtein Sci
Abstract Post‐translational modifications (PTMs) of proteins are ubiquitous processes present in all life kingdoms, involved in the regulation of protein stability, subcellular location and activity. In this context, cytochrome c (Cc) is an excellent case study to analyze the structural and functional changes induced by PTMS as Cc is a small ...
Tamargo-Azpilicueta J   +7 more
europepmc   +2 more sources

Behind the Optimization of the Sensor Film: Bioconjugation of Triangular Gold Nanoparticles with Hemoproteins for Sensitivity Enhancement of Enzymatic Biosensors

open access: yesBiosensors, 2023
Electrochemical biosensors are widely used in a multitude of applications, such as medical, nutrition, research, among other fields. These sensors have been historically used and have not undergone many changes in terms of the involved electrochemical ...
Miriam Chávez   +6 more
doaj   +1 more source

Inside Cover: De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four‐Helix Bundle Hemeprotein (Chem. Eur. J. 50/2012) [PDF]

open access: bronze, 2012
Marina Faiella   +6 more
openalex   +2 more sources

Reversing the Enantioselectivity of Enzymatic Carbene N−H Insertion Through Mechanism‐Guided Protein Engineering**

open access: yesAngewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023
Computational modelling was employed to rationally guide protein engineering toward controlling the accessible conformations of a key lactone‐carbene (LAC) intermediate in the enzyme active site by installing a new H‐bond anchoring point. This H‐bonding interaction controls the relative orientation of the fleeting carbene intermediate, orienting it for
Carla Calvó‐Tusell   +4 more
wiley   +2 more sources

The Effect of 5-Aminolevulinic Acid on Cytochrome P450-Mediated Prodrug Activation. [PDF]

open access: yesPLoS ONE, 2015
Of late, numerous prodrugs are widely used for therapy. The hemeprotein cytochrome P450 (CYP) catalyzes the activation of prodrugs to form active metabolites.
Mai Miura   +5 more
doaj   +1 more source

Tracking Heme-Protein Interactions in Healthy and Pathological Human Serum in Native Conditions by Miniaturized FFF-Multidetection

open access: yesApplied Sciences, 2022
The interaction of heme with blood serum proteins plays an important role in many physiological and pathological processes involving enzyme activity, gene expression and cell proliferation.
Valentina Marassi   +4 more
doaj   +1 more source

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [PDF]

open access: yes, 2020
An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation.
Chudasama, V.   +6 more
core   +1 more source

CYP116B5hd, a self-sufficient P450 cytochrome: A dataset of its electronic and geometrical properties

open access: yesData in Brief, 2022
This paper documents the dataset obtained from the Electron Paramagnetic Resonance (EPR) study of the electronic properties of a self-sufficient cytochrome P450, CYP116B5hd, which possesses an interesting catalytic activity for synthetic purposes.
Antonino Famulari   +5 more
doaj   +1 more source

Spectral Studies of Iron Coordination in Hemeprotein Complexes

open access: yesBiophysical Journal, 1968
Brill, Arthur S., Sandberg, Howard E.
openaire   +2 more sources

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