Results 31 to 40 of about 2,618 (230)
The Histone Chaperones SET/TAF-1β and NPM1 Exhibit Conserved Functionality in Nucleosome Remodeling and Histone Eviction in a Cytochrome c-Dependent Manner. [PDF]
Adv Sci (Weinh), 2023 This study focuses on the molecular action of two histone chaperones: SET/template‐activating factor‐Iβ and nucleophosmin 1. It is shown how these chaperones have specificity for fully dismantled nucleosomes, characterized the histone eviction (removal) process, and its modulation by cytochrome c.
Buzón P +5 more
europepmc +2 more sources
Biomimetic chemistry of hemeproteins.
The Keio Journal of Medicine, 1989 Hemeproteins play important physiological roles for an oxygen metabolism in living organisms. Their functions are divided to three main groups, i) hemoglobins, myoglobins and the cytochromes which function by transporting and storing dioxygen and electrons; ii) catalase and peroxidases which are activated by hydrogen peroxide, iii) cytochrome oxidase ...
David Dolphin
openalex +5 more sources
Phosphorylation of cytochrome c at tyrosine 48 finely regulates its binding to the histone chaperone SET/TAF-Iβ in the nucleus. [PDF]
Protein SciAbstract Post‐translational modifications (PTMs) of proteins are ubiquitous processes present in all life kingdoms, involved in the regulation of protein stability, subcellular location and activity. In this context, cytochrome c (Cc) is an excellent case study to analyze the structural and functional changes induced by PTMS as Cc is a small ...
Tamargo-Azpilicueta J +7 more
europepmc +2 more sources
Mechanism of Sulfide Binding by Ferric Hemeproteins [PDF]
Inorganic Chemistry, 2018 The reaction of hydrogen sulfide (H2S) with hemeproteins is a key physiological reaction; still, its mechanism and implications are not completely understood. In this work, we propose a combination of experimental and theoretical tools to shed light on the reaction in model system microperoxidase 11 (MP11-FeIII) and myoglobin (Mb-FeIII), from the ...
Fernando M. Boubeta +5 more
openalex +5 more sources
Hydrogen Sulfide and Hemeproteins: Knowledge and Mysteries [PDF]
Antioxidants & Redox Signaling, 2010 Historically, hydrogen sulfide (H(2)S) has been regarded as a poisonous gas, with a wide spectrum of toxic effects. However, like ·NO and CO, H(2)S is now referred to as a signaling gas involved in numerous physiological processes. The list of reports highlighting the physiological effects of H(2)S is rapidly expanding and several drug candidates are ...
Ruth Pietri +2 more
openalex +4 more sources
Journal of Biological Chemistry, 1992 I. A. Pikuleva, Anna Lapko, V. Chashchin
semanticscholar +2 more sources
Angewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023 Computational modelling was employed to rationally guide protein engineering toward controlling the accessible conformations of a key lactone‐carbene (LAC) intermediate in the enzyme active site by installing a new H‐bond anchoring point. This H‐bonding interaction controls the relative orientation of the fleeting carbene intermediate, orienting it for
Carla Calvó‐Tusell +4 more
wiley +2 more sources
The Reactions of Antibodies with Hemeprotein Antigens
, 1969 R. Noble, M. Reichlin, Q. H. Gibson
semanticscholar +2 more sources