Results 51 to 60 of about 2,605 (236)
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48 [PDF]
, 2017 Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies such as ischemia and cancer.
Conte, Rebecca del +7 more
core +4 more sources
Hydrogen sulfide activation in hemeproteins: The sulfheme scenario [PDF]
Journal of Inorganic Biochemistry, 2014 Traditionally known as a toxic gas, hydrogen sulfide (H2S) is now recognized as an important biological molecule involved in numerous physiological functions. Like nitric oxide (NO) and carbon monoxide (CO), H2S is produced endogenously in tissues and cells and can modulate biological processes by acting on target proteins.
Bessie B, Ríos-González +3 more
openaire +2 more sources
Factors Controlling the Reactivity of Hydrogen Sulfide with Hemeproteins [PDF]
Biochemistry, 2009 Hemoglobin I (HbI) from the clam Lucina pectinata is an intriguing hemeprotein that binds and transports H(2)S to sulfide-oxidizing chemoautotrophic bacteria to maintain a symbiotic relationship and to protect the mollusk from H(2)S toxicity. Single point mutations at E7, B10, and E11 were introduced into the HbI heme pocket to define the reactivity of
Ruth, Pietri +9 more
openaire +2 more sources
Influence of Saccharides on the Stabilization of Frozen Hemeprotein.
, 1998 Masatoshi IZUMIMOTO, Yongning Zhu
openalex +3 more sources
Hemoglobin I from Lucina pectinata on Collagen Scaffold: A Prospective Hydrogen Sulfide Scavenger
Journal of Chemistry, 2022 Hydrogen sulfide (H2S), independently of being a toxic gas with a characteristic smell of rotten eggs, is a crucial signaling molecule with significant physiological functions.
Jennifer Vargas Santiago +2 more
doaj +1 more source
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species
Oncogenesis, 2022 Pancreatic cancer is a highly challenging malignancy with extremely poor prognosis. Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is expressed in pericytes of all organs.
Dinh Viet Hoang +17 more
doaj +1 more source
Resonance Raman Spectroscopy of the Oxygenated Intermediates of Human CYP19A1 Implicates a Compound I Intermediate in the Final Lyase Step [PDF]
, 2014 CYP19A1, or aromatase, a cytochrome P450 responsible for estrogen biosynthesis in humans, is an important therapeutic target for the treatment of breast cancer.
Kincaid, James R. +3 more
core +2 more sources
The Reactions of Antibodies with Hemeprotein Antigens
Journal of Biological Chemistry, 1969 R W Noble, M Reichlin, Q H Gibson
openaire +2 more sources
Nature Communications, 2019 Myoglobin is a hemeprotein that reversibly binds oxygen and gives muscle its red color. Here, the authors report a genetic variant in the MB gene that associates with myoglobinopathy, an autosomal dominant progressive myopathy, and altered oxygen binding
Montse Olivé +43 more
doaj +1 more source