Results 61 to 70 of about 1,725 (195)

Porphyrin Atropisomerism as a Molecular Engineering Tool in Medicinal Chemistry, Molecular Recognition, Supramolecular Assembly, and Catalysis

Chemistry – A European Journal, Volume 30, Issue 43, August 1, 2024.
Porphyrin atropisomerism opens an entirely new toolbox, allowing for the precise design of a porphyrin's molecular shape. This review details how this phenomenon has been utilised across all fields of chemistry, focusing on molecular recognition, medicinal chemistry and catalysis.
Sophie Maguire, Grant Strachan, Karolis Norvaiša, Claire Donohoe, Lígia C. Gomes‐da‐Silva, Mathias O. Senge   +5 more
wiley   +1 more source

CYP116B5hd, a self-sufficient P450 cytochrome: A dataset of its electronic and geometrical properties

Data in Brief, 2022
This paper documents the dataset obtained from the Electron Paramagnetic Resonance (EPR) study of the electronic properties of a self-sufficient cytochrome P450, CYP116B5hd, which possesses an interesting catalytic activity for synthetic purposes.
Antonino Famulari, Danilo Correddu, Giovanna Di Nardo, Gianfranco Gilardi, Mario Chiesa, Inés García-Rubio   +5 more
doaj  

The flavohemoglobin Yhb1 is a new interacting partner of the heme transporter Str3

Molecular Microbiology, Volume 122, Issue 1, Page 29-49, July 2024.
A new mechanism for Yhb1 (orange) heme‐dependent activation involves direct interaction with the cell‐surface heme transporter Str3 (blue) in the presence of exogenous heme (red). Upon exposure to nitric oxide (˙NO), the expression of yhb1+ is induced, as its promoter is liberated from Fep1 repression (violet).
Florie Lo Ying Ping, Tobias Vahsen, Ariane Brault, Raphaël Néré, Simon Labbé   +4 more
wiley   +1 more source

Fungal systems for lignocellulose deconstruction: From enzymatic mechanisms to hydrolysis optimization

GCB Bioenergy, Volume 16, Issue 5, May 2024.
Biomass contains complex sugars and aromatic polymers that have the potential to serve as sustainable alternatives to fossil fuels and chemicals. Fungi possess specialized enzyme systems capable of breaking down lignocellulose into fermentable building blocks. This review analyses recent advancements in intricate fungal decomposition toolkits, shedding
Fengyun Ren, Fan Wu, Xin Wu, Tongtong Bao, Yucheng Jie, Le Gao   +5 more
wiley   +1 more source

Cultivating the uncultured: Harnessing the “sandwich agar plate” approach to isolate heme‐dependent bacteria from marine sediment

mLife, Volume 3, Issue 1, Page 143-155, March 2024.
Abstract In the classical microbial isolation technique, the isolation process inevitably destroys all microbial interactions and thus makes it difficult to culture the many microorganisms that rely on these interactions for survival. In this study, we designed a simple coculture technique named the “sandwich agar plate method,” which maintains ...
Jing Zhang, Qi‐Yun Liang, Da‐Shuai Mu, Fengbai Lian, Ya Gong, Mengqi Ye, Guan‐Jun Chen, Yuqi Ye, Zong‐Jun Du   +8 more
wiley   +1 more source

Perioperative intravenous acetaminophen attenuates lipid peroxidation in adults undergoing cardiopulmonary bypass: a randomized clinical trial.

PLoS ONE, 2015
BackgroundCardiopulmonary bypass (CPB) lyses erythrocytes and induces lipid peroxidation, indicated by increasing plasma concentrations of free hemoglobin, F2-isoprostanes, and isofurans.
Frederic T Billings, Michael R Petracek, L Jackson Roberts, Mias Pretorius   +3 more
doaj   +1 more source

Mechanistics of pH‐Dependent Sulfmyoglobin Formation: Spin Control and His64 Proton Relay

Journal of Chemistry, Volume 2024, Issue 1, 2024.
The chemistry of hydrogen sulfide (H2S) has been directed towards physiologically relevant hemeproteins, including myoglobin, hemoglobin, and other similar proteins. Despite substantial efforts, there remains a need to elucidate the mechanism and identify the species involved in the reaction between oxy‐hemeproteins and H2S. Here, we summarize both our
Angel D. Rodriguez-Mackenzie, Lysmarie Santos-Velazquez, Héctor D. Arbelo-Lopez, Troy Wymore, Juan Lopez-Garriga, Jose Corchado   +5 more
wiley   +1 more source

Influence of the freezing process upon fluoride binding to hemeproteins [PDF]

Biophysical Journal, 1991
Fluoride association with ferric myoglobins and hemoglobins in aqueous buffers above freezing has been well studied. We chose this reaction to investigate the feasibility of observing titration intermediates and estimating dissociation constants at the freezing temperature by electron paramagnetic resonance spectroscopy at cryogenic temperatures ...
An-Suei Yang, Arthur S. Brill
openaire   +2 more sources

Exploring protein phosphorylation by combining computational approaches and biochemical methods

Computational and Structural Biotechnology Journal, 2020
Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a variety of stimuli. Among these modifications, phosphorylation is the most ubiquitous and plays a prominent role in cell signaling.
Gonzalo Pérez-Mejías, Alejandro Velázquez-Cruz, Alejandra Guerra-Castellano, Blanca Baños-Jaime, Antonio Díaz-Quintana, Katiuska González-Arzola, Miguel Ángel De la Rosa, Irene Díaz-Moreno   +7 more
doaj  

Heme Spin Distribution in the Substrate-Free and Inhibited Novel CYP116B5hd: A Multifrequency Hyperfine Sublevel Correlation (HYSCORE) Study

Molecules
The cytochrome P450 family consists of ubiquitous monooxygenases with the potential to perform a wide variety of catalytic applications. Among the members of this family, CYP116B5hd shows a very prominent resistance to peracid damage, a property that ...
Antonino Famulari, Danilo Correddu, Giovanna Di Nardo, Gianfranco Gilardi, George Mitrikas, Mario Chiesa, Inés García-Rubio   +6 more
doaj   +1 more source