Results 71 to 80 of about 2,605 (236)

Ferricytochrome c Directly Oxidizes Aminoacetone to Methylglyoxal, a Catabolite Accumulated in Carbonyl Stress [PDF]

, 2013
Age-related diseases are associated with increased production of reactive oxygen and carbonyl species such as methylglyoxal. Aminoacetone, a putative threonine catabolite, is reportedly known to undergo metal-catalyzed oxidation to methylglyoxal, NH4 ...
Bechara, Etelvino José Henriques, Dyszy, Fabio H., Mano, Camila M., Mantovani, Mariana C., Massari, Julio, Nantes, Iseli L., Nascimento, Otaciro R., Sartori, Adriano, Tokikawa, Rita   +8 more
core   +2 more sources

Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells [PDF]

, 2003
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes of O2 tension are unknown.
García Fernández, María, López Barneo, José, Ortega Sáenz, Patricia, Pardal Redondo, Ricardo   +3 more
core   +2 more sources

Conformational Dependence of a Protein Kinase Phosphate Transfer Reaction

, 2004
Atomic motions and energetics for a phosphate transfer reaction catalyzed by the cAMP-dependent protein kinase (PKA) are calculated by plane-wave density functional theory, starting from structures of proteins crystallized in both the reactant ...
Austin, B. H. McMahon, C.-S. Tung, Cheng, Clementi, Frauenfelder, Frauenfelder, G. Henkelman, Hanggi, Johnson, Johnson, M. X. LaBute, Madhusudan, McMahon, N  meth, P. W. Fenimore, Pearson, Pinna, Smith, Songyang, Valiev, Yang, Zheng   +22 more
core   +2 more sources

Acetylated Epigallocatechin Gallate and Ascorbyl Palmitate: Comparative Study on Antioxidant Activity and Retardation of Lipid Oxidation in Fish Mince and Shrimp Oil

Journal of Food Science, Volume 90, Issue 10, October 2025.
ABSTRACT Antioxidant activities of acetylated epigallocatechin gallate (A‐EGCG) and ascorbyl palmitate (AP) were compared using different in vitro assays and food model systems. Both A‐EGCG and AP exhibited DPPH and ABTS radical scavenging activities and reducing power. AP demonstrated greater scavenging efficacy toward both radicals than A‐EGCG (p < 0.
Bharathipriya Rajasekaran, Min‐Hsiung Pan, Natchaphol Buamard, Bin Zhang, Jun Tae Kim, Soottawat Benjakul   +5 more
wiley   +1 more source

BioSuper: A web tool for the superimposition of biomolecules and assemblies with rotational symmetry [PDF]

, 2014
Background Most of the proteins in the Protein Data Bank (PDB) are oligomeric complexes consisting of two or more subunits that associate by rotational or helical symmetries.
Abagyan, Ruben, Orozco López, Modesto, Rueda Borrego, Manuel, Totrov, Maxim   +3 more
core   +2 more sources

Biomimetic chemistry of hemeproteins.

The Keio Journal of Medicine, 1989
Hemeproteins play important physiological roles for an oxygen metabolism in living organisms. Their functions are divided to three main groups, i) hemoglobins, myoglobins and the cytochromes which function by transporting and storing dioxygen and electrons; ii) catalase and peroxidases which are activated by hydrogen peroxide, iii) cytochrome oxidase ...
openaire   +3 more sources

Development of Bioorthogonally Degradable Tough Hydrogels Using Enamine N‐Oxide Based Crosslinkers

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
Inducibly degradable enamine N‐oxide crosslinkers are integrated into tough double network hydrogels, enabling rapid and bioorthogonal degradation by aqueous diboron solutions. These chemical reagent‐responsive biomaterials maintain structural integrity during use while enabling rapid degradation when needed, making them ideal for applications in ...
Thomas T. Kim, Deep Malu, Dongjing He, Yuhang Hu, Justin Kim   +4 more
wiley   +1 more source

Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]

, 2015
SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas, Andreas Daiber, Antonio Cuadrado, Brunner HG, Fabio Di Lisa, Ghassan J. Maghzal, Hampton MB, Harald H.H.W. Schmidt, Hou YC, Karl H. Krause, Klebanoff SJ., Liu VW, Manuela G. López, Nina Kaludercic, Pietro Ghezzi, Roland Stocker, Sandler M, Savenkova ML, Sonia Leach, Tamara Seredenina, V. Thao-Vi Dao, Vincent Jaquet   +21 more
core   +3 more sources

Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis [PDF]

, 2019
A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control precisely where a reaction takes place. Here we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C‒H amidation ...
Arnold, Frances H., Cho, Inha, Jia, Zhi-Jun   +2 more
core  

Application of Brownian motion theory to the analysis of membrane channel ionic trajectories calculated by molecular dynamics [PDF]

, 1988
This paper shows how Brownian motion theory can be used to analyze features of individual ion trajectories in channels as calculated by molecular dynamics, and that its use permits more precise determinations of diffusion coefficients than would ...
Aalfs, Cora M., de Geus, Eveline, de Haes, Hanneke C. J. M., Menko, Fred H., Sijmons, Rolf H., Smets, Ellen M. A., Verdam, Mathilde G. E.   +6 more
core   +2 more sources