Results 71 to 80 of about 1,942 (200)

Development of Bioorthogonally Degradable Tough Hydrogels Using Enamine N‐Oxide Based Crosslinkers

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
Inducibly degradable enamine N‐oxide crosslinkers are integrated into tough double network hydrogels, enabling rapid and bioorthogonal degradation by aqueous diboron solutions. These chemical reagent‐responsive biomaterials maintain structural integrity during use while enabling rapid degradation when needed, making them ideal for applications in ...
Thomas T. Kim, Deep Malu, Dongjing He, Yuhang Hu, Justin Kim   +4 more
wiley   +1 more source

Hydrogen sulfide activation in hemeproteins: The sulfheme scenario [PDF]

Journal of Inorganic Biochemistry, 2014
Traditionally known as a toxic gas, hydrogen sulfide (H2S) is now recognized as an important biological molecule involved in numerous physiological functions. Like nitric oxide (NO) and carbon monoxide (CO), H2S is produced endogenously in tissues and cells and can modulate biological processes by acting on target proteins.
Juan López-Garriga, Bessie B. Ríos-González, Elddie M. Roman-Morales, Ruth Pietri   +3 more
openaire   +3 more sources

Phosphorylation of cytochrome c at tyrosine 48 finely regulates its binding to the histone chaperone SET/TAF‐Iβ in the nucleus

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Post‐translational modifications (PTMs) of proteins are ubiquitous processes present in all life kingdoms, involved in the regulation of protein stability, subcellular location and activity. In this context, cytochrome c (Cc) is an excellent case study to analyze the structural and functional changes induced by PTMS as Cc is a small ...
Joaquin Tamargo‐Azpilicueta, Miguel Á. Casado‐Combreras, Rafael L. Giner‐Arroyo, Adrián Velázquez‐Campoy, Inmaculada Márquez, José L. Olloqui‐Sariego, Miguel A. De la Rosa, Irene Diaz‐Moreno   +7 more
wiley   +1 more source

Porphyrin Atropisomerism as a Molecular Engineering Tool in Medicinal Chemistry, Molecular Recognition, Supramolecular Assembly, and Catalysis

Chemistry – A European Journal, Volume 30, Issue 43, August 1, 2024.
Porphyrin atropisomerism opens an entirely new toolbox, allowing for the precise design of a porphyrin's molecular shape. This review details how this phenomenon has been utilised across all fields of chemistry, focusing on molecular recognition, medicinal chemistry and catalysis.
Sophie Maguire, Grant Strachan, Karolis Norvaiša, Claire Donohoe, Lígia C. Gomes‐da‐Silva, Mathias O. Senge   +5 more
wiley   +1 more source

Perioperative intravenous acetaminophen attenuates lipid peroxidation in adults undergoing cardiopulmonary bypass: a randomized clinical trial.

PLoS ONE, 2015
BackgroundCardiopulmonary bypass (CPB) lyses erythrocytes and induces lipid peroxidation, indicated by increasing plasma concentrations of free hemoglobin, F2-isoprostanes, and isofurans.
Frederic T Billings, Michael R Petracek, L Jackson Roberts, Mias Pretorius   +3 more
doaj   +1 more source

Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis [PDF]

, 2019
A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control precisely where a reaction takes place. Here we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C‒H amidation ...
Arnold, Frances H., Cho, Inha, Jia, Zhi-Jun   +2 more
core  

The flavohemoglobin Yhb1 is a new interacting partner of the heme transporter Str3

Molecular Microbiology, Volume 122, Issue 1, Page 29-49, July 2024.
A new mechanism for Yhb1 (orange) heme‐dependent activation involves direct interaction with the cell‐surface heme transporter Str3 (blue) in the presence of exogenous heme (red). Upon exposure to nitric oxide (˙NO), the expression of yhb1+ is induced, as its promoter is liberated from Fep1 repression (violet).
Florie Lo Ying Ping, Tobias Vahsen, Ariane Brault, Raphaël Néré, Simon Labbé   +4 more
wiley   +1 more source

Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]

, 2015
SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas, Andreas Daiber, Antonio Cuadrado, Brunner HG, Fabio Di Lisa, Ghassan J. Maghzal, Hampton MB, Harald H.H.W. Schmidt, Hou YC, Karl H. Krause, Klebanoff SJ., Liu VW, Manuela G. López, Nina Kaludercic, Pietro Ghezzi, Roland Stocker, Sandler M, Savenkova ML, Sonia Leach, Tamara Seredenina, V. Thao-Vi Dao, Vincent Jaquet   +21 more
core   +2 more sources

Fungal systems for lignocellulose deconstruction: From enzymatic mechanisms to hydrolysis optimization

GCB Bioenergy, Volume 16, Issue 5, May 2024.
Biomass contains complex sugars and aromatic polymers that have the potential to serve as sustainable alternatives to fossil fuels and chemicals. Fungi possess specialized enzyme systems capable of breaking down lignocellulose into fermentable building blocks. This review analyses recent advancements in intricate fungal decomposition toolkits, shedding
Fengyun Ren, Fan Wu, Xin Wu, Tongtong Bao, Yucheng Jie, Le Gao   +5 more
wiley   +1 more source

Study On Traditional Medicine-modern Drug Interaction And Its Molecular Mechanism Elucidation In Rat Liver [PDF]

, 1998
Traditional medicines have been used for thousands of years in maintaining health as an alternative to or in conjunction with modem medicines. Ubatan tradisional telah digunakan beribu-ribu tahun untuk penjagaan kesihatan sebagai alternatif atau ...
A. Taher, Yousef
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