Results 51 to 60 of about 3,392 (222)

The Urea Cycle in Connection to Polyamine Metabolism in Higher Plants: New Perspectives on a Central Pathway

Physiologia Plantarum, Volume 177, Issue 3, May/June 2025.
ABSTRACT The ornithine‐urea cycle is a biochemical pathway primarily found in animals, where it plays a crucial role in the re‐assimilation of ammonium and the removal of excess nitrogen in the form of urea. In lower photosynthetic eukaryotes, it contributes to metabolic responses during episodes of high nitrogen availability.
J. Buezo, M. Urra, E. M. González, R. Alcázar, D. Marino, J. F. Moran   +5 more
wiley   +1 more source

Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium : Evidence for gene duplications and extensive gene clustering

BMC Genomics, 2005
Background Phanerochaete chrysosporium, the model white rot basidiomycetous fungus, has the extraordinary ability to mineralize (to CO2) lignin and detoxify a variety of chemical pollutants.
Yadav Jagjit S, Chakraborty Ranajit, Doddapaneni Harshavardhan   +2 more
doaj   +1 more source

Biomimetic chemistry of hemeproteins.

The Keio Journal of Medicine, 1989
Hemeproteins play important physiological roles for an oxygen metabolism in living organisms. Their functions are divided to three main groups, i) hemoglobins, myoglobins and the cytochromes which function by transporting and storing dioxygen and electrons; ii) catalase and peroxidases which are activated by hydrogen peroxide, iii) cytochrome oxidase ...
openaire   +3 more sources

Development of Bioorthogonally Degradable Tough Hydrogels Using Enamine N‐Oxide Based Crosslinkers

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
Inducibly degradable enamine N‐oxide crosslinkers are integrated into tough double network hydrogels, enabling rapid and bioorthogonal degradation by aqueous diboron solutions. These chemical reagent‐responsive biomaterials maintain structural integrity during use while enabling rapid degradation when needed, making them ideal for applications in ...
Thomas T. Kim, Deep Malu, Dongjing He, Yuhang Hu, Justin Kim   +4 more
wiley   +1 more source

Density functional theory in transition-metal chemistry: a self-consistent Hubbard U approach

, 2006
Transition-metal centers are the active sites for many biological and inorganic chemical reactions. Notwithstanding this central importance, density-functional theory calculations based on generalized-gradient approximations often fail to describe ...
C. Rovira, Damian A. Scherlis, Heather J. Kulik, Hollas, Matteo Cococcioni, Nicola Marzari   +5 more
core   +1 more source

Evolutionary Pro‐To‐Thr Mutation in the Intrinsically Disordered Domain of ANP32 Family Members Modulates Their Target Binding Modes

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Protein evolution usually lies on mutations at disordered domains to promote novel functions and regulations. Here it is demonstrated that this is the case of ANP32A and ANP32B, two paralogs with apparently similar structures and functions, where a single amino‐acid substitution in the disordered domain triggers the extended‐to‐compact conformational ...
Blanca Baños‐Jaime, Ana B. Uceda‐Mayo, Francisco Rivero‐Rodríguez, Miguel Á. Casado‐Combreras, Alejandro Velázquez‐Cruz, Adrián Velázquez‐Campoy, Laura Corrales‐Guerrero, Miguel A. De la Rosa, Irene Díaz‐Moreno   +8 more
wiley   +1 more source

Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction

Antioxidants
Nitric oxide (NO) synthesis, signaling, and scavenging is associated to relevant physiological and pathological events. In all tissues and organs, NO levels and related functions are regulated at different levels, with heme proteins playing pivotal roles.
Giovanna De Simone, Alessandra di Masi, Diego Sbardella, Paolo Ascenzi, Massimiliano Coletta   +4 more
doaj   +1 more source

Maleimide-functionalised platinum(IV) complexes as synthetic platform for targeted drug delivery [PDF]

, 2013
Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for binding of thiol-containing tumour targeting molecules like human serum ...
Ang, Baban, Barnes, Bernhard K. Keppler, Carr, Carr, Choy, Christian R. Kowol, Dhar, Dhar, Diana Groza, Feazell, Frei, Galanski, Gerrit Hermann, Grek, Gunda Köllensperger, Heffeter, Josef Mayr, Jungwirth, Kratz, Kratz, Markus Galanksi, Miele, Orsolya Dömötör, Petra Heffeter, Pichler, Reithofer, Verena Pichler, Walter Berger, Wexselblatt, Wheate, Éva A. Enyedy   +32 more
core   +1 more source

Phosphorylation of cytochrome c at tyrosine 48 finely regulates its binding to the histone chaperone SET/TAF‐Iβ in the nucleus

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Post‐translational modifications (PTMs) of proteins are ubiquitous processes present in all life kingdoms, involved in the regulation of protein stability, subcellular location and activity. In this context, cytochrome c (Cc) is an excellent case study to analyze the structural and functional changes induced by PTMS as Cc is a small ...
Joaquin Tamargo‐Azpilicueta, Miguel Á. Casado‐Combreras, Rafael L. Giner‐Arroyo, Adrián Velázquez‐Campoy, Inmaculada Márquez, José L. Olloqui‐Sariego, Miguel A. De la Rosa, Irene Diaz‐Moreno   +7 more
wiley   +1 more source

Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis [PDF]

, 2019
A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control precisely where a reaction takes place. Here we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C‒H amidation ...
Arnold, Frances H., Cho, Inha, Jia, Zhi-Jun   +2 more
core