Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress [PDF]
, 2013 Lipid droplet (LD) formation is a hallmark of cellular stress. Cells attempt to combat noxious stimuli by switching their metabolism from oxidative phosphorylation to glycolysis, sparing resources in LDs for generating cellular reducing power and for ...
Choi, Augustine M. K. +3 more
core +3 more sources
Demonstration that spleen green hemeprotein is identical to granulocyte myeloperoxidase
Journal of Biological Chemistry, 1989 The biochemical, spectroscopic, enzymatic, and redox properties of spleen myeloperoxidase, a peroxidase formerly called "spleen green hemeprotein," and granulocyte myeloperoxidase were compared by electrophoresis, amino-terminal amino acid sequences, optical and EPR spectroscopy, steady-state enzyme kinetics, and oxidation-reduction potential.
M, Ikeda-Saito +7 more
openaire +2 more sources
Improved method for assembly of hemeprotein neuronal NO-synthase heterodimers [PDF]
Analytical Biochemistry, 2016 The assembly of mutated and wild type monomers into functional heterodimeric hemeproteins has provided important mechanistic insights. As in the case of NO synthase (NOS), the existing methods to make such heterodimeric NOSs are inefficient and labor intensive with typical yields of about 5%.
Yoshihiro, Morishima +3 more
openaire +2 more sources
Genetic Polymorphisms in CYP2 Gene Family in Bulgarian Individuals and their Clinical Implications
Acta Medica BulgaricaThe cytochrome P450 superfamily consists of hemeproteins involved in the detoxication of different xenobiotics, including drugs. The CYP2 gene family is responsible for the metabolism of 80% of the drugs in clinical use.
Yovinska S. +6 more
doaj +1 more source
Metabolic stability of superoxide adducts derived from newly developed cyclic nitrone spin traps [PDF]
, 2014 Reactive oxygen species are by-products of aerobic metabolism involved in the onset and evolution of various pathological conditions. Among them, the superoxide radical is of special interest as the origin of several damaging species such as H2O2 ...
Bézière, Nicolas +5 more
core +1 more source
Immobilization of proteins in silica gel: Biochemical and biophysical properties [PDF]
, 2015 The development of silica-based sol-gel techniques compatible with the retention of protein structure and function started more than 20 years ago, mainly for the design of biotechnological devices or biomedical applications.
Abbruzzetti, S +8 more
core +1 more source
Cofactor engineering for enhancing the flux of metabolic pathways. [PDF]
, 2014 The manufacture of a diverse array of chemicals is now possible with biologically engineered strains, an approach that is greatly facilitated by the emergence of synthetic biology.
Akhtar, MK, Jones, PR
core +3 more sources
Iron transfer and storage proteins [PDF]
, 2013 Željezo je vrlo bitan element za temeljne metaboličke procese. S obzirom na činjenicu da je neophodan za niz funkcija, organizmi ga moraju pohranjivati na način da bude netoksičan i brzo dostupan.
Kuhanec, Antonija
core +2 more sources
Will 1,2-dihydro-1,2-azaborine-based drugs resist metabolism by cytochrome P450 compound I? [PDF]
, 2016 1,2-dihydro-1,2-azaborine is a structural and electronic analogue of benzene which is able to occupy benzene-binding pockets in T4 lysozyme and has been proposed as suitable arene-mimicking group for biological and pharmaceutical applications.
Silva, Pedro J.
core +2 more sources
Finding Value in Wastewaters from the Cork Industry: Carbon Dots Synthesis and Fluorescence for Hemeprotein Detection [PDF]
, 2020 Marta R. Alexandre +3 more
openalex +1 more source