Results 81 to 90 of about 34,452 (261)
Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique
Nanomaterials, 2018 H2O2-sensitive nanofilms composed of DNA and hemin-appended poly(ethyleneimine) (H-PEI) were prepared by a layer-by-layer deposition of DNA and H-PEI through an electrostatic interaction.
Kentaro Yoshida +4 more
doaj +1 more source
Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer
Medicine Bulletin, EarlyView.ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei +7 more
wiley +1 more source
Hemin/G-quadruplex DNAzyme for Designing of Electrochemical Sensors
International Journal of Electrochemical Science, 2015 Guanine-rich nucleic acid sequence can fold into guanine quadruplex (G-quadruplex) that is found to complex tightly with hemin to form the hemin/G-quadruplex.
Guo-Cheng Han +2 more
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Structural Analysis and Inhibitor Modeling of Bacterioferritin From Brucella abortus
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Iron homeostasis in various pathogenic bacteria is regulated by bacterioferritins (Bfr) which function to store Fe3+ and release Fe2+ as needed for metabolic processes. The Bfr structure consists of 18 kDa subunits in which dimer pairs bind a heme molecule and are assembled into a highly symmetrical 24‐meric spherical structure with an ...
Lijun Liu +9 more
wiley +1 more source
Small, EarlyView.We report a magnetic particle anchored locked aptamer platform integrated with hyperbranched HCR and DNAzyme amplification for enzyme‐free, ultrasensitive detection of cardiac troponin I. The assay achieves a 0.25 ng/L detection limit within 25 minutes and enables cross‐species MI detection, with machine learning classification reaching 90% accuracy ...
Sayantan Tripathy +9 more
wiley +1 more source
RIP1 and RIP3 mediate hemin-induced cell death in HT22 hippocampal neuronal cells
Neuropsychiatric Disease and Treatment, 2018 Xingfen Su,1 Handong Wang,2 Yuanxiang Lin,1 Fuxiang Chen1 1Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, People’s Republic of China; 2Department of Neurosurgery, Jinling Hospital ...
Su X, Wang H, Lin Y, Chen F
doaj
Involvement of EGFR-AKT signaling in hemin-induced neurotoxicity
Experimental Biology and MedicineIntracerebral hemorrhage (ICH), as bleeding from ruptured vessels within the brain, is the second leading neuropathological problem following ischemic stroke.
Hui-Ju Huang +6 more
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Scientifica, 2016 In the brain, the heme oxygenase (HO) system has been reported to be very active and its modulation seems to play a crucial role in the pathophysiology of neurodegenerative disorders.
Merhan Ragy, Fatma Ali, Maggie M. Ramzy
doaj +1 more source
Advances in cholesterol and lipoproteins detection for healthcare: A review
VIEW, EarlyView.Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta +7 more
wiley +1 more source
Cell Proliferation, EarlyView.APA‐Guided Therapeutic miRNA Selection for Periodontitis. ABSTRACT Periodontitis is a chronic inflammatory disease driven by a dysregulated host immune response, in which macrophage‐mediated inflammation shifts from protective to pathological. While monocyte‐derived macrophages (MDMs) are known to adopt a destructive, M1‐like pro‐inflammatory phenotype,
Jing Zhang +6 more
wiley +1 more source