Results 111 to 120 of about 47,935 (263)

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss [PDF]

, 2017
L
Jeney, Viktória
core   +1 more source

Unveiling the Burden of Steatotic Liver Disease: Mortality Risks by Subtype and Fibrosis Stage in a Nationwide Cohort

Liver International, Volume 46, Issue 2, February 2026.
ABSTRACT Background and Aims We investigated the associations between SLD, fibrosis stage, and all‐cause and cause‐specific mortality, with a focus on SLD subtypes. Methods We analysed 486 156 UK Biobank participants. SLD cases were identified using fatty liver index ≥ 60. Causes of death were confirmed via death registries.
Qi Feng, Pinelopi Manousou, Chioma N. Izzi‐Engbeaya, Rohit Loomba, Mark Thursz, Mark Woodward   +5 more
wiley   +1 more source

Pathophysiological consequences and benefits of HFE mutations: 20 years of research

Haematologica, 2017
Mutations in the HFE (hemochromatosis) gene cause hereditary hemochromatosis, an iron overload disorder that is hallmarked by excessive accumulation of iron in parenchymal organs. The HFE mutation p.Cys282Tyr is pathologically most relevant and occurs in
Ina Hollerer, André Bachmann, Martina U. Muckenthaler   +2 more
doaj   +1 more source

HFE-Associated Hereditary Haemochromatosis

Canadian Journal of Gastroenterology, 2000
Hereditary hemochromatosis is a common inherited disorder of the iron metabolism. Screening studies indicate that it has a prevalence of one in 200 to 400, depending on the population studied, and a carrier rate of about one in seven to one in 10.
Emmeke J Eijkelkamp, Thomas R Yapp, Lawrie W Powell   +2 more
doaj   +1 more source

Hemochromatosis Treatment by Venipuncture Through History: Applying Venipuncture in the Treatment of Hemochromatosis

Southeastern European Medical Journal, 2018
Hemochromatosis is a hereditary disease caused by the mutation of genes responsible for regulating iron metabolism in the body. The mutation results in elevated iron absorption from the food that is deposited and stored in various organs and tissues. Due
Marija Čuljak
doaj   +1 more source

Case report: A rare case of hereditary hemochromatosis caused by a mutation in the HAMP gene in Fuyang, China

Frontiers in Medicine
Hemochromatosis, also known as siderosis, is a disease caused by excessive iron deposition in human organs and tissues, resulting from iron metabolism disorders.
Jinling Wang, Jing Xu, Ning Jiang, Hui Liu, Fengcheng Li, Beibei Wang, Jin Wang, Ziyu Chu, Lin Tan, Shasha Li   +9 more
doaj   +1 more source

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

Haematologica, 2011
Background Inadequate hepcidin production leads to iron overload in nearly all types of hemochromatosis. We explored the acute response of hepcidin to iron challenge in 25 patients with HFE-hemochromatosis, in two with TFR2-hemochromatosis and in 13 ...
Domenico Girelli, Paola Trombini, Fabiana Busti, Natascia Campostrini, Marco Sandri, Sara Pelucchi, Mark Westerman, Tomas Ganz, Elizabeta Nemeth, Alberto Piperno, Clara Camaschella   +10 more
doaj   +1 more source

Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. [PDF]

, 2002
BackgroundIron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger ...
Chew, Herbert George, Gibbs, Brett Jason, Hearthway, Megan Lesley, Motsko, Madelyne, Mullendore, Michael Eugene, Premo, Daniel Aaron, Sappington, Andrea, Turner, Lexa Rae, Walker, LeeAnn   +8 more
core   +1 more source

IgG subclass levels in referred hemochromatosis probands with HFE p.C282Y/p.C282Y.

PLoS ONE
BackgroundIgG subclass levels in hemochromatosis are incompletely characterized.MethodsWe characterized IgG subclass levels of referred hemochromatosis probands with HFE p.C282Y/p.C282Y (rs1800562) and human leukocyte antigen (HLA)-A and -B typing ...
James C Barton, J Clayborn Barton, Luigi F Bertoli, Ronald T Acton   +3 more
doaj   +1 more source

Disseminated cryptococcosis and hemochromatosis: clues to diagnosis

Autopsy and Case Reports, 2021
Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions.
Larry Nichols, Lindsey Rowley, Ashley Lall   +2 more
doaj