Results 121 to 130 of about 49,325 (314)
Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. [PDF]
, 2011 Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene (HFE) is associated with body lead
Aro, Antonio +8 more
core +1 more source
Molecular basis of HFE-hemochromatosis
Frontiers in Pharmacology, 2014 Iron-overload disorders owing to genetic misregulation of iron acquisition are referred to as hereditary hemochromatosis (HH). The most prevalent genetic iron overload disorder in Caucasians is caused by mutations in the HFE gene, an atypical MHC class I
M. Vujić
semanticscholar +1 more source
Association between CMR‐derived hepatic T1‐time, tricuspid regurgitation and survival
European Journal of Clinical Investigation, EarlyView.We investigated the association between tricuspid regurgitation (TR) severity and hepatic T1‐time in 1029 patients undergoing cardiac MRI and echocardiography. Hepatic T1‐time increased progressively with TR severity and remained independently associated after adjusting for NT‐proBNP and right ventricular function. Both TR and hepatic T1‐time predicted
Katharina Mascherbauer +19 more
wiley +1 more source
Hepatology Research, EarlyView.This study evaluated the effects of tirzepatide in patients with Type 2 diabetes mellitus and metabolic dysfunction‐associated steatotic liver disease. After 48 weeks of treatment, patients showed significant improvements in liver steatosis and injury, surrogate markers of liver fibrosis, glycemic control, and body weight. ABSTRACT Aim This study aimed
Taeang Arai +20 more
wiley +1 more source
Genetic Information and the Workplace - Full Report [PDF]
, 1998 Joint Agency ReportGeneticInfoWorkplace1998.pdf: 800 downloads, before Oct.
Department of Health and Human Services, U.S. +2 more
core +1 more source
Testing for HFE-related haemochromatosis [PDF]
, 2011 HFE-haemochromatosis is a genetic disorder resulting from mutations of the HFE gene. It primarily affects people of Northern European descent. Clinical manifestations result from the progressive deposition of iron into various organs including the liver.
Crawford, Darrell H. G. +2 more
core +1 more source
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.
Journal of Clinical Investigation, 2013 β-Thalassemia and HFE-related hemochromatosis are 2 of the most frequently inherited disorders worldwide. Both disorders are characterized by low levels of hepcidin (HAMP), the hormone that regulates iron absorption.
Shuling Guo +9 more
semanticscholar +1 more source
, 2017 Hereditary hemochromatosis is a disorder that causes the body to absorb too much iron from the diet. The three types of hemochromatosis are primary hemochromatosis, also called hereditary hemochromatosis; secondary hemochromatosis; and neonatal hemochromatosis.
openaire +1 more source
Gaucher disease, state of the art and perspectives
Journal of Internal Medicine, EarlyView.Abstract Knowledge about Gaucher disease (GD), considered a model for rare diseases, has considerably increased since its discovery. The pathophysiology of this lysosomal disorder is better known, and specific therapies that can control many aspects of the disease have been developed, particularly for the most common form, Type 1 GD.
Fabrice Camou, Marc G. Berger
wiley +1 more source
Pharmaceuticals, 2018 Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies„ ranging from hereditary hemochromatosis ...
Angeliki Katsarou, Kostas Pantopoulos
doaj +1 more source