Results 151 to 160 of about 49,325 (314)

Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin‐Independent Regulation of Fpn mRNA

open access: yesAmerican Journal of Hematology, Volume 100, Issue 8, Page 1323-1333, August 2025.
ABSTRACT The iron regulatory hormone hepcidin contributes to the pathogenesis of anemia of inflammation (AI) by inhibiting the iron exporter ferroportin in target cells, causing hypoferremia. Under acute inflammation, hepcidin induction requires hemojuvelin (Hjv), a bone morphogenetic protein co‐receptor, while Fpn mRNA is also suppressed in a hepcidin‐
Siqi Liu   +3 more
wiley   +1 more source

Persistent AST Elevation in a Patient With Ovarian Cancer: A Rare Diagnostic Challenge

open access: yesJournal of Clinical Laboratory Analysis, Volume 39, Issue 15, August 2025.
ABSTRACT Background Persistent elevation of aspartate aminotransferase (AST) is commonly indicative of liver injury or disease, but isolated AST elevation without concurrent alanine aminotransferase (ALT) increase is rare and difficult to diagnose. While AST is non‐specific and found in various tissues, its isolated elevation is due to less common ...
Lechuang Chen, Yu Zhang, Qing H. Meng
wiley   +1 more source

The common heritage of mankind : from the law of the sea to the human genome and cyberspace [PDF]

open access: yes, 2012
Since Arvid Pardo addressed the UN General Assembly in 1967 and proposed to declare the deep seabed and ocean floor the common heritage of mankind, the need has been felt to adapt the concept of common heritage to the human genome and the internet ...
Buttigieg, Jean
core  

Neonatal hemochromatosis.

open access: yesJournal of Clinical and Experimental Hepatology, 2020
Amy G. Feldman, P. Whitington
semanticscholar   +1 more source

The oral ferroportin inhibitor vamifeport prevents liver iron overload in a mouse model of hemochromatosis

open access: yesHemaSphere
Hemochromatosis is an inherited iron overload condition caused by mutations that reduce the levels of the iron‐regulatory hormone hepcidin or its binding to ferroportin.
Naja Nyffenegger   +7 more
doaj   +1 more source

The pathophysiology, presentation and classification of Type 1 diabetes

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue S6, Page 15-27, August 2025.
Abstract Type 1 diabetes is characterised by the autoimmune destruction of pancreatic β‐cells, leading to an absolute or near‐absolute insulin deficiency. Although traditionally associated with childhood onset, it can manifest at any age, and it is increasingly recognised that there is significant heterogeneity in its clinical presentation. This review
Kristie I. Aamodt, Alvin C. Powers
wiley   +1 more source

HLA and hemochromatosis disease association in São Miguel Island [PDF]

open access: yes, 2008
Mestrado em Biologia Molecular e CelularA hemocromatose hereditária uma doença autossómica recessiva do metabolismo do ferro, geralmente associada à mutação C282Y no gene HFE. Presume-se que a origem desta mutação tenha ocorrido por acaso no haplótipo
Gomes, Cidália Maria Teixeira
core   +1 more source

Genetic analysis of the correlation between GLP1 action and metabolic liver disease: Insights from Mendelian randomization analysis

open access: yesJournal of Diabetes Investigation, Volume 16, Issue 8, Page 1409-1419, August 2025.
Our study provides genetic analysis supporting the beneficial effects of GLP1 action on MASLD. These benefits may be attributed to mechanisms such as lowering blood glucose levels, reducing blood pressure, and improving HDL cholesterol levels. ABSTRACT Purpose Previous studies have shown that glucagon‐like peptide 1 (GLP1) receptor agonists may help ...
Zhiqiang Ma   +3 more
wiley   +1 more source

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