Results 171 to 180 of about 27,519 (222)
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Blood, 2008
To the editor: In their recent article, Waalen et al[1][1] address an important question connected to screening programs for hemochromatosis: How to find the individuals that would benefit from treatment.
Arne, Asberg +3 more
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To the editor: In their recent article, Waalen et al[1][1] address an important question connected to screening programs for hemochromatosis: How to find the individuals that would benefit from treatment.
Arne, Asberg +3 more
openaire +2 more sources
Clinica Chimica Acta, 2002
Hereditary hemochromatosis is the most common autosomal recessive disorder in populations of northern European descent.Many experts consider hemochromatosis to be an almost ideal disease for population screening because it essentially fulfills almost all the criteria for screening proposed by the WHO. However, others disagree and suggest that more data
McCullen, MA, Crawford, DHG, Hickman, PE
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Hereditary hemochromatosis is the most common autosomal recessive disorder in populations of northern European descent.Many experts consider hemochromatosis to be an almost ideal disease for population screening because it essentially fulfills almost all the criteria for screening proposed by the WHO. However, others disagree and suggest that more data
McCullen, MA, Crawford, DHG, Hickman, PE
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Current Treatment Options in Gastroenterology, 1999
The mainstay of treatment for hemochromatosis is therapeutic phlebotomy. The procedure is safe, effective, and relatively cheap. Deferoxamine (iron chelation) is necessary only in iron-loaded individuals who cannot undergo therapeutic phlebotomy. If therapy is initiated before complications develop, it is expected that no complications will ever ...
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The mainstay of treatment for hemochromatosis is therapeutic phlebotomy. The procedure is safe, effective, and relatively cheap. Deferoxamine (iron chelation) is necessary only in iron-loaded individuals who cannot undergo therapeutic phlebotomy. If therapy is initiated before complications develop, it is expected that no complications will ever ...
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Seminars in Hematology, 2002
Juvenile hemochromatosis or type 2 hemochromatosis is a rare inherited recessive disease, which leads to severe iron overload earlier in life than HFE-related hemochromatosis. Increased transferrin saturation and serum ferritin as well as parenchymal iron deposition and liver fibrosis may be observed in childhood.
C. Camaschella +2 more
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Juvenile hemochromatosis or type 2 hemochromatosis is a rare inherited recessive disease, which leads to severe iron overload earlier in life than HFE-related hemochromatosis. Increased transferrin saturation and serum ferritin as well as parenchymal iron deposition and liver fibrosis may be observed in childhood.
C. Camaschella +2 more
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Blood Cells, Molecules, and Diseases, 2002
We undertook a three-year screening program for mutations of the HFE gene among 41,000 subjects attending the Kaiser Permanente Health Appraisal Center in San Diego, California. Our results show that the C282Y and H63D mutations of the HFE gene associated with hemochromatosis have measurable and consistent effects on iron indicators and are associated ...
Jill, Waalen +4 more
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We undertook a three-year screening program for mutations of the HFE gene among 41,000 subjects attending the Kaiser Permanente Health Appraisal Center in San Diego, California. Our results show that the C282Y and H63D mutations of the HFE gene associated with hemochromatosis have measurable and consistent effects on iron indicators and are associated ...
Jill, Waalen +4 more
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2014
Hereditary hemochromatosis is due, in most cases, to a common genetic mutation in the HFE gene which leads to the C282Y substitution, which in turn can result in end organ damage from iron overload. The major manifestations in advanced disease are skin pigmentation, diabetes ('bronzed diabetes') and cirrhosis of the liver.
Wood, Marnie J. +2 more
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Hereditary hemochromatosis is due, in most cases, to a common genetic mutation in the HFE gene which leads to the C282Y substitution, which in turn can result in end organ damage from iron overload. The major manifestations in advanced disease are skin pigmentation, diabetes ('bronzed diabetes') and cirrhosis of the liver.
Wood, Marnie J. +2 more
openaire +4 more sources
Annals of Internal Medicine, 1998
The complications of iron overload in hemochromatosis can be avoided by early diagnosis and appropriate management.Therapeutic phlebotomy is used to remove excess iron and maintain low normal body ...
James C. Barton +7 more
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The complications of iron overload in hemochromatosis can be avoided by early diagnosis and appropriate management.Therapeutic phlebotomy is used to remove excess iron and maintain low normal body ...
James C. Barton +7 more
openaire +1 more source
Archives of Internal Medicine, 1986
Hemochromatosis is a hereditary disorder of the control of iron metabolism wherein the absorptive intestine accepts from the diet more iron than the body requires; because no excretory mechanism exists, the excess must be deposited in storage organs, ultimately to their detriment.
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Hemochromatosis is a hereditary disorder of the control of iron metabolism wherein the absorptive intestine accepts from the diet more iron than the body requires; because no excretory mechanism exists, the excess must be deposited in storage organs, ultimately to their detriment.
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Human Pathology, 1986
Neonatal hemochromatosis is a specific entity in the spectrum of pediatric liver disease. The clinical course is characterized by progressive deterioration, leading to death within a few days to weeks. The pathologic changes are hepatic fibrosis with massive iron accumulation in hepatocytes.
K S, Blisard, S A, Bartow
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Neonatal hemochromatosis is a specific entity in the spectrum of pediatric liver disease. The clinical course is characterized by progressive deterioration, leading to death within a few days to weeks. The pathologic changes are hepatic fibrosis with massive iron accumulation in hepatocytes.
K S, Blisard, S A, Bartow
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The Arthropathy of Hemochromatosis
Radiology, 1976Five cases of hemochromatosis arthropathy are presented and the distinctive radiological features of the disease are described. Although the condition is typically degenerative, showing subchondral cyst formation, sclerosis, and thinning of cartilage, its distribution is characteristic.
J H, Hirsch, F C, Killien, R H, Troupin
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