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Clinics in Liver Disease, 2004
Hemochromatosis is a common genetic disease with a wide range of clinical expression: from no symptoms to cirrhosis of the liver. The discovery of the gene has led to a genetic blood test useful in the diagnosis of hemochromatosis. Treatment by phlebotomy is simple and efficient and can prevent the development of cirrhosis, leading to a normal life ...
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Hemochromatosis is a common genetic disease with a wide range of clinical expression: from no symptoms to cirrhosis of the liver. The discovery of the gene has led to a genetic blood test useful in the diagnosis of hemochromatosis. Treatment by phlebotomy is simple and efficient and can prevent the development of cirrhosis, leading to a normal life ...
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Clinica Chimica Acta, 2002
Hereditary hemochromatosis is the most common autosomal recessive disorder in populations of northern European descent.Many experts consider hemochromatosis to be an almost ideal disease for population screening because it essentially fulfills almost all the criteria for screening proposed by the WHO. However, others disagree and suggest that more data
McCullen, MA, Crawford, DHG, Hickman, PE
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Hereditary hemochromatosis is the most common autosomal recessive disorder in populations of northern European descent.Many experts consider hemochromatosis to be an almost ideal disease for population screening because it essentially fulfills almost all the criteria for screening proposed by the WHO. However, others disagree and suggest that more data
McCullen, MA, Crawford, DHG, Hickman, PE
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Annals of Internal Medicine, 1998
The complications of iron overload in hemochromatosis can be avoided by early diagnosis and appropriate management.Therapeutic phlebotomy is used to remove excess iron and maintain low normal body ...
James C. Barton +7 more
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The complications of iron overload in hemochromatosis can be avoided by early diagnosis and appropriate management.Therapeutic phlebotomy is used to remove excess iron and maintain low normal body ...
James C. Barton +7 more
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Annals of Internal Medicine
Hemochromatosis is an inheritable condition that mainly affects White populations of European descent. Most patients remain asymptomatic, but others develop advanced organ damage that reduces quality of life and long-term survival. Arthropathy, diabetes mellitus, cirrhosis, hypogonadotropic hypogonadism, and cardiomyopathy are key clinical ...
William C, Palmer +1 more
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Hemochromatosis is an inheritable condition that mainly affects White populations of European descent. Most patients remain asymptomatic, but others develop advanced organ damage that reduces quality of life and long-term survival. Arthropathy, diabetes mellitus, cirrhosis, hypogonadotropic hypogonadism, and cardiomyopathy are key clinical ...
William C, Palmer +1 more
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Current Treatment Options in Gastroenterology, 1999
The mainstay of treatment for hemochromatosis is therapeutic phlebotomy. The procedure is safe, effective, and relatively cheap. Deferoxamine (iron chelation) is necessary only in iron-loaded individuals who cannot undergo therapeutic phlebotomy. If therapy is initiated before complications develop, it is expected that no complications will ever ...
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The mainstay of treatment for hemochromatosis is therapeutic phlebotomy. The procedure is safe, effective, and relatively cheap. Deferoxamine (iron chelation) is necessary only in iron-loaded individuals who cannot undergo therapeutic phlebotomy. If therapy is initiated before complications develop, it is expected that no complications will ever ...
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2014
Hereditary hemochromatosis is due, in most cases, to a common genetic mutation in the HFE gene which leads to the C282Y substitution, which in turn can result in end organ damage from iron overload. The major manifestations in advanced disease are skin pigmentation, diabetes ('bronzed diabetes') and cirrhosis of the liver.
Wood, Marnie J. +2 more
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Hereditary hemochromatosis is due, in most cases, to a common genetic mutation in the HFE gene which leads to the C282Y substitution, which in turn can result in end organ damage from iron overload. The major manifestations in advanced disease are skin pigmentation, diabetes ('bronzed diabetes') and cirrhosis of the liver.
Wood, Marnie J. +2 more
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Blood, 2008
To the editor: In their recent article, Waalen et al[1][1] address an important question connected to screening programs for hemochromatosis: How to find the individuals that would benefit from treatment.
Arne, Asberg +3 more
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To the editor: In their recent article, Waalen et al[1][1] address an important question connected to screening programs for hemochromatosis: How to find the individuals that would benefit from treatment.
Arne, Asberg +3 more
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American Heart Journal, 1953
Abstract A case of hemochromatosis with death due to heart failure has been presented. The literature has been reviewed with respect to the pathophysiology of congestive heart failure due to hemochromatosis. The possibility of fatty degeneration of the heart as a precursor of myocardial fibrosis was discussed.
E B, LEVIN, A, GOLUM
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Abstract A case of hemochromatosis with death due to heart failure has been presented. The literature has been reviewed with respect to the pathophysiology of congestive heart failure due to hemochromatosis. The possibility of fatty degeneration of the heart as a precursor of myocardial fibrosis was discussed.
E B, LEVIN, A, GOLUM
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The Arthropathy of Hemochromatosis
Radiology, 1976Five cases of hemochromatosis arthropathy are presented and the distinctive radiological features of the disease are described. Although the condition is typically degenerative, showing subchondral cyst formation, sclerosis, and thinning of cartilage, its distribution is characteristic.
J H, Hirsch, F C, Killien, R H, Troupin
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New England Journal of Medicine, 1993
In the United States the average daily intake of dietary iron ranges from 10 to 30 mg, but only about 1 mg is absorbed, to balance precisely the loss due to the sloughing of intact cells containing iron. Iron absorption can be increased if iron stores are depleted (usually through blood loss), and in genetically normal people absorption decreases with ...
Jane F. Desforges +2 more
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In the United States the average daily intake of dietary iron ranges from 10 to 30 mg, but only about 1 mg is absorbed, to balance precisely the loss due to the sloughing of intact cells containing iron. Iron absorption can be increased if iron stores are depleted (usually through blood loss), and in genetically normal people absorption decreases with ...
Jane F. Desforges +2 more
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