Results 11 to 20 of about 47,935 (263)
Neonatal Hemochromatosis [PDF]
Journal of Clinical and Experimental Hepatology, 2013 Neonatal hemochromatosis is a clinical condition in which severe liver disease in the newborn is accompanied by extrahepatic siderosis. Gestational alloimmune liver disease (GALD) has been established as the cause of fetal liver injury resulting in nearly all cases of NH.
Amy G, Feldman, Peter F, Whitington
openaire +3 more sources
Diabetes in HFE Hemochromatosis
Journal of Diabetes Research, 2017 Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are ...
James C. Barton, Ronald T. Acton
doaj +2 more sources
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis [PDF]
Nature Communications, 2014 Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional ...
Anderson, Denise +30 more
core +2 more sources
Hemochromatosis: Hereditary hemochromatosis and HFE gene
Vitamins and hormones, 2019 Hereditary Hemochromatosis (HH) is an autosomal recessive genetic disease, characterized by an excessively increased absorption of dietary iron. Excess iron can be accumulated because of the lack of an effective excretory mechanism leading to toxic effects. HH is one of the most common genetic disorders in individuals of European descent.
Katsarou, M.-S. +3 more
openaire +4 more sources
Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
Case Reports in Gastroenterology, 2015 Disturbances in iron metabolism can be genetic or acquired and accordingly manifest as primary or secondary iron overload state. Organ damage may result from iron overload and manifest clinically as cirrhosis, diabetes mellitus, arthritis, endocrine ...
Jasbir Makker +3 more
doaj +2 more sources
Hemochromatosis classification: update and recommendations by the BIOIRON Society
Blood, 2021 Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled intestinal iron absorption may lead to progressive iron overload (IO) responsible for disabling and life-threatening complications such as arthritis, diabetes, heart ...
D. Girelli +5 more
semanticscholar +1 more source
Revisiting hemochromatosis: genetic vs. phenotypic manifestations
Annals of Translational Medicine, 2021 Iron overload disorders represent an important class of human diseases. Of the primary iron overload conditions, by far the most common and best studied is HFE-related hemochromatosis, which results from homozygosity for a mutation leading to the C282Y ...
G. Anderson, E. Bardou-Jacquet
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source