Results 31 to 40 of about 49,325 (314)

Characterization of ferroptosis in murine models of hemochromatosis

Hepatology, 2017
Ferroptosis is a recently identified iron‐dependent form of nonapoptotic cell death implicated in brain, kidney, and heart pathology. However, the biological roles of iron and iron metabolism in ferroptosis remain poorly understood.
Hao Wang, P. An, Enjun Xie, Qian Wu, X. Fang, Hong Gao, Zhuzhen Zhang, Yuzhu Li, Xudong Wang, Jiaying Zhang, Guoliang Li, Lei Yang, Wei Liu, J. Min, Fudi Wang   +14 more
semanticscholar   +1 more source

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload [PDF]

, 2011
Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed.
Alan Waring, Bo Qiao, Elizabeta Nemeth, Emilio Ramos, Fujita, Gloria C. Preza, Gualdi, Kearney, Lyskov, Michael A. Peralta, Nemeth, Piotr Ruchala, Porter, Rogelio Pinon, Sham, Shantanu Sharma, Tomas Ganz   +16 more
core   +2 more sources

ACG Clinical Guideline: Hereditary Hemochromatosis

American Journal of Gastroenterology, 2019
Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the diagnosis, management, and treatment of HH.
Kris V. Kowdley, Kyle E. Brown, Joseph C. Ahn, V. Sundaram   +3 more
semanticscholar   +1 more source

IRON METABOLISM IN THALASSEMIA AND SICKLE CELL DISEASE

Mediterranean Journal of Hematology and Infectious Diseases, 2009
There are two main mechanisms by which iron overload develops in thalassemias: increased iron absorption due to ineffective erythropoiesis and blood transfusions.
Raffaella Mariani, Paola Trombini, Matteo Pozzi, Alberto Piperno   +3 more
doaj   +1 more source

Iron Metabolism in the Disorders of Heme Biosynthesis

Metabolites, 2022
Given its remarkable property to easily switch between different oxidative states, iron is essential in countless cellular functions which involve redox reactions. At the same time, uncontrolled interactions between iron and its surrounding milieu may be
Andrea Ricci, Giada Di Betto, Elisa Bergamini, Elena Buzzetti, Elena Corradini, Paolo Ventura   +5 more
doaj   +1 more source

Hepcidin and Host Defense against Infectious Diseases. [PDF]

, 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas, Mehrad, Borna, Michels, Kathryn, Nemeth, Elizabeta   +3 more
core   +1 more source

Non-HFE hemochromatosis

Revista Brasileira de Hematologia e Hemoterapia, 2012
Hereditary hemochromatosis (HH) is an autosomal recessive disorder classically related to HFE mutations. However, since 1996, it is known that HFE mutations explain about 80% of HH cases, with the remaining around 20% denominated non-HFE hemochromatosis.
Paulo Caleb Júnior de Lima Santos, Carla Luana Dinardo, Rodolfo Delfini Cançado, Isolmar Tadeu Schettert, José Eduardo Krieger, Alexandre Costa Pereira   +5 more
doaj   +1 more source

Discrepancy between Serum Ferritin and Liver Iron Concentration in a Patient with Hereditary Hemochromatosis – The Value of T2* MRI

Case Reports in Oncology, 2020
Primary hemochromatosis is an inherited disorder, and the homeostatic iron regulator (HFE) gene C282Y mutation is a common cause of hemochromatosis in Europe. We are reporting a case of a 56-year-old female known to have hemochromatosis with the HFE gene
Mustafa A. Al-Tikrity, Mohamed A. Yassin
doaj   +1 more source

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]

, 2018
Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António, Cancela, M. Leonor, Cohen-Solal, Martine, Hang Korng, Ea, Ostertag, Agnès, Pinto, I. Jorge, Porto, Graça, Simão, Márcio   +7 more
core   +4 more sources

Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE [PDF]

, 2000
The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.
Andrews, Nancy C., Bennett, Melanie J., Bjorkman, Pamela J., Enns, Caroline A., Sellers, Vera M., West, Anthony P., Jr.   +5 more
core   +1 more source