Results 61 to 70 of about 49,325 (314)
Liver transplantation for alcoholic cirrhosis: Long term follow-up and impact of disease recurrence [PDF]
Background. Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse.
Andrea M. DiMartini+71 more
core +1 more source
Management of cardiac hemochromatosis
Iron-overload syndromes may be hereditary or acquired. Patients may be asymptomatic early in the disease. Once heart failure develops, there is rapid deterioration.
W. Aronow
semanticscholar +1 more source
Hereditary hemochromatosis associated with autoimmune hemolytic anemia; A case report [PDF]
Hereditary hemochromatosis is a disease associated with highly iron overload. This disease caused by genetic mutations inherited through family. Autoimmune hemolytic anemia is also an important autoimmune disease in which red blood cells (RBC) are ...
Masih Falahatian+2 more
doaj
Serum Ferritin in Women With HFE p.C282Y Homozygosity: Positive Associations With Age, Live Births, Menopause, and Transferrin Saturation [PDF]
ABSTRACT Background We sought to determine associations of serum ferritin (SF) with live birth numbers and other iron‐related variables in women with HFE p.C282Y (rs1800562) homozygosity. Methods We studied non‐pregnant, non‐Hispanic white women in post‐screening evaluations to determine associations of SF with age, pregnancy and live birth numbers ...
Barton J, Barton J, Acton R.
europepmc +2 more sources
Semaglutide-Induced Hepatic Injury: A Rare Case of Drug Induced Liver Injury. [PDF]
ABSTRACT Semaglutide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is widely used for type 2 diabetes mellitus and has demonstrated hepatoprotective effects. However, this case highlights a rare instance of possible drug‐induced liver injury (DILI) temporally linked to its use. A middle‐aged male with well‐controlled diabetes, social alcohol use,
Kundu R, Shtoff L.
europepmc +2 more sources
Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression [PDF]
Hemojuvelin (HJV) is a glycosylphosphatidylinositol-linked protein and binds both bone morphogenic proteins (BMPs) and neogenin. Cellular HJV acts as a BMP co-receptor to enhance the transcription of hepcidin, a key iron regulatory hormone secreted ...
An-Sheng Zhang+44 more
core +4 more sources
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional ...
Beben Benyamin+68 more
semanticscholar +1 more source
Introduction Hereditary hemochromatosis is an inherited disorder of iron metabolism, characterized by excessive iron deposition in major organs of the body, leading to multi-organ dysfunction. It is a genetically heterogeneous disease caused by mutations
Wasanthi Wickramasinghe+3 more
doaj +1 more source
Identification of an iron–hepcidin complex [PDF]
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the 'iron hormone' which, by interacting with the iron transporter ferroportin,
Alex Drake+30 more
core +2 more sources
▪ Abstract In recent years, the number of proteins implicated in iron homeostasis has increased dramatically, and genetic causes have apparently been identified for the major disorders associated with tissue iron overload. These dramatic steps forward have transformed the way we look at iron-related disorders, particularly hemochromatosis.
openaire +4 more sources