Results 61 to 70 of about 37,295 (215)
HFE-Related Hemochromatosis in a Chinese Patient: The First Reported Case
Frontiers in Genetics, 2020 HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry.
Wei Zhang +28 more
doaj +1 more source
HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface [PDF]
, 2004 Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis.
Bjorkman, Pamela J. +1 more
core +1 more source
Hemochromatosis and Heart Involvement
Архивъ внутренней медициныHemochromatosis is a life-threatening condition if left untreated, that is caused by excess iron in the body. It can be primary (hereditary) hemochromatosis, resulting from genes mutations, and secondary (acquired) as a result of excessive intake of iron
E. V. Reznik +3 more
doaj +1 more source
Association of hemochromatosis with infectious diseases: expanding spectrum [PDF]
, 2007 SummaryWithholding iron from potential pathogens is a host defense strategy. There is evidence that iron overload per se compromises the ability of phagocytes to kill microorganisms.
Fisher, Melanie A. +2 more
core +1 more source
Frontiers in Cardiovascular Medicine, 2023 BackgroundIron overload cardiomyopathy (IOC) is a major co-morbidity of genetic hemochromatosis and secondary iron overload with limited therapeutic options.
Pavel Zhabyeyev +8 more
doaj +1 more source
Rare autosomal dominant hereditary hemochromatosis associated with SLC40A1 gene: ferroportin disease or type 4 hereditary hemochromatosis? [PDF]
, 2019 Ferroportin (FPN1), encoded by the SLC40A1 gene, is the unique cellular iron exporter identified in mammals. FPN1 transfers iron from the intestine and macrophages into the bloodstream. This function is negatively regulated by hepcidin.
Faustino, Paula +7 more
core
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source
The Development of Hemochromatosis after Treatment for Celiac Sprue
Canadian Journal of Gastroenterology, 1994 Celiac sprue is a chronic disease characterized by maldigestion and malabsorption. Whereas many diseases have been reported in association with celiac sprue, hemochromatosis has not.
Mang Ma, Edmond A Ryan, Vincent G Bain
doaj +1 more source
Idiopathic brain calcification in a patient with hereditary hemochromatosis
BMC Neurology, 2020 Background Detection of brain-MRI T2/T2* gradient echo images (T2*GRE)-hypointensity can be compatible with iron accumulation and leads to a differential diagnosis work-up including neurodegeneration with brain iron accumulation (NBIA) and Wilson Disease.
Stefania Scarlini +10 more
doaj +1 more source