Results 31 to 40 of about 195,910 (216)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Hemodynamic and Metabolic Responses to Ketamine and Etomidate Sedations During Endotracheal Intubation in Criticallyill Patients

Türk Yoğun Bakim Derneği Dergisi, 2011
Objective: The aim of this study was to compare the effects of etomidate and ketamine on hemodynamic and metabolic responses to intubation in ICU patients.
Özlem Çınar, Arash Pirat, Pınar Zeyneloğlu, Aynur Camkıran, Nilüfer Bayraktar, Coşkun Araz, Gülnaz Arslan   +6 more
doaj   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Classification of Tactile and Motor Velocity-Evoked Hemodynamic Response in Primary Somatosensory and Motor Cortices as Measured by Functional Near-Infrared Spectroscopy

Applied Sciences, 2020
Functional near-infrared spectroscopy (fNIRS) is an emerging technique in studying cerebral hemodynamics; however, consensus on the analysis methods and the clinical applications has yet to be established.
Mohsen Hozan, Jacob Greenwood, Michaela Sullivan, Steven Barlow   +3 more
doaj   +1 more source

Comparison of two doses of intravenous esmolol in attenuation of hemodynamic response to extubation in laparoscopic surgeries

The Indian Anaesthetists' Forum, 2022
Aims and Objectives: The purpose of this study was the comparison of hemodynamic variables such as heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure during the extubation period following administration of two ...
S A Kshama, Laxmi Shenoy, Shweta Sinha
doaj   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

A comparative evaluation of efficacy of lignocaine and dexmedetomidine to attenuate hemodynamic and airway responses to endotracheal extubation in elective coronary artery bypass graft surgery: a prospective randomized double-blind clinical study [PDF]

Anesthesia and Pain Medicine
Background Extubation is more stressful than intubation because it leads to unpredictable hemodynamic and airway responses. Therefore, in this study, we compared the efficacy of dexmedetomidine and lignocaine in attenuating hemodynamic and airway ...
Mithilesh Kumar, Arvind Kumar, Mumtaz Hussain, Alok Kumar Bharti, Abhinav Kumar   +4 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

A comparative evaluation of dexmedetomidine and fentanyl to attenuate hemodynamic response to laryngoscopy and intubation

Asian Journal of Medical Sciences, 2018
Background: Laryngoscopy and intubation are associated with a sympathetically mediated circulatory response due to irritation of respiratory tract which is associated with increase in pulse rate and blood pressure that may be dangerous.
Erum Ozair
doaj   +1 more source