Results 1 to 10 of about 571,254 (145)
Brazilian Journal of Medical and Biological Research, 2007 Vertebrate hemoglobin, contained in erythrocytes, is a globular protein with a quaternary structure composed of 4 globin chains (2 alpha and 2 beta) and a prosthetic group named heme bound to each one. Having myoglobin as an ancestor, hemoglobin acquired the capacity to respond to chemical stimuli that modulate its function according to tissue ...
Souza, P. C. de +1 more
openaire +7 more sources
Solubilization of hemoglobin S by other hemoglobins. [PDF]
Proceedings of the National Academy of Sciences, 1980 The polymerization of mixtures of Hb S with hemoglobins A, A2, and F has been investigated by analysis of the proportions of S and non-S hemoglobin both in the supernate and in the pellet after centrifugation. In all cases the non-S hemoglobin was incorporated into the polymer even in the absence of hybrids in the order A > A2 > F. The solubility
Suzanna Kwong +3 more
openaire +3 more sources
Acceleration of hemoglobin C crystallization by hemoglobin S [PDF]
Blood, 1989 We previously reported that circulating hemoglobin (Hb) CC erythrocytes contain oxygenated HbC crystals with little or no HbF and that HbF inhibits in vitro crystallization of HbC. We now report that HbS accelerates in vitro crystallization of HbC. Crystals were formed in 1.8 mol/L potassium phosphate buffer, pH 7.4, at 30 degrees C and were counted in
Rhoda Elison Hirsch +2 more
openaire +3 more sources
European Spine Journal, 2004 Orthopaedic patients frequently require blood transfusions to treat peri-operative anemia. Research in the area of hemoglobin substitutes has been of great interest since it holds the promise of reducing the reliance on allogeneic blood transfusions. The three categories of hemoglobin substitutes are (1) cell-free, extracellular hemoglobin preparations
Jonathan P. Garino +2 more
openaire +3 more sources
Hemoglobin I: An Inherited Hemoglobin Anomaly [PDF]
Blood, 1955 Abstract A hitherto undescribed hemoglobin anomaly has been detected in a North Carolina Negro family. This new hemoglobin, designated type I, which has been electrophoretically characterized, was found in combination with normal adult A hemoglobin in 6 of 17 members of one family.
D. L. Rucknagel +2 more
openaire +3 more sources
Effect of liganded hemoglobin S and hemoglobin A on the aggregation of deoxy-hemoglobin S.
Journal of Biological Chemistry, 1982 The effect of the carbonmonoxy forms of Hb S and Hb A on the solubility and kinetics of the aggregation of deoxy-Hb S in concentrated phosphate buffer was studied. The delay time was prolonged exponentially when the ratios of CO-Hb S and CO-Hb A to deoxy-Hb S were increased.
K Adachi, T Asakura
openaire +3 more sources
Hemoglobin E disease and glycosylated hemoglobin
Indian Journal of Endocrinology and Metabolism, 2015 Glycosylated hemoglobin (HbA1C) is a routinely measured parameter to monitor long-term glycemic control in people with diabetes mellitus. The presence of hemoglobin (Hb) variants can affect the accuracy of HbA1C methods. Hb E variant is the most common Hb variant in South-east Asia and North-east India.
Mohammad Shafi Kuchay +2 more
openaire +4 more sources
Aggregation of hemoglobin S and hemoglobin CHarlem with nonsickle hemoglobin in concentrated phosphate buffer [PDF]
Blood, 1980 Abstract The effect of HbA and HbF on both the aggregation and deaggregation of deoxy HbS and deoxy HbCHarlem in concentrated phosphate buffers was studied by a turbidimetric method. Although pure deoxy HbA is fully soluble in 2.4 M potassium phosphate buffer, the same concentration of deoxy HbAS was insoluble in the same buffer.
Kazuhiko Adachi +2 more
openaire +4 more sources
Low proportions of glycosylated hemoglobin associated with hemoglobin S and hemoglobin C.
Clinical Chemistry, 1979 Abstract Using a cation-exchange chromatographic method, we found normal or subnormal values for glycosylated hemoglobin in a few diabetic patients with persistent hyperglycemia. Subsequent investigations revealed that these unexpected results had originated from black patients with diabetes.
openaire +3 more sources
Is Hemoglobin Antigenic? [PDF]
Journal of Infectious Diseases, 1919 Thus in work reported by Leblanc,1 a precipitin for beef hemoglobin was obtained by immunizing a dog with a preparation obtained by saturating laked, washed, red cells with ammonium sulphate after removal of globulins and stromata. This preparation was by no means pure since no attempt was made to free the hemoglobin from possible contamination by ...
Schmidt, C. L. A., Bennett, C. B.
openaire +2 more sources