Results 171 to 180 of about 655,757 (265)

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Transfusion rates in oral and maxillofacial surgery and their influencing factors in the context of patient blood management. [PDF]

Clin Oral Investig
Mönnikes N, Fenske J, Steffen C, Wu V, Treskatsch S, Heiland M, Rendenbach C, Pruß A.   +7 more
europepmc   +1 more source

Dynamic Regulation of Supramolecular Chirality in an Amphiphilic Dimeric Macrocycle Through Azobenzene‐Based Photoisomerization

Advanced Science, EarlyView.
A stimuli‐responsive supramolecular system has been rationally designed enabling hierarchical control over supramolecular handedness. This hybrid architecture retains orthogonal host‐guest properties and displays unique amphiphilicity‐directed chiral self‐assembly.
Minzan Zuo, Yi Shi, Xueqi Tian, Tao Zhang, Jianmin Jiao, Yuhong Shen, Yutong Xie, Jianwen Wei, Xiao‐Yu Hu   +8 more
wiley   +1 more source

Mitapivat for sickle cell disease: the time is ripe for a new therapy. [PDF]

Ann Transl Med
Cheng AN, Al-Samkari H.
europepmc   +1 more source

Silicon‐Embedded Multifunctional Heterogeneous Integration for Miniaturized Photoplethysmography Detection Devices

Advanced Science, EarlyView.
ABSTRACT The multifunctional integration of chips with high flexibility and scalable manufacturing is crucial for enhancing chip performance, reducing chip size, and simplifying chip design. However, balancing volume, cost, flexibility, and functionality using traditional heterogeneous integration methods is challenging.
Lang Chen, Shizun Hu, Zhou Yang, Shitao Shen, Pan Zhang, Han Xu, Chi Zhang, Wei Wang   +7 more
wiley   +1 more source

Suzetrigine for Vaso-Occlusive Pain in Sickle Cell Disease: A Three-Patient Case Series. [PDF]

Orthop Rev (Pavia)
Joudeh S, Moore D, Hasoon J, Robinson CL, Idowu M, Oso T.   +5 more
europepmc   +1 more source

Sticky Yet Slippery: Molecular Ordering Reconciles Bubble‐Surface Affinity With Ultralow Friction at the Nanoscale

Advanced Science, EarlyView.
By engineering the molecular order and thickness of PDMS layers, we reconcile the stickiness and slipperiness during bubble transport. AFM measurements and MD simulations further reveal how these nanoscale architectures tune hydrophobic interaction FHB and friction force f.
Shishuang Zhang, Jiajun Li, Huadong Tian, Zhoujie Wang, Chenyu Qiao, Jingyi Wang, Lei Xie, Hongbo Zeng   +7 more
wiley   +1 more source

Uncoupling Erythropoiesis from Cardiorenal Effects: SGLT2 Inhibition in Non-Diabetic Heart Failure. [PDF]

Medicina (Kaunas)
Măgureanu DC, Bocsan IC, Pop RM, Neag MA, Cozma A, Buzoianu AD.   +5 more
europepmc   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

The Effect of Iclepertin on Hematological Parameters: An Overview of Nonclinical Studies and Clinical Trials in Healthy Volunteers and Patients with Cognitive Impairment Associated with Schizophrenia. [PDF]

J Clin Pharmacol
Nagy P, Fowler JC, Rosenbrock H, Tang W, Fu E, Fraser A, Dursema H, Schlichtiger J, Desch M, Gruenenfelder F.   +9 more
europepmc   +1 more source