Results 81 to 90 of about 23,660,822 (374)

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Evidence for multiple structural genes for the γ chain of human fetal hemoglobin [PDF]

, 1968
A sequence with a specific residue at each position was proposed for the γ chain of human fetal hemoglobin by Schroeder et al. (1) after a study in which hemoglobin from a number of individual infants was used.
Dozy, Andrée M., Huisman, T. H. J., Kleihauer, Enno F., Robberson, Barbara, Schroeder, W. A., Shelton, J. Roger, Shelton, Joan Balog   +6 more
core  

Podoconiosis and soil-transmitted helminths (STHs): double burden of neglected tropical diseases in Wolaita zone, rural southern Ethiopia [PDF]

, 2013
Background Both podoconiosis and soil-transmitted helminth (STH) infections occur among barefoot people in areas of extreme poverty; however, their co-morbidity has not previously been investigated.
A Mengistu, AA Paivaa, Asaye Birhanu, Aster Tsegaye, B Nkrumah, B Yakob, Bereket Alemayehu, Beyene Petros, Bineyam Taye, D Elias, DD Ramdath, DL Smillie WG & Augustine, E McConnel, EW Price, EW Price, F Tekola, F Tekola, G Davey, G Hailemariam, Gail Davey, JG Banwell, JG Banwell, JM Shield, K Desta, K Desta, Kassu Desta, LJ Robertson, M Azami, MS Chan, PJ Hotez, PJ Hotez, PJ Hotez, Rachel L. Pullan, RJ Stoltzfus, S Addisu, S Assefa, S Tedla, Sisay Addisu, T Dejenie, V Chongsuvivatwong, Y Belyhun   +40 more
core   +2 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

SmartHeLP: Smartphone-based Hemoglobin Level Prediction Using an Artificial Neural Network [PDF]

, 2018
Blood hemoglobin level (Hgb) measurement has a vital role in the diagnosis, evaluation, and management of numerous diseases. We describe the use of smartphone video imaging and an artificial neural network (ANN) system to estimate Hgb levels non ...
Adib, Riddhiman, Ahamed, Sheikh Iqbal, Begum, Azima, Haque, Md. Munirul, Hasan, Md Kamrul, Kim, Young, Love, Rechard M., Tumpa, Jannatul F.   +7 more
core   +1 more source

Vitamin A Supplementation and Other Predictors of Anemia Among Children from Dar Es Salaam, Tanzania. [PDF]

, 2000
The associations of hemoglobin, hematocrit, and packed cell volume with socioeconomic factors, malaria, human immunodeficiency virus (HIV) infection, and nutritional status were examined among 687 children admitted to hospital with pneumonia ...
Fawzi, W W, Mbise, R, Ndossi, G, Spiegelman, D, Villamor, E   +4 more
core   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

Coffee Consumption Is Associated With Later Age‐at‐Onset of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Observation studies suggest that coffee consumption may lower the risk and delay the age‐at‐onset (AAO) of Parkinson's disease (PD). The aim of this study was to explore the causal relationship and genetic association between coffee consumption and the AAO, risk, and progression of PD. Using Mendelian randomization, we identified a significant
Dariia Kuzovenkova, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +3 more
wiley   +1 more source

Cross-sectional and longitudinal association between hemoglobin concentration and hypertension

Medicine, 2016
We investigated the cross-sectional and longitudinal associations between hemoglobin concentration and hypertension in a Korean population. Between 2006 and 2013, we examined 4899 participants with mean age of 56.6 years (range 35–88 years) from a rural ...
Na Hyun Kim, Ju-Mi Lee, H. Kim, J. Lee, Hyungseon Yeom, J. H. Lee, I. Suh   +6 more
semanticscholar   +1 more source