Results 221 to 230 of about 732,100 (298)

Alpha-thalassemia in a pool of individuals of Eti-Turk origin with hemoglobin S (Hb S)

open access: yesThe Turkish Journal of Pediatrics, 1987
H Jama, A Gürgey, C Altay
doaj  

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

open access: yesAdvanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang   +14 more
wiley   +1 more source

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

open access: yesAdvanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song   +11 more
wiley   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

open access: yesAdvanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu   +18 more
wiley   +1 more source

Reconfigurable, Temperature Resilient Phase‐Change Metasurfaces Fabricated via High Throughput Nanoimprinting Lithography

open access: yesAdvanced Science, EarlyView.
ABSTRACT The combination of metasurfaces with chalcogenide phase‐change materials is a highly promising route toward the development of multifunctional and reconfigurable nanophotonic devices. However, their transition into real‐world devices is hindered by several technological challenges. This includes, amongst others, the lack of large area photonic
Carlota de Ruiz de Galarreta   +8 more
wiley   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu   +6 more
wiley   +1 more source

Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria parasitemia. [PDF]

open access: yesPLoS One, 2013
Rougeron V   +8 more
europepmc   +1 more source

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