Results 1 to 10 of about 23,191 (234)

EVOLUTION OF HEMOGLOBINOPATHY PREVENTION IN AFRICA [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2009
Hemoglobinopathies are a group of inherited hemoglobin disorders. Initially described in the subtropical regions, they are now spread all around the world because of migration.
Slaheddine Fattoum
doaj   +2 more sources

Hemoglobinopathies in Iran: An Updated Review

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Hemoglobinopathies are the most common single gene disorders (monogenic disorders) in the world population.  Due to specific position of Iran and the presence of multi-ethnic groups in the country, there are many varieties in the molecular genetics and ...
Abolfazl Nasiri, Zohreh Rahimi, Asad Vaisi-Raygani   +2 more
doaj   +2 more sources

Newborn Screening for Sickle Cell Disease and Other Hemoglobinopathies: A Short Review on Classical Laboratory Methods—Isoelectric Focusing, HPLC, and Capillary Electrophoresis

International Journal of Neonatal Screening, 2018
Sickle cell disease (SCD) and other hemoglobinopathies are a major health concern with a high burden of disease worldwide. Since the implementation of newborn screening (NBS) for SCD and other hemoglobinopathies in several regions of the world, technical
Claudia Frömmel
doaj   +2 more sources

COVID-19 infection and beta thalassemia; a single center experience in Iran [PDF]

Journal of Preventive Epidemiology, 2021
Introduction: COVID-19 infection is a contagious acute respiratory syndrome, leading to a high mortality rate; it is also a systemic disease, and all people are at risk of being infected, including hemoglobinopathies patients.
Roya Salehi Kahyesh, Arash Alghasi, Bijan Keikhaei Dehdezi, Adeleh Khazami, Marzeieh Abbasi Nasab   +4 more
doaj   +1 more source

Epidemiological surveillance of SARSCov2 in β-Thalassemia Patients in the last two years: reinfection rate, insights and future challenges

Mediterranean Journal of Hematology and Infectious Diseases, 2023
Background: Although the association between comorbidities and the severity of COVID-19 infection has been extensively discussed, data on COVID-19 and hemoglobinopathies are still limited.
Lorenza Torti, Francesco Sorrentino, Laura Maffei, Paolo De Fabritiis, Elisabetta Abruzzese   +4 more
doaj   +1 more source

Endocrinopathies in Hemoglobinopathies: What Is the Role of Iron?

International Journal of Molecular Sciences, 2023
Hemoglobinopathies, including β-thalassemia and sickle cell disease (SCD), are common genetic blood disorders. Endocrine disorders are frequent manifestations of organ damage observed mainly in patients with β-thalassemia and rarely in SCD. Iron overload,
Paschalis Evangelidis, T. Venou, Barmpageorgopoulou Fani, E. Vlachaki, E. Gavriilaki   +4 more
semanticscholar   +1 more source

Epigenetic Regulation of β-Globin Genes and the Potential to Treat Hemoglobinopathies through Epigenome Editing

Genes, 2023
Beta-like globin gene expression is developmentally regulated during life by transcription factors, chromatin looping and epigenome modifications of the β-globin locus.
L. Fontana, Zoe Alahouzou, A. Miccio, P. Antoniou   +3 more
semanticscholar   +1 more source

The hemoglobinopathies, molecular disease mechanisms and diagnostics

International Journal of Laboratory Hematology, 2022
Hemoglobinopathies are the most common monogenic disorders in the world with an ever increasing global disease burden each year. As most hemoglobinopathies show recessive inheritance carriers are usually clinically silent.
C. Harteveld, Ahlem Achour, Sandra G. J. Arkesteijn, J. T. ter Huurne, M. Verschuren, Sharda Bhagwandien-Bisoen, Rianne Schaap, L. Vijfhuizen, Hakima El Idrissi, T. Koopmann   +9 more
semanticscholar   +1 more source

Incidence of cancer and related deaths in hemoglobinopathies: A follow‐up of 4631 patients between 1970 and 2021

Cancer, 2022
The correlation between thalassemia and malignancies other than hepatocellular carcinoma (HCC) and the possible relationship between other hemoglobinopathies and tumor risk have been poorly evaluated.
R. Origa, Barbara Gianesin, F. Longo, R. Di Maggio, E. Cassinerio, M. Gamberini, V. Pinto, A. Quarta, M. Casale, G. La Nasa, G. Caocci, A. Piroddi, A. Piolatto, Alessandra Danuta Di Mauro, C. Romano, Antonia Gigante, S. Barella, A. Maggio, G. Graziadei, S. Perrotta, G. Forni   +20 more
semanticscholar   +1 more source

Hb^Adrian (α1:c.251del, p.Leu84Argfs*19)—A Novel Pathogenic Variant in the α1-Globin Gene Associated with Microcytosis from the North of Iran

Thalassemia Reports, 2023
Background: Alpha thalassemia is one of the most common human genetic abnormalities. More than 400 different variations of the α-globin protein have been introduced, most of which are not associated with noticeable clinical manifestations.
Hossein Jalali, Hossein Karami, Mahan Mahdavi, Mohammad Reza Mahdavi   +3 more
doaj   +1 more source