Results 11 to 20 of about 25,718 (237)
The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. [PDF]
, 2015 Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene.
Baldwin, Kismet M +12 more
core +8 more sources
Student's knowledge and attitude toward hemoglobinopathies premarital screening
Hail Journal of Health Sciences, 2022 Background: Hemoglobinopathies are common in Saudi Arabia. The highest prevalence of thalassemia and sickle cell disease (SCD) was observed in the Eastern and Jazan regions.
Wedad Alhazmi, Sarah Salih, Anas E Ahmed
doaj +1 more source
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]
, 2017 Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R. +11 more
core +5 more sources
Coexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum! [PDF]
, 2017 Sickle cell disease and Sarcoidosis are conditions that are more common in the African American population. In this report we share an unfortunate patient who had hepatic sarcoidosis but could not receive steroids since that precipitated acute liver ...
Gollahalli, Nagesh S., Nutan, FNU
core +3 more sources
Thalassemia Reports, 2014 The aims of this study are: i) to enquire whether informing healthy hemoglobinopathy carriers about their condition is a welcome initiative in The Netherlands; ii) to study whether using information letters and thorough explanation is associated with ...
Piero C. Giordano +4 more
doaj +1 more source
Biomedical Research, A Tool to Address the Health Issues that Affect African Populations. [PDF]
, 2013 Traditionally, biomedical research endeavors in low to middle resources countries have focused on communicable diseases. However, data collected over the past 20 years by the World Health Organization (WHO) show a significant increase in the number of ...
Peprah, Emmanuel, Wonkam, Ambroise
core +3 more sources
Thalassemia Reports, 2014 Hemoglobinopathies (HBP) are the most common genetic disorder in Oman and are in need of prevention programs due to the high incidence of β-thalassemia major and sickle cell disease. Prenatal diagnosis (PD) and selective pregnancy termination is shown to
Suha Mustafa Hassan +3 more
doaj +1 more source
International Journal of Hematology-Oncology and Stem Cell Research, 2018 Background: Cancer affects the physical, psychological, and social aspects of the patients’ life. Cancer-related fatigue (CRF) is the most common and severe condition among cancer patients. Ginseng has long been used as an efficient treatment for CRF and
Khatereh Pourmohamadi +2 more
doaj +1 more source
Clinical Case Reports, 2022 SQSTM1 gene encodes a protein called p62 that acts as an autophagy receptor in the degradation of protein molecules. A homozygous deletion variant that changes the frame shift in the SQSTM1 gene named c.790 Del A .T was detected in case childhood onset ...
Hossein Jalali +3 more
doaj +1 more source
Positive predictive value of diagnosis coding for hemolytic anemias in the Danish National Patient Register [PDF]
, 2016 PURPOSE: The nationwide public health registers in Denmark provide a unique opportunity for evaluation of disease-associated morbidity if the positive predictive values (PPVs) of the primary diagnosis are known.
Frederiksen, Henrik +3 more
core +2 more sources