Results 11 to 20 of about 20,435 (244)

GENE THERAPY IN THALASSEMIA AND HEMOGLOBINOPATHIES

Mediterranean Journal of Hematology and Infectious Diseases, 2009
Sickle cell disease (SCD) and ß-thalassemia represent the most common hemoglobinopathies caused, respectively, by the alteration of structural features or deficient production of the ß-chain of the Hb molecule.
Laura Breda, Roberto Gambari, Stefano Rivella   +2 more
doaj   +2 more sources

Hemoglobin Lepore-Boston-Washington: A Rare Cause of Unmeasurable HbA1c and Diagnostic Challenge in Diabetes. [PDF]

J Clin Lab Anal
Journal of Clinical Laboratory Analysis, EarlyView.
Russo F, Trombetti S, Storino MR, Sessa R, De Felice C, Schiavone G, Grosso M.   +6 more
europepmc   +2 more sources

Impact of hemoglobinopathies upon behaviors of adolescents [PDF]

, 2022
Background: Hemoglobinopathies are the most common life threatening, monogenic disorders in the world. The most common causes of hemoglobinopathies are sickle cell disease and thalassemia. Objectives: The purpose of this study is to investigate Impact of
Hasan, Abdul Mahdi A., Badr, Shahznan Hassan   +1 more
core   +1 more source

Nephrological Complications in Hemoglobinopathies: SITE Good Practice [PDF]

, 2023
Background. Hemoglobinopathies, among which thalassemic syndromes (transfusion-dependent and non-transfusion dependent thalassemias) and sickle cell disease (SCD), are the most widespread monogenic diseases worldwide.
Antonia Gigante, Giovan Battista Ruffo, Giacomo Garibotto, Lucia De Franceschi, Monia Marchetti, Aurelio Maggio, Vincenzo Voi, Gian Luca Forni, Rodolfo Russo, Valeria Orecchia, Tommaso Casini, Letizia Lombardini, Raffaella Origa   +12 more
core   +2 more sources

Mutation Spectrum of Hemoglobinopathies in Tunisia. [PDF]

Hum Mutat
International audienceIntroduction: Hemoglobinopathies are the most prevalent recessive disorders worldwide, characterized by wide molecular and clinical heterogeneity.
Moumni I, Khalfaoui K, Chebbi M, Chaouch L, Ouragini H, Chaouechi D, Mellouli F, Ouederni M, Benkhaled M, Abbes S, Menif S.   +10 more
europepmc   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer. [PDF]

Mol Oncol
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Yu M, Das P, Zhang X, Cheng X.
europepmc   +2 more sources

Providing appropriate genetic information to healthy multi-ethnic carriers of hemoglobinopathy in The Netherlands

Thalassemia Reports, 2014
The aims of this study are: i) to enquire whether informing healthy hemoglobinopathy carriers about their condition is a welcome initiative in The Netherlands; ii) to study whether using information letters and thorough explanation is associated with ...
Piero C. Giordano, Natasha B.D. Binda, Antonio Amato, Egbert Bakker, Cornelis L Harteveld   +4 more
doaj   +1 more source

Quality of life among adolescents with hemoglobinopathies [PDF]

, 2022
Background: Hemoglobinopathies constitute the commonest recessive monogenic disorders worldwide, and the treatment of affected individuals presents a substantial global disease burden.
Hasan, Abdul Mahdi A., Badr, Shahznan Hassan   +1 more
core   +2 more sources

Primary prevention of hemoglobinopathies by prenatal diagnosis and selective pregnancy termination in a Muslim country: Oman

Thalassemia Reports, 2014
Hemoglobinopathies (HBP) are the most common genetic disorder in Oman and are in need of prevention programs due to the high incidence of β-thalassemia major and sickle cell disease. Prenatal diagnosis (PD) and selective pregnancy termination is shown to
Suha Mustafa Hassan, Egbert Bakker, Cornelis L. Harteveld, Piero C. Giordano   +3 more
doaj   +1 more source

Investigating the Effects of Oral Ginseng on the Cancer-Related Fatigue and Quality of Life in Patients with Non-Metastatic Cancer

International Journal of Hematology-Oncology and Stem Cell Research, 2018
Background: Cancer affects the physical, psychological, and social aspects of the patients’ life. Cancer-related fatigue (CRF) is the most common and severe condition among cancer patients. Ginseng has long been used as an efficient treatment for CRF and
Khatereh Pourmohamadi, Ahmad Ahmadzadeh, Mahmood Latifi   +2 more
doaj   +1 more source