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Hemoglobinopathies

2022
Hemoglobinopathies are a group of inherited blood disorders characterized by compromised hemoglobin function. Hemoglobin is a 64kDa protein, consisting of four globin polypeptides each containing one heme molecule; blood acquires its red color from this heme molecule.
Eugene Khandros, Janet L. Kwiatkowski
  +4 more sources

Hemoglobinopathies

Hematology, 2003
AbstractThe outlook for patients with sickle cell disease has improved steadily during the last two decades. In spite of these improvements, curative therapies are currently available only to a small minority of patients. The main theme of this chapter is to describe new therapeutic options that are at different stages of development that might result ...
George F, Atweh   +7 more
openaire   +2 more sources

Sickle hemoglobinopathies

Current Opinion in Pediatrics, 1993
Neonatal screening for hemoglobinopathies, coupled with comprehensive medical care that includes parental education, prophylactic penicillin, and immunizations, has markedly reduced mortality from sickle hemoglobinopathies during infancy and early childhood.
openaire   +2 more sources

Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: the HGB-205 trial

Nature Medicine, 2022
Elisa Magrin   +2 more
exaly  

Hemoglobinopathies.

Major problems in internal medicine, 1977
The determination of the structure of hemoglobin is one of the milestones of molecular biology. This information has provided an intimate understanding of the way in which the molecule functions physiologically; Study of hemoglobin has proved relevant to a number of biomedical disciplines.
H F, Bunn, B G, Forget, H M, Ranney
openaire   +1 more source

The hemoglobinopathies, molecular disease mechanisms and diagnostics

International Journal of Laboratory Hematology, 2022
Cornelis L Harteveld
exaly  

HEMOGLOBINOPATHY

Hemoglobinopathies are a group of severe hereditary blood diseases caused by a violation of the structure of hemoglobin or a decrease in the synthesis of one or more globin chains. The clinical picture is extremely varied. Common symptoms are hemolytic anemia, enlarged spleen, and bone damage.
openaire   +1 more source

Hemoglobinopathies

2006
Geoffrey G. Emerson   +4 more
openaire   +2 more sources

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