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2022
Hemoglobinopathies are a group of inherited blood disorders characterized by compromised hemoglobin function. Hemoglobin is a 64kDa protein, consisting of four globin polypeptides each containing one heme molecule; blood acquires its red color from this heme molecule.
Eugene Khandros, Janet L. Kwiatkowski
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Hemoglobinopathies are a group of inherited blood disorders characterized by compromised hemoglobin function. Hemoglobin is a 64kDa protein, consisting of four globin polypeptides each containing one heme molecule; blood acquires its red color from this heme molecule.
Eugene Khandros, Janet L. Kwiatkowski
+4 more sources
Hematology, 2003
AbstractThe outlook for patients with sickle cell disease has improved steadily during the last two decades. In spite of these improvements, curative therapies are currently available only to a small minority of patients. The main theme of this chapter is to describe new therapeutic options that are at different stages of development that might result ...
George F, Atweh +7 more
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AbstractThe outlook for patients with sickle cell disease has improved steadily during the last two decades. In spite of these improvements, curative therapies are currently available only to a small minority of patients. The main theme of this chapter is to describe new therapeutic options that are at different stages of development that might result ...
George F, Atweh +7 more
openaire +2 more sources
Current Opinion in Pediatrics, 1993
Neonatal screening for hemoglobinopathies, coupled with comprehensive medical care that includes parental education, prophylactic penicillin, and immunizations, has markedly reduced mortality from sickle hemoglobinopathies during infancy and early childhood.
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Neonatal screening for hemoglobinopathies, coupled with comprehensive medical care that includes parental education, prophylactic penicillin, and immunizations, has markedly reduced mortality from sickle hemoglobinopathies during infancy and early childhood.
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Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: the HGB-205 trial
Nature Medicine, 2022Elisa Magrin +2 more
exaly
Major problems in internal medicine, 1977
The determination of the structure of hemoglobin is one of the milestones of molecular biology. This information has provided an intimate understanding of the way in which the molecule functions physiologically; Study of hemoglobin has proved relevant to a number of biomedical disciplines.
H F, Bunn, B G, Forget, H M, Ranney
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The determination of the structure of hemoglobin is one of the milestones of molecular biology. This information has provided an intimate understanding of the way in which the molecule functions physiologically; Study of hemoglobin has proved relevant to a number of biomedical disciplines.
H F, Bunn, B G, Forget, H M, Ranney
openaire +1 more source
The hemoglobinopathies, molecular disease mechanisms and diagnostics
International Journal of Laboratory Hematology, 2022Cornelis L Harteveld
exaly
Hemoglobinopathies are a group of severe hereditary blood diseases caused by a violation of the structure of hemoglobin or a decrease in the synthesis of one or more globin chains. The clinical picture is extremely varied. Common symptoms are hemolytic anemia, enlarged spleen, and bone damage.
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