Results 71 to 80 of about 28,606 (278)

Tocilizumab provides a potential therapeutic option for the management of hyperhaemolysis syndrome in sickle cell disease: A case series and brief narrative overview of the literature

Transfusion Medicine, EarlyView.
Abstract Background and Objectives Hyperhaemolysis syndrome is a life‐threatening complication of transfusion, potentially triggered by macrophage activation, with limited treatment options. Tocilizumab, an anti‐IL6 monoclonal antibody, has mechanistic rationale for use and has been shown to be effective in a small number of cases.
S. Wolf, B. Singh, A. Zaidi, P. Greaves, F. Oyesanya, S. Bennett, B. Kaya, F. Barroso, P. Telfer   +8 more
wiley   +1 more source

Is high pressure liquid chromatography an effective screening tool for characterization of molecular defects in hemoglobinopathies?

Indian Journal of Pathology and Microbiology, 2013
Introduction: Hemoglobinopathies constitute entities that are generated by either abnormal hemoglobin or thalassemias. high pressure liquid chromatography (HPLC) is one of the best methods for screening and detection of various hemoglobinopathies but it ...
Nikhil Moorchung, Joseph Phillip, Ravi Shankar Sarkar, Rupesh Prasad, Vibha Dutta   +4 more
doaj   +1 more source

Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients [PDF]

, 2011
Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant ...
Aboomardani, M., Arefhosseini, S.-R., Joshaghani, H., Keshtkar, A., Rafraf, M., Rashidi, M.   +5 more
core   +1 more source

Characterisation of RHD and RHCE variations in blood donors from Jazan Province, Southwestern Saudi Arabia

Transfusion Medicine, EarlyView.
Abstract Background and Objectives Rh is among the most important and highly polymorphic blood group systems due to the proximity of the RHD and RHCE genes, which encode numerous highly immunogenic antigens. However, in areas of Saudi Arabia with a high prevalence of hemoglobinopathy, the molecular characteristics of RHD and RHCE variations are lacking.
Maymoon M. Madkhali, Mayisah Khormy, Abdullah A. Meshi, Bandar Kameli, Khaled Ghazwani, Ohoud Sufyani, Salha Hakami, Yahya Khawaji, Abdullah A. Mobarki, Khaled Essawi, Waleed Hakami, Yara Alyahyawi, Aymen M. Madkhali, Gasim Dobie, Hassan A. Hamali   +14 more
wiley   +1 more source

Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies

Thalassemia Reports
Extramedullary hematopoiesis (EMH) serves as a compensatory mechanism in chronic hemolytic anemias, such as thalassemia, and can result in spinal cord compression.
Konstantinos Manganas, Aikaterini Xydaki, Angeliki Kotsiafti, Olympia Papakonstantinou, Sophia Delicou   +4 more
doaj   +1 more source

Clinical Utility of Confirmatory Genetic Testing to Differentiate Sickle Cell Trait from Sickle-β⁺-Thalassemia by Newborn Screening

International Journal of Neonatal Screening, 2020
Hemoglobin separation techniques are the most commonly used laboratory methods in newborn screening and confirmatory testing programs for hemoglobinopathies.
Lisa M. Shook, Deidra Haygood, Charles T. Quinn   +2 more
doaj   +1 more source

Epidemiological aspects of surgical site infections in an income country. The case of regional hospital center, Borgou (Benin) [PDF]

, 2017
Background: Surgical site infection is frustrating for the care team and depressing for the patient. Objective: To determine the epidemiological aspects of surgical site infections in regional hospital, Borgou.
Akpata, Robert, Allodé S., Alexandre, And Mêhinto K., Delphin, Atakpa S., Felix, Dadjo A., Yves, Fatigba O., Holden, Hodonou M., Adrien, Hounkponou-ahouingnan, Fanny, Mensah Ad, Emile, Tamou-sambo, Bio, Tobome, SEMEVO ROMARIC   +10 more
core  

Cost‐effectiveness of a hypothetical assay to evaluate stored blood quality prior to transfusion

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Unsuccessful red blood cell (RBC) transfusion, necessitating unscheduled repeat transfusion, is common and costly. Several technologies have been developed to assess stored blood quality, but the potential cost‐effectiveness of pretransfusion testing versus no testing to prevent unscheduled re‐transfusion is unknown ...
Melissa C. Caughey, Tara Templin, Nareg H. Roubinian, Matthew S. Karafin   +3 more
wiley   +1 more source

Continuum of care after newborn screening for sickle cell disease: Multinational evidence from a systematic review and meta‐analysis

British Journal of Haematology, EarlyView.
Tanveer Rehman, Srijeeta Mitra, Kalpita Ganpat Gawit, Ravindra Kumar, Sritama Dutta, Ananya Anurakta Pattanaik, Lakhan Majhee, Tanu Anand, Manisha Madkaikar, Sanghamitra Pati   +9 more
wiley   +1 more source

Emergence of red blood cell alloantibodies and transfusion management in patients with warm autoantibodies at a tertiary care centre in British Columbia, Canada

Vox Sanguinis, EarlyView.
Abstract Background and Objectives The presence of warm autoantibodies (WAAs) complicates pre‐transfusion and compatibility testing. Despite attempts to provide antigen‐matched red blood cells (RBCs), the risk of alloimmunization remains. Rates of alloimmunization and indications for transfusion were reviewed to streamline testing and RBC provision ...
S. Hutspardol, J. Mi, C. Denesiuk, D. Kalar, L. Sham, M. Roche, J. R. Tsu, D. Lam, M. T. S. Yan   +8 more
wiley   +1 more source