Results 41 to 50 of about 6,788 (312)

Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process

International Journal of Nanomedicine, 2008
Viroj WiwanitkitDepartment of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: Hemoglobin is an important protein found in the red cells of many animals. In humans, the hemoglobin is mainly distributed in the
Viroj Wiwanitkit
doaj  

Prevalence and mutations of β-thalassemia trait and abnormal hemoglobins in premarital screening in Çanakkale province, Turkey

Balkan Journal of Medical Genetics, 2016
The prevalence of β-thalassemia (β-thal) carriers in Turkey varies according to region but in general it is 2.0%. Çanakkale is a city in the Aegean region of Turkey but no study about β-thal frequency in Çanakkale has been published to date.
Uludağ A, Uysal A, Uludağ A, Ertekin YH, Tekin M, Kütük B, Silan F, Özdemir Ö   +7 more
doaj   +1 more source

Hemoglobin Subunit-Subunit Affinity-Determinant of Hemoglobin Formation [PDF]

, 1989
Hemoglobin A₂ is often elevated in β-thalassemia and decreased in α-thalassemia. This might be due to hemoglobin subunit-subunit affinity variation. It has been inferred from the study of abnormal hemoglobins that the a subunits have higher affinity for ...
Carter, Inge R., Mansouri, Ali
core   +2 more sources

Sickle cell disease status among school adolescents and their tribal community in South Gujarat [PDF]

, 2009
Objectives: to create awareness, to screen samples of school adolescents and then to reach their community through them by doing surveillance for sickle cell disease. Design: Field based cross-sectional study. Settings: St Xavier`s high school and Vanraj
Chudasama, Rajesh K, Godara, Naresh R, Srivastava, Ratan K, Vasava, Bipin   +3 more
core   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

α-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes. [PDF]

PLoS ONE, 2012
α-Thalassemia results from decreased production of α-globin chains that make up part of hemoglobin tetramers (Hb; α(2)β(2)) and affects up to 50% of individuals in some regions of sub-Saharan Africa.
Michael A Krause, Seidina A S Diakite, Tatiana M Lopera-Mesa, Chanaki Amaratunga, Takayuki Arie, Karim Traore, Saibou Doumbia, Drissa Konate, Jeffrey R Keefer, Mahamadou Diakite, Rick M Fairhurst   +10 more
doaj   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Coexistence of Relapsing Polychondritis and Sickle Cell Disease in a Child

Case Reports in Rheumatology, 2021
Relapsing polychondritis (RP) is a rare, severe connective tissue disease of unknown etiology affecting cartilaginous and proteoglycan-rich structures in an episodic and inflammatory manner.
Bernard Ofoe Tetteh, Florence-Barbara Yebuah, Maame-Boatemaa Amissah-Arthur, Dzifa Dey   +3 more
doaj   +1 more source

Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort [PDF]

, 2019
Background: Sickle cell anemia may be associated with cognitive dysfunction, and some complications of sickle cell anemia might affect those with sickle cell trait (SCT), so we hypothesized that SCT is a risk factor for cognitive impairment. Methods:
Cahill, Christina R., Cushman, Mary, Hyacinth, Hyacinth I., Irvin, Marguerite Ryan, Judd, Suzanne E., Leach, Justin M., Manly, Jennifer, McClure, Leslie A., Naik, Rakhi, Unverzagt, Frederick, Wadley, Virginia G., Winkler, Cheryl, Zakai, Neil A.   +12 more
core   +1 more source