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PAROXYSMAL COLD HEMOGLOBINURIAS
Archives of Internal Medicine, 1948DRESSLER 1 is credited with having first reported observations on a case of "paroxysmal cold hemoglobinuria," a symptom complex now known to have two separate and distinct etiologic bases. The first and more generally recognized type is syphilitic paroxysmal cold hemoglobinuria, a disease seen in a small percentage of persons with syphilis and caused ...
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Paroxysmal Cold Hemoglobinuria
CRC Critical Reviews in Clinical Laboratory Sciences, 1978The clinical and hematological features of a rare autoimmune disorder, PCH, are reviewed. Based on the case reports of 24 patients suffering from this disease, the presence of cold hemolysins in the sera of these patients as the main cause for the red cell destruction following exposure to cold is further discussed.
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Paroxysmal Nocturnal Hemoglobinuria
1992Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder of the hematopoietic stem cell (Hartmann and Arnold 1977) resulting in the production of blood cells which are defective in that they lack or are markedly deficient in glycan-phosphatidylinositol (GPI)-linked surface proteins (Rosse 1990a).
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Paroxysmal Nocturnal Hemoglobinuria in Children
Pediatric Drugs, 2007Paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematologic disorder characterized by intravascular hemolysis, nocturnal hemoglobinuria, thrombotic events, serious infections, and bone marrow failure, is very rare in children. PNH is caused by a somatic mutation of the phosphatidylinositol glycan (GPI) complementation class A (PIGA) gene ...
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Paroxysmal Nocturnal Hemoglobinuria: Biology and Treatment
Medicina (Lithuania), 2023CARLOS Bravo-Perez +2 more
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Managing Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria: A Patient-Focused Perspective
Journal of Blood Medicine, 2022Esther Natalie Oliva +2 more
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