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Paroxysmal Cold Hemoglobinuria
Hematology/Oncology Clinics of North America, 2015Paroxysmal cold hemoglobinuria is a rare cause of autoimmune hemolytic anemia predominantly seen as an acute form in young children after viral illnesses and in a chronic form in some hematological malignancies and tertiary syphilis. It is a complement mediated intravascular hemolytic anemia associated with a biphasic antibody against the P antigen on ...
Satish, Shanbhag, Jerry, Spivak
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Ravulizumab for the treatment of paroxysmal nocturnal hemoglobinuria
Expert Opinion on Biological Therapy, 2020Introduction: Eculizumab, which is indicated to treat patients with paroxysmal nocturnal hemoglobinuria (PNH), is a life-changing, life-saving therapy that decreases intravascular hemolysis and thrombosis and improves survival.
J. W. Lee, A. Kulasekararaj
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Paroxysmal Cold Hemoglobinuria
CRC Critical Reviews in Clinical Laboratory Sciences, 1978The clinical and hematological features of a rare autoimmune disorder, PCH, are reviewed. Based on the case reports of 24 patients suffering from this disease, the presence of cold hemolysins in the sera of these patients as the main cause for the red cell destruction following exposure to cold is further discussed.
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PAROXYSMAL COLD HEMOGLOBINURIAS
Archives of Internal Medicine, 1948DRESSLER 1 is credited with having first reported observations on a case of "paroxysmal cold hemoglobinuria," a symptom complex now known to have two separate and distinct etiologic bases. The first and more generally recognized type is syphilitic paroxysmal cold hemoglobinuria, a disease seen in a small percentage of persons with syphilis and caused ...
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Paroxysmal Nocturnal Hemoglobinuria
1992Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder of the hematopoietic stem cell (Hartmann and Arnold 1977) resulting in the production of blood cells which are defective in that they lack or are markedly deficient in glycan-phosphatidylinositol (GPI)-linked surface proteins (Rosse 1990a).
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Journal of the American Medical Association, 1910
History. —The patient, a woman of French extraction, aged 30, had lived in New England for the past ten years. She had been always well and strong up to the time of the present illness. There was no history of syphilis or malaria. In the fall of 1905 after exposure to cold she was seized with a severe chill which lasted one hour.
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History. —The patient, a woman of French extraction, aged 30, had lived in New England for the past ten years. She had been always well and strong up to the time of the present illness. There was no history of syphilis or malaria. In the fall of 1905 after exposure to cold she was seized with a severe chill which lasted one hour.
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