Results 101 to 110 of about 20,967 (222)

SHTXTHHly, an extracellular secretion platform for the preparation of bioactive peptides and proteins in Escherichia coli

Microbial Cell Factories, 2022
Background In previous work, we developed an E. coli extracellular secretion platform XTHHly based on the hemolysin A secretion system. It can produce bioactive peptides with simple purification procedures. However, the wider application of this platform
Wen Zhu, Yang Wang, Liangyin Lv, Hui Wang, Wenqiang Shi, Zexin Liu, Wei Yang, Jianwei Zhu, Huili Lu   +8 more
doaj   +1 more source

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen, Bingjie Wang, Jinjin Yang, Xinru Yuan, Zhixuan Chen, Can Yang, Jiana Fu, Haojin Gao, Weihua Han, Junhong Shi, Fangyou Yu, Jingyi Yu   +11 more
wiley   +1 more source

The Hemolysin B Protein, Expressed in Saccharomyces cerevisiae, Accumulates in Binding‐Protein(BiP)‐Containing Structures [PDF]

European Journal of Biochemistry, 1996
The hemolysin B (HlyB) protein of Escherichia coli, a member of the ABC‐transporter family, was expressed in Saccharomyces cerevisiae and tested for its ability to complement a defect in the a‐factor transporter Ste6. We found that HlyB was not able to restore mating ability to a STE6 deletion strain.
R, Kölling, C P, Hollenberg
openaire   +2 more sources

Mycobacterial tlyA gene product is localized to cell-wall without signal sequence.

Frontiers in Cellular and Infection Microbiology, 2015
The mycobacterial tlyA gene product, Rv1694 (MtbTlyA), has been annotated as 'hemolysin' which was re-annotated as 2'-O rRNA methyl transferase. In order to function as a hemolysin, it must reach extracellular milieu with the help of signal sequence(s ...
Santosh eKumar, Ekansh eMittal, Sapna eDeore, Anil eKumar, Aejazur eRahman, Krishnasastry V Musti   +5 more
doaj   +1 more source

Let There be Light! Light as an Engine and Regulator in Synthetic Cells

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
Cells are out‐of‐equilibrium systems that regulate their spatiotemporal features. In biomimetic synthetic cells, light offers a unique way for energizing and regulating events in space and time. This review explores the implementation of light‐responsive tools in synthetic cells to replicate biological functions and enable new bioinspired behaviors ...
Matthew E. Allen, Saskia Frank, Mehaiarii Louis, Atreyee Saha, Ali Heidari, Seraphine V. Wegner   +5 more
wiley   +1 more source

Decoding Aquaculture's Future: A Review of Molecular Docking and Simulation in Enhancing Growth and Disease Resistance

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT Aquaculture has overtaken capture fisheries as the main source of aquatic animal protein, marking a critical step in global food security. Yet, rapid intensification faces major challenges, including disease outbreaks, environmental degradation, and dependence on wild‐caught fish for feed.
Suvadip Ghara, Iyyappan Somasundaram, Mohd Ashraf Rather, Mukilan Aakash, Mary Divya B, Irfan Ahmad Bhat, Irfan Ahmad Khan, Vlastimil Stejskal, Elayaraja Sivaramasamy   +8 more
wiley   +1 more source

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

E. coli a-hemolysin: a membrane-active protein toxin

Brazilian Journal of Medical and Biological Research, 1998
Alpha-Hemolysin is synthesized as a 1024-amino acid polypeptide, then intracellularly activated by specific fatty acylation. A second activation step takes place in the extracellular medium through binding of Ca2+ ions. Even in the absence of fatty acids and Ca2+ HlyA is an amphipathic protein, with a tendency to self-aggregation. However, Ca2+-binding
Goñi, F.M., Ostolaza, H.
openaire   +3 more sources

Restraining Staphylococcus aureus Virulence Factors and Quorum Sensing through Lactic Acid Bacteria Supernatant Extracts

Antibiotics
The escalating prevalence of antibiotic-resistant bacteria poses a grave threat to human health, necessitating the exploration of novel alternatives to conventional antibiotics.
Myriam Anabel Díaz, Esteban Gabriel Vega-Hissi, María Amparo Blázquez, María Rosa Alberto, Mario Eduardo Arena   +4 more
doaj   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source