Results 141 to 150 of about 89,871 (313)

Bioengineering Platelets Presenting PD‐L1, Galectin‐9 and BTLA to Ameliorate Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
IFN‐γ‐primed platelets enriched with immunosuppressive ligands (PD‐L1, PD‐L2, BTLA, and Gal‐9) are shown to induce T cell exhaustion and apoptosis, preserving β‐cell function and preventing hyperglycemia progression in type 1 diabetes. IFN‐γ platelets also promote Treg expansion, macrophage polarization, and β‐cell proliferation, offering a promising ...
Yumeng Ma   +14 more
wiley   +1 more source

Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex

open access: yesAdvanced Science, EarlyView.
Cu2Ir NPs based on a Cu‐porphyrin core and cyclometalated Ir(III) substituents achieve combined endogenous peroxynitrite‐triggered NIR chemiluminescence imaging, PTT and PDT for successfully achieving safe thrombolysis, antioxidant and anti‐inflammatory multifunctionality in one single molecule.
Ziwei Wang   +13 more
wiley   +1 more source

HMAMP: Hypervolume-Driven Multi-Objective Antimicrobial Peptides Design [PDF]

open access: yesarXiv
Antimicrobial peptides (AMPs) have exhibited unprecedented potential as biomaterials in combating multidrug-resistant bacteria. Despite the increasing adoption of artificial intelligence for novel AMP design, challenges pertaining to conflicting attributes such as activity, hemolysis, and toxicity have significantly impeded the progress of researchers.
arxiv  

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

open access: yesAdvanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang   +6 more
wiley   +1 more source

PepDoRA: A Unified Peptide Language Model via Weight-Decomposed Low-Rank Adaptation [PDF]

open access: yesarXiv
Peptide therapeutics, including macrocycles, peptide inhibitors, and bioactive linear peptides, play a crucial role in therapeutic development due to their unique physicochemical properties. However, predicting these properties remains challenging.
arxiv  

A Universal and Versatile Zwitterionic Coating for Blood‐Contacting Catheters with Long Lengths and Complex Geometries

open access: yesAdvanced Science, EarlyView.
A universal and versatile zwitterion coating strategy is developed for blood‐contacting catheters with long lengths and complex geometries. The coating exhibits near‐zero fouling, superior anticoagulation, and selective biocapturing properties while maintaining excellent stability under dynamic blood flow.
Tong Zhang   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy