Results 51 to 60 of about 37,157 (276)

Linking preclinical models to clinical realities: VEGF/VEGFR inhibitors and thrombotic microangiopathy in cancer therapy

iMetaOmics, EarlyView.
This study investigates the risk of thrombotic microangiopathy (TMA) induced by vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) inhibitors in cancer therapy. Using data from the FDA Adverse Event Reporting System (FAERS), the WHO Global Database for Adverse Drug Reactions (Vigibase), and The Cancer ...
Aimin Jiang, Zhanzhi Li, Ying Liu, Junyi Shen, Quan Cheng, Anqi Lin, Peng Luo, Linhui Wang   +7 more
wiley   +1 more source

Case Series of 3 Patients Diagnosed With Atypical Hemolytic Uremic Syndrome Successfully Treated With Steroids, Plasmapheresis, and Rituximab

Canadian Journal of Kidney Health and Disease, 2017
Rationale: Atypical hemolytic uremic syndrome, which has a high probability of chronic kidney disease, morbidity, and mortality, needs to be promptly recognized when patients present with microangiopathic hemolysis.
Jeffery M. Patterson, Lauren Bolster, Loree Larratt   +2 more
doaj   +1 more source

Pregnancy-Associated Atypical Hemolytic-Uremic Syndrome

American Journal of Perinatology Reports, 2016
Précis Introduction Early diagnosis of atypical uremic–hemolytic syndrome may be challenging during the puerperium period. Correct diagnosis and timely management are crucial to improve outcomes.
Antonio F. Saad, Jorge Roman, Aaron Wyble, Luis D. Pacheco   +3 more
doaj   +1 more source

Indication‐Specific Dosing and Dose‐Evaluation Strategies in New Indications for Non‐Oncology Monoclonal Antibodies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley   +1 more source

Enterohemorrhagic Escherichia coli with particular attention to the German outbreak strain O104:H4 [PDF]

, 2012
This review deals with the epidemiology and ecology of enterohemorrhagic Escherichia coli (EHEC), a subset of the verocytotoxigenic Escherichia coli (VTEC), and subsequently discusses its public health concern.
De Reu, K, De Zutter, Lieven, Joris, Adelheid, Vanrompay, Daisy, Verstraete, K   +4 more
core   +1 more source

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland [PDF]

, 2012
Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections.
Allison, L.J., Caprioli, A., Chase-Topping, M.E., Courcier, E., Evans, J., Gally, D.L., Handel, I., Hanson, M.F., Karch, H., Locking, M.E., Low, J.C., Matthews, L., McKendrick, I.J., Pearce, M.C., Pollock, K.J., Rosser, T., Woolhouse, M.E.J.   +16 more
core   +5 more sources

Management of hemolytic uremic syndrome [PDF]

F1000Prime Reports, 2014
Hemolytic uremic syndrome (HUS) is a disease characterized by hemolysis, thrombocytopenia, and acute kidney injury, although other organs may be involved. Most cases are due to infection with Shiga toxin-producing Escherichia coli (STEC). Early identification and initiation of best supportive care, with microbiological input to identify the pathogen ...
Kavanagh D, Raman S, Sheerin NS
openaire   +4 more sources

Síndrome hemolítico-urémico.

Acta Médica Portuguesa, 1999
The microangiopathic thrombotic syndromes--thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS)--are characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal dysfunction, fever and central nervous system ...
P A Rodrigues, J Machado, O Cardoso, J Cruz, F Carvalho, M da Costa, R Proença   +6 more
doaj   +1 more source

Forging a New Frontier: Antimicrobial Peptides and Nanotechnology Converging to Conquer Gastrointestinal Pathogens

Small, EarlyView.
This review explores the potential of antimicrobial peptides (AMPs) and nanotechnology for the treatment of gastrointestinal infections. It analyzes bacterial resistance mechanisms, the antimicrobial actions of AMPs, and advances in nanocarriers, such as lipid‐based, polymeric, metallic, and mesoporous silica systems, that enhance peptide protection ...
Christian Shleider Carnero Canales, Cesar Augusto Roque‐Borda, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Uner Josseph Pinto Apaza, Vanderson de Jesus Silva, Laura Maria Duran Gleriani Primo, Maura Jennifer Martínez‐Morales, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +10 more
wiley   +1 more source