Results 121 to 130 of about 5,885,878 (288)

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Expression, purification and hemolytic activity of rL-hemolysin proteins.

, 2013
(A). Hemolysin genes amplified from genomic DNA of L. interrogans strain Lai. Lane AM: DNA marker (Fermentas, Canada). Lane A1: blank control. Lanes A2 to A9: amplicons of the sph1 (1674 bp), sph2 (1869 bp), sph3 (1557 bp), sph4 (717 bp), hlpA (939 bp ...
Yifei Wu (313108), Xu’ai Lin (313111), Jie Yan (119530), Shibiao Ding (313110), Huan Wang (109286), Chenglin Zhang (313109), David M. Ojcius (167589), X. Frank Yang (215426)   +7 more
core   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Hemolytic Activities of the Candida Species in Liquid Medium

Eurasian Journal of Medicine, 2019
Objective. The aim of this study was to evaluate the in vitro hemolytic activities of 107 Candida strains isolated from different clinical samples in liquid medium, and to examine the impact of glucose on this activity. Materials and Methods.
Hilal Kuzucu Malcok, Esin Aktas, Ahmet Ayyildiz, Nimet Yigit, Halil Yazgi   +4 more
doaj  

Bacteriocin-like Inhibitory Activity Associated with Beta-hemolytic Strains of Streptococcus salivarius

, 1987
Seven beta-hemolytic Streptococcus salivarius isolates produced bacteriocin-like inhibitory activity in deferred antagonism tests using a set of nine indicator bacteria (I1-I 9). Five of these S.
G.R. Tompkins, J.R. Tagg
core   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Erythrocyte Vulnerability to Airborne Nanopollutants

Toxics
The toxicological impact of airborne polluting ultrafine particles (UFPs, also classified as nanoparticles with average sizes of less than 100 nm) is an emerging area of research pursuing a better understanding of the health hazards they pose to humans ...
Cristina Hermosillo-Abundis, Aracely Angulo-Molina, Miguel A. Méndez-Rojas   +2 more
doaj   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Isolation and Characterization of Photosensitive Hemolytic Toxins from the Mixotrophic Dinoflagellate Akashiwo sanguinea

Marine Drugs
The mixotrophic dinoflagellate Akashiwo sanguinea is known to have acute toxic effects on multiple marine organisms, while the composition and chemical properties of its toxins remain unclear.
Jiling Pan, Ting Fang, Shuang Xie, Ning Xu, Ping Zhong   +4 more
doaj   +1 more source

Non-hemolytic activity of ntATX-D1 and ntATX-D2.

The hemolytic activity of purified ntATX-D1 and ntATX-D2 was evaluated using 5% defibrinated sheep blood agar plates. Wells were punched into the agar and loaded with 30 μL of purified proteins (10 μg/well) and incubated at 37°C overnight. The absence of
Feba Ann John (18462177), Anil J. Thachil (8011409), Jennifer Holmes (9235173), Raveendra R. Kulkarni (18462189), Valeria Criollo (18462180), Carissa Gaghan (18462183), Abigail Armwood (18462186), Rocio Crespo (669546)   +7 more
core   +1 more source