Results 111 to 120 of about 5,885,878 (288)

Extended Antimicrobial Profile of Chromone–Butenafine Hybrids

Molecules
Fungal infections are recognized as a global health issue, in particular considering the spread of different forms of resistance to the commonly used antifungal drugs and their involvement in the occurrence of co-infections in hospitalized and ...
Francesca Bonvicini, Lisa Menegaldo, Rebecca Orioli, Federica Belluti, Giovanna Angela Gentilomi, Silvia Gobbi, Alessandra Bisi   +6 more
doaj   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Spontaneous hemolytic activity of rat alveolar lining material.

, 1988
International audienceDuring assays of the complement hemolytic activity in lavage fluids (LF) from humans and various laboratory animals (hamsters, rabbits, rats, guinea pigs), we have observed that rat bronchoalveolar lavages had a spontaneous ...
Quesneau-Guilmont, B., Bignon, J., Masliah, J., Lambré, C. R., Alcindor, L. G.   +4 more
core   +2 more sources

Synthesis and Hemolytic Activity of Bile Acid-Indole Bioconjugates Linked by Triazole. [PDF]

J Org Chem, 2023
Berdzik N, Koenig H, Mrówczyńska L, Nowak D, Jasiewicz B, Pospieszny T.   +5 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Cecropin A-magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect

, 1998
In order to obtain peptides having improved antimicrobial activity with low hemolytic effect, a hybrid peptide (CA-MA) composed from cecropin A(1-8) and magainin 2(1-12), and its analogues with amino acid substitutions were designed and synthesized.
Yang Mee Kim, Myung Kyu Lee, Sun Young Kim, Kyung Soo Hahm, Song Yub Shin, Joo Hyun Kang   +5 more
core   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Ply Hemolytic Activity.

, 2013
Hemolytic activity of Ply was measured in the presence of 2% RBCs. The results are shown as relative % hemolysis. RBCs and 1% TX100 served as the positive control and represents 100% lysis.
Mary E. Marquart (399869), Melissa E. Sanders (399864), Larry S. McDaniel (399868), Sidney D. Taylor (399863), Nathan A. Tullos (399865), Stephen J. Stray (399866), Erin W. Norcross (399867)   +6 more
core   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

Searching for Virulence Factors among Staphylococcus lugdunensis Isolates from Orthopedic Infections: Correlation of β-hemolysin, hemolysin III, and slush Genes with Hemolytic Activity and Synergistic Hemolytic Activity. [PDF]

Int J Mol Sci, 2023
Ravaioli S, Campoccia D, Mirzaei R, Mariani V, Bottau G, De Donno A, Montanaro L, Speziale P, Arciola CR.   +8 more
europepmc   +1 more source