Results 91 to 100 of about 6,154,219 (251)

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Antibacterial and hemolytic activity of synthetic B1CTcu5 and SMMD analogs.

, 2015
a—MIC represents the lowest peptide concentration required to kill entire bacteria, NA-not active up to the highest concentration tested.Antibacterial and hemolytic activity of synthetic B1CTcu5 and SMMD analogs.
Asha R (742959), Anand Sundaram (742958), Reshmy V (742960), K. Santhosh Kumar (742962), Parvin Abraham (742957), Sanil George (742961)   +5 more
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Prediction of hemolytic peptides and their hemolytic concentration

Communications Biology
Peptide-based drugs often fail in clinical trials due to their toxicity or hemolytic activity against red blood cells (RBCs). Existing methods predict hemolytic peptides but not the concentration (HC50) required to lyse 50% of RBCs.
Anand Singh Rathore, Nishant Kumar, Shubham Choudhury, Naman Kumar Mehta, Gajendra P. S. Raghava   +4 more
doaj   +1 more source

Unfavorable amino acid substitutions of Cap18 leading to increased hemolytic activity against horse erythrocytes.

, 2018
Unfavorable amino acid substitutions of Cap18 leading to increased hemolytic activity against horse erythrocytes.
Frank Møller Aarestrup (238770), Egon Bech Hansen (836736), Anna Ebbensgaard (836732), Hanne Mordhorst (836733), Michael Toft Overgaard (836734)   +4 more
core   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

A comparison of pneumolysin activity and concentration in vitro and in vivo in a rabbit endophthalmitis model

Clinical Ophthalmology, 2008
Melissa E Sanders1, Erin W Norcross1, Quincy C Moore III1, Chinwendu Onwubiko1, Lauren B King1, et al1Department of Microbiology; 2Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USAAbstract: The purpose of this ...
Melissa E Sanders, Erin W Norcross, Quincy C Moore III, Chinwendu Onwubiko, Lauren B King, et al   +5 more
doaj  

Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis

The Korean Journal of Gastroenterology
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction.
Syedda Ayesha, Masood Muhammad Karim, Maria Ali, Abdul Hadi Shahid, Salman Naseem Adil   +4 more
doaj   +1 more source

Rice Phyllosphere Bacillus Species and Their Secreted Metabolites Suppress Aspergillus flavus Growth and Aflatoxin Production In Vitro and In Maize Seeds

Toxins, 2018
The emergence of super-toxigenic strains by recombination is a risk from an intensive use of intraspecific aflatoxin (AF) biocontrol agents (BCAs). Periodical alternation with interspecific-BCAs will be safer since they preclude recombination.
Subbaiah Chalivendra, Catherine DeRobertis, Jorge Reyes Pineda, Jong Hyun Ham, Kenneth Damann   +4 more
doaj   +1 more source

Hemolytic activity of TRH variants and TDH2 expressed in a cell-free system.

, 2015
Approx. 300 ng of soluble protein were combined with 4% erythrocyte suspension of each blood type respectively. Hemolytic activity was determined by spectro-photometrical measurement at OD570 and set in proportion (%) to the maximum hemolysis in the ...
Susanne Diescher (709766), Doreen A. Wüstenhagen (500409), Claudia Jäckel (671897), Stefan Kubick (500410), Silke Bechlars (709765), Ralf Dieckmann (709767), Eckhard Strauch (57879)   +6 more
core   +1 more source