Results 31 to 40 of about 5,885,878 (288)

Increased Risk of Thrombocytopenia and Death in Patients with Bacteremia Caused by High Alpha Toxin-Producing Methicillin-Resistant Staphylococcus aureus

Toxins, 2021
Alpha toxin (Hla) is a major virulence factor of Staphylococcus aureus that targets platelets but clinical data on Hla pathogenesis in bacteremia (SAB) is limited. We examined the link between in vitro Hla activity and outcome.
Fatimah Alhurayri, Edith Porter, Rachid Douglas-Louis, Emi Minejima, Juliane Bubeck Wardenburg, Annie Wong-Beringer   +5 more
doaj   +1 more source

Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells [PDF]

PeerJ, 2018
Two novel peptides belonging to the dermaseptin family, namely DRS-CA-1 and DRS-DU-1, were encoded from cDNA libraries derived from the skin secretions of Phyllomedusa camba and Callimedusa (Phyllomedusa) duellmani.
Haohao Zhu, Xiyan Ding, Wei Li, Tulin Lu, Chengbang Ma, Xinping Xi, Lei Wang, Mei Zhou, Roberta Burden, Tianbao Chen   +9 more
doaj   +2 more sources

Differential expression of hemolysin genes in weakly and strongly hemolytic Brachyspira hyodysenteriae strains

BMC Veterinary Research, 2020
Background Swine dysentery (SD) is a diarrheal disease in fattening pigs that is caused by the strongly hemolytic species Brachyspira (B.) hyodysenteriae, B. hampsonii and B. suanatina. As weakly hemolytic Brachyspira spp. are considered less virulent or
Jessica Joerling, Hermann Willems, Christa Ewers, Werner Herbst   +3 more
doaj   +1 more source

Cell-associated hemolysis activity in the clinical strain of Pseudomonas fluorescens MFN1032

BMC Microbiology, 2010
Background MFN1032 is a clinical Pseudomonas fluorescens strain able to grow at 37°C. MFN1032 cells induce necrosis and apoptosis in rat glial cells at this temperature. This strain displays secretion-mediated hemolytic activity involving phospholipase C
Feuilloley Marc GJ, Orange Nicole, Connil Nathalie, Guerillon Josette, Rossignol Gaelle, Sperandio Daniel, Merieau Annabelle   +6 more
doaj   +1 more source

Mechanism of Low Hemolytic Activity of Alkyl Type Nonphosphorous Cationic Glycerolipids: Study on Model Membranes

Клиническая онкогематология, 2014
Nonphosphorous alkyl cationic glycerolipids cause death of tumor cells with minimal damage of erythrocytes. In this article we demonstrate, that low hemolytic activity of these compounds can be explained by their weak ability to damage the integrity of ...
A. A. Markova, S. A. Okorochenkov, N. V. Plyavnik, A. A. Shtil   +3 more
doaj   +1 more source

Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes.
Lorena Rocha Ayres, Alex dos Reis Récio, Sandra Mara Burin, Juliana Campos Pereira, Andrea Casella Martins, Suely Vilela Sampaio, Fabíola Attié de Castro, Luciana Simon Pereira-Crott   +7 more
doaj   +1 more source

Iron-Regulated Phospholipase C Activity Contributes to the Cytolytic Activity and Virulence of Acinetobacter baumannii. [PDF]

PLoS ONE, 2016
Acinetobacter baumannii is an opportunistic Gram-negative pathogen that causes a wide range of infections including pneumonia, septicemia, necrotizing fasciitis and severe wound and urinary tract infections. Analysis of A.
Steven E Fiester, Brock A Arivett, Robert E Schmidt, Amber C Beckett, Tomislav Ticak, Mary V Carrier, Rajarshi Ghosh, Emily J Ohneck, Maeva L Metz, Marlo K Sellin Jeffries, Luis A Actis   +10 more
doaj   +1 more source

Anti-Trypanosoma cruzi activity, cytotoxicity and, chemical characterization of extracts from seeds of Lonchocarpus cultratus

Journal of Infection in Developing Countries, 2021
Introduction: Trypanosoma cruzi is the agent of Chagas’ disease and affects approximately 6-8 million people worldwide. The search for new anti-T. cruzi drugs are relevant because only two drugs exist actually.
Aline Griebler, Fernanda Weyand Banhuk, Izabela Virginia Staffen, Aline Antunes Maciel Bortoluzzi, Thaís Soprani Ayala, Rinaldo Ferreira Gandra, Ivânia Teresinha Albrecht Schuquel, Edson Antonio Alves da Silva, Tereza Cristina Marinho Jorge, Rafael Andrade Menolli   +9 more
doaj   +1 more source

Hemolytic Activity of Aminoethyl-dodecanoates

Zeitschrift für Naturforschung C, 1998
Abstract The effect of new lysosomotropic compounds on red blood cell hemolysis and erythrocyte membrane fluidity has been investigated. In earlier studies it was shown that the compounds inhibit the growth of yeast and plasma membrane H+-ATPase activity.
H, Kleszczyńska, J, Luczyński, S, Witek, S, Przestalski   +3 more
openaire   +2 more sources

Prevalence of virulence factors in Staphylococcus intermedius isolates from dogs and pigeons

BMC Veterinary Research, 2006
Background Staphylococcus intermedius has been isolated from healthy dogs and pigeons as well as diseased dogs. Similar to Staphylococcus aureus, S. intermedius is known to carry many virulence factors but most of these factors remain to be studied.
Fukuyasu Tsuguaki, Sakurai Naomi, Ba-Thein William, Futagawa-Saito Keiko   +3 more
doaj   +1 more source