Results 41 to 50 of about 11,283,851 (345)

Mechanism of Low Hemolytic Activity of Alkyl Type Nonphosphorous Cationic Glycerolipids: Study on Model Membranes

Клиническая онкогематология, 2014
Nonphosphorous alkyl cationic glycerolipids cause death of tumor cells with minimal damage of erythrocytes. In this article we demonstrate, that low hemolytic activity of these compounds can be explained by their weak ability to damage the integrity of ...
A. A. Markova, S. A. Okorochenkov, N. V. Plyavnik, A. A. Shtil   +3 more
doaj   +1 more source

Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity.

Colloids and Surfaces B: Biointerfaces, 2017
Antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against a wide range of bacteria, fungi and viruses. For an AMP to be considered as a therapeutic option, it must have not only potent antibacterial properties
P. Maturana, Melina M. B. Martínez, M. Noguera, Nuno C. Santos, E. A. Disalvo, L. Semorile, P. Maffia, A. Hollmann   +7 more
semanticscholar   +1 more source

Iron-Regulated Phospholipase C Activity Contributes to the Cytolytic Activity and Virulence of Acinetobacter baumannii. [PDF]

PLoS ONE, 2016
Acinetobacter baumannii is an opportunistic Gram-negative pathogen that causes a wide range of infections including pneumonia, septicemia, necrotizing fasciitis and severe wound and urinary tract infections. Analysis of A.
Steven E Fiester, Brock A Arivett, Robert E Schmidt, Amber C Beckett, Tomislav Ticak, Mary V Carrier, Rajarshi Ghosh, Emily J Ohneck, Maeva L Metz, Marlo K Sellin Jeffries, Luis A Actis   +10 more
doaj   +1 more source

Anti-Trypanosoma cruzi activity, cytotoxicity and, chemical characterization of extracts from seeds of Lonchocarpus cultratus

Journal of Infection in Developing Countries, 2021
Introduction: Trypanosoma cruzi is the agent of Chagas’ disease and affects approximately 6-8 million people worldwide. The search for new anti-T. cruzi drugs are relevant because only two drugs exist actually.
Aline Griebler, Fernanda Weyand Banhuk, Izabela Virginia Staffen, Aline Antunes Maciel Bortoluzzi, Thaís Soprani Ayala, Rinaldo Ferreira Gandra, Ivânia Teresinha Albrecht Schuquel, Edson Antonio Alves da Silva, Tereza Cristina Marinho Jorge, Rafael Andrade Menolli   +9 more
doaj   +1 more source

Hemolytic Activity of a Togavirus, Getah* [PDF]

Microbiology and Immunology, 1979
AbstractA purified toga‐alphavirus, Getah (GET), showed optimal hemolytic activity for one‐day‐old chick red blood cells when incubated at 37 C for 120 min at pH 6.2. Experimental data obtained from various angles, such as pH dependency, inhibition by virus‐specific antiserum and by concanavalin A, indicated that the hemolysis was a property of the ...
Y, Yoshinaka, S, Okada, T, Shiomi
openaire   +2 more sources

Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes.
Lorena Rocha Ayres, Alex dos Reis Récio, Sandra Mara Burin, Juliana Campos Pereira, Andrea Casella Martins, Suely Vilela Sampaio, Fabíola Attié de Castro, Luciana Simon Pereira-Crott   +7 more
doaj   +1 more source

Nutrient Alteration Drives the Impacts of Seawater Acidification on the Bloom-Forming Dinoflagellate Karenia mikimotoi

Frontiers in Plant Science, 2021
Seawater acidification and nutrient alteration are two dominant environmental factors in coastal environments that influence the dynamics and succession of marine microalgae. However, the impacts of their combination have seldom been recorded.
Qian Liu, Qian Liu, Yanqun Wang, Yuanyuan Li, Yijun Li, You Wang, You Wang, Bin Zhou, Bin Zhou, Zhongyuan Zhou, Zhongyuan Zhou   +10 more
doaj   +1 more source

THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI [PDF]

Journal of Experimental Medicine, 1933
Broth cultures of hemolytic streptococci derived from patients are capable of rapidly liquefying normal human fibrin clot. The active fibrinolytic principle is also contained in sterile, cell-free filtrates of broth cultures. The degree of activity of filtrates parallels the activity of whole broth cultures sufficiently closely to ...
W S, Tillett, R L, Garner
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Anti-hemolytic, antibacterial and anti-cancer activities of methanolic extracts from leaves and stems of Polygonum odoratum

Asian Pacific Journal of Tropical Biomedicine, 2018
Objective: To investigate anti-hemolytic, antibacterial and anti-cancer activities of leaf and stem extracts from Polygonum odoratum. Methods: Leaves and stems of Polygonum odoratum were extracted using methanol and their anti-hemolytic activity was ...
Nittaya Chansiw, Narisara Paradee, Kamonnaree Chotinantakul, Somdet Srichairattanakool   +3 more
doaj   +1 more source