Results 81 to 90 of about 33,878 (223)

Eculizumab for Gemcitabine-Induced Hemolytic Uremic Syndrome: A Novel Therapy for an Emerging Condition [PDF]

, 2015
Introduction Atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA), is a disease characterized by hemolytic anemia, thrombocytopenia, and renal impairment. Gemcitabine, a commonly used chemotherapy, is emerging as a cause of aHUS.
Karkowsky, MD, Raphael, Parikh, MD, Kinjal   +1 more
core   +2 more sources

Organ Crosstalk During Injury: Mechanisms of Lung–Kidney Interaction in Critical Illness

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Crosstalk between the lungs and kidneys may propagate multiorgan injury in critically ill patients. This review examines evidence of crosstalk between the lungs and kidneys after injury, focusing on translational and mechanistic studies. Pathophysiology and animal models of acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) are ...
Kathryn M. Sullivan, Kathleen D. Liu, Michael A. Matthay   +2 more
wiley   +1 more source

The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease [PDF]

, 2015
Atypical hemolytic uremic syndrome (aHUS) is characterized by complement attack against host cells due to mutations in complement proteins or autoantibodies against complement factor H (CFH).
Abarrategui-Garrido, Adams, Adrian Goldman, Arnab Bhattacharjee, Baker, Barbara Uzonyi, Bhattacharjee, Bhattacharjee, Blanc, Blaum, Castiblanco-Valencia, Dragon-Durey, Dragon-Durey, Dragon-Durey, Emsley, Eszter Trojnár, Eyler, Ferreira, Freddo, Fritzler, Goicoechea de Jorge, Harald Seeberger, Hebecker, Heinen, Herbert, Herbert, Hofer, Holmes, Jokiranta, Józsi, Józsi, Józsi, Kabsch, Kajander, Lehtinen, Manuelian, McCarthy, McCoy, Meri, Mihály Józsi, Moore, Morgan, Noris, Oppermann, Pangburn, Robert Kolodziejczyk, Roumenina, Satu Hyvärinen, Sinha, Stefanie Reuter, Strobel, Strobel, Sánchez-Corral, Sánchez-Corral, T. Sakari Jokiranta, Venables, Zipfel, Zipfel, Zoltán Prohászka, Ágnes Szilágyi   +59 more
core   +1 more source

Comparison of Two Strategies of Analysis of Urinary Protein Composition for the Diagnosis and Follow‐Up of Renal Diseases

ELECTROPHORESIS, Volume 46, Issue 23, Page 1673-1680, December 2025.
ABSTRACT Proteinuria analysis is necessary to detect the early stages of kidney disease before the estimated glomerular filtration rate deteriorates and to monitor the progression of treated kidney disease. Electrophoresis is often the first orientation test, although this test is time‐consuming and its interpretation may be subjective.
Joris Guyon, Jeanne Malaubier, Hong‐Van Pham, Lila Rami Arab, Laurence Pieroni, Marie‐Laure Curutchet‐Burtin, Rémi Segues, Sylvie Caspar‐Bauguil, Annie M. Bérard   +8 more
wiley   +1 more source

Safety and efficacy of eculizumab in adult and pediatric patients with aHUS, with or without baseline dialysis [PDF]

, 2015
C
Hourmant, Maryvonne, Kincaid, John F, Legendre, Christophe M, Menne, Jan, van de Kar, Nicole CAJ, Vande Walle, Johan   +5 more
core   +1 more source

Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland [PDF]

, 2017
Factor H autoantibodies can impair complement regulation, resulting in atypical hemolytic uremic syndrome, predominantly in childhood. There are no trials investigating treatment, and clinical practice is only informed by retrospective cohort ...
Almond, M, Awan, A, Booth, C, Brocklebank, V, Finlay, E, Fitzpatrick, M, Gilbert, RD, Goodship, TH, Hegde, S, Inward, C, Johnson, S, Kaur, A, Kavanagh, D, Kerecuk, L, Kinoshita, M, Marchbank, KJ, Marks, SD, Salama, AD, Sheerin, NS, Sheerin, TP, Tyerman, K, Walsh, PR, Webb, N, Wong, EKS   +23 more
core   +1 more source

Soluble C5b‐9 (sC5b‐9) in Pediatrics—A Clinical Assessment

Journal of Clinical Laboratory Analysis, Volume 39, Issue 23, December 2025.
The sc5b9 assay is a simple laboratory‐developed test that can be used in specific patients to monitor the course of disease, severity, or response to therapy. Future studies using this assay, which show excellent adaptability to a clinical laboratory, will reveal the multiple uses of testing for complement activation.
Ridwan B. Ibrahim, Radwa Almamoun, Sarah E. Sartain, Sridevi Devaraj   +3 more
wiley   +1 more source

Atypical haemolytic-uraemic syndrome caused by factor H mutation: case report and new management strategies in children [PDF]

, 2012
Atypical haemolytic uraemic syndrome is causedby alternative complement pathway dysregulation. It has recently been recognised that most cases are due to genetic factors and a growing list of mutations has been described.
Araújo, L., Barbot, J., Costa, T., Faria, M., Mota, C., Rocha, L.   +5 more
core  

Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex [PDF]

, 2016
Introduction Coagulation and complement systems are simultaneously activated at sites of tissue injury, leading to thrombin generation and opsonisation with C3b.
Baerga-Ortiz, Bajzar, Boehme, Bossi, Campbell, Conway, de Córdoba S, Delvaeye, Dragon-Durey, Esmon, Esmon, Esmon, Esparza-Gordillo, Faust, Fuentes-Prior, Gordon, Hakobyan, Hamad, Harris, Heurich, Hindmarsh, Honda, Huntington, Ikeda, Ito, Jokiranta, Kavanagh, Li, Light, Maga, Markiewski, Martinez-Barricarte, Mayer, Meri, Mizuno, Moll, Morgan, Mouksassi, Noris, Owen, Pangburn, Sadler, Sadler, Saito, Salem, Sawada, Schramm, Shental-Bechor, Suzuki, Tateishi, Tortajada, Udagawa, Vincent, Walport, Walport, Wu, Yada, Yamamoto, Zushi   +58 more
core   +2 more sources

Antitumor Compounds From Halophilic Streptomyces violaceorubidus M4 Against Triple‐Negative Breast Cancer

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The antitumor effects of the halophilic Streptomyces violaceorubidus M4 extract on triple‐negative breast cancer, highlighting its selective cytotoxicity and apoptosis‐inducing properties. Key findings include the identification of bioactive compounds and their impact on apoptosis‐related gene expression, as well as significant reductions in tumor cell
Atousa Zia, Ensieh Salehghamari, Hanieh Jalali, Maryam Taher   +3 more
wiley   +1 more source