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Hemophagocytic Lymphohistiocytosis
AACN Advanced Critical Care, 2019Hemophagocytic lymphohistiocytosis is a life-threatening condition associated with hyperinflammation and multiple organ dysfunction. It has many causes, symptoms, and outcomes. Early recognition is critical for treatment. Fever, cytopenias, coagulopathy, and hepatosplenomegaly are hallmark findings.
Janice, Skinner +2 more
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Hemophagocytic Lymphohistiocytosis in Children
The Indian Journal of Pediatrics, 2020To study the profile of children with Hemophagocytic Lymphohistiocytosis (HLH) in a tertiary care hospital for children.A retrospective analysis of case records of 52 children diagnossed with HLH was performed.Of the 52 children 13% (n = 7) had Familial HLH and 87% (n = 45) had secondary HLH (sHLH). Common manifestations were fever (100%), organomegaly
Divya Nandhakumar +4 more
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Hemophagocytic lymphohistiocytosis in adults
Leukemia & Lymphoma, 2018Hemophagocytic lymphohistiocytosis (HLH), a rare but life-threatening condition characterized by uncontrolled inflammation, is increasingly recognized in adults. The management of adult onset HLH is challenging, in part due to gaps in current state of knowledge on etiology, clinical presentation, diagnosis, and management.
Neel S, Bhatt +2 more
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An Overview of Hemophagocytic Lymphohistiocytosis
Pediatric Annals, 2017Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by a dysregulated hyperinflammatory response associated with aberrant activation of lymphocytes and macrophages that results in hypercytokinemia. It is classically divided into two types: (1) primary or familial HLH and (2) secondary HLH.
Ysabella M, Esteban +2 more
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Pathogenesis of Hemophagocytic Lymphohistiocytosis
Hematology/Oncology Clinics of North America, 2015Hemophagocytic Lymphohistiocytosis (HLH), an inherited life-threatening inflammatory disorder, has gained growing recognition not only in children but also increasingly in adults over the past 2 decades. HLH involves inborn defects in lymphocytes, which normally mediate control of infectious and inflammatory conditions within the immune system and in ...
Alexandra H, Filipovich +1 more
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Hemophagocytic Lymphohistiocytosis in Adults
Hematology/Oncology Clinics of North America, 2015Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal syndrome of pathologic immune dysregulation characterized by clinical signs and symptoms of extreme inflammation. HLH can occur as a genetic or sporadic disorder and, though seen as an inherited condition affecting primarily a pediatric population, can occur at any age and can be ...
Meghan, Campo, Nancy, Berliner
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Treatment of hemophagocytic lymphohistiocytosis
Current Opinion in Hematology, 2017Purpose of review Hemophagocytic lymphohistiocytosis (HLH) is a condition of uncontrolled immune activation with a high mortality rate. The recommended therapeutic guideline for HLH was published by the Histiocyte Society in 1994 and revised in 2004, which greatly improved the survival in patients with HLH.
Yini, Wang, Zhao, Wang
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Hemophagocytic Lymphohistiocytosis in the Elderly
The American Journal of the Medical Sciences, 2019Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of massive, dysregulated cytokine release and secondary multiorgan failure and is associated with high mortality. Primary HLH occurs predominately in infants and young children with a genetic predisposition.
Reyna, Altook +7 more
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Lamotrigine and hemophagocytic lymphohistiocytosis
Neurology, 2019Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening syndrome of hyperinflammatory responses with aberrant activation of lymphocytes and macrophages resulting in hypercytokinemia (a positive feedback loop between cytokines and immune cells, with highly elevated levels of various cytokines).1 The syndrome has multiple etiologies including
Kimford J, Meador, Barry E, Gidal
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Familial hemophagocytic lymphohistiocytosis
Diagnostic Cytopathology, 1988AbstractThe cytologic features of familial hemophagocytic lymphohistiocytosis in two infant siblings were reviewed and compared to the histopathologic features in the same cases. The cytologic features of familial hemophagocytic lymphohistiocytosis in imprint smears from the spleen, lymph nodes, and liver were distinct, with proliferation of benign ...
M F, Lachman, E H, Vogel, K, Kim
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