Results 81 to 90 of about 13,346 (189)

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra, Mahshad Ghoddusi, Mahsa Mottahedi, Maryam Albaji, Samira Kafan, Roya Saedpanah, Amir Shokri, Elham Nazar   +7 more
wiley   +1 more source

Hemophagocytic lymphohistiocytosis: A diagnostic conundrum

Journal of Pediatric Neurosciences, 2017
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation causing widespread inflammation and tissue destruction leading to multi-organ dysfunction and failure. Making the diagnosis of HLH could be quite challenging due to the broad range of presenting symptoms and their lack of specificity.
Grzybowski, Brittany, Vishwanath, Vijay A.   +1 more
openaire   +3 more sources

Adult cancer-related hemophagocytic lymphohistiocytosis – a challenging diagnosis: a case report

Journal of Medical Case Reports, 2017
Background Adult hemophagocytic lymphohistiocytosis is a secondary immunopathologic phenomenon, mainly secondary to malignancy, infection, or autoimmune disorders.
Michael A. Hust, Boris R. A. Blechacz, Diana L. Bonilla, Naval Daver, Cristhiam M. Rojas-Hernandez   +4 more
doaj   +1 more source

An Unusual Case of Classic Hodgkin Lymphoma With Strong Expression of B‐Cell Markers

International Journal of Laboratory Hematology, EarlyView.
Christopher Liwski, Sorin Selegean, Allam Shawwa, David M. Conrad   +3 more
wiley   +1 more source

Hemophagocytic Lymphohistiocytosis

New England Journal of Medicine
Konkol S, Killeen RB, Rai M.
europepmc   +8 more sources

UNC13D is the predominant causative gene with recurrent splicing mutations in Korean patients with familial hemophagocytic lymphohistiocytosis

Haematologica, 2010
Background Familial hemophagocytic lymphohistiocytosis is a fatal disease characterized by immune dysregulation from defective function of cytotoxic lymphocytes.
Hoi Soo Yoon, Hee-Jin Kim, Keon-Hee Yoo, Ki-Woong Sung, Hong-Hoe Koo, Hyoung Jin Kang, Hee Young Shin, Hyo Seop Ahn, Ji-Yoon Kim, Young-Tak Lim, Keun-Wook Bae, Ki-O Lee, Ji-Sook Shin, Seung-Tae Lee, Hae-Sun Chung, Sun-Hee Kim, Chan-Jeoung Park, Hyun-Sook Chi, Ho-Joon Im, Jong Jin Seo   +19 more
doaj   +1 more source

Extracorporeal Cytokine Hemadsorption for the Treatment of Severe Steroid Refractory Cytokine Release Syndrome Secondary to T‐Cell Immunotherapy for B‐Cell Malignancies: A Case Series

Hematological Oncology, Volume 44, Issue 4, July 2026.
Gianluca Cavallaro, Silvia Ferrari, Anna Pollastri, Elena Di Credico, Cristian Meli, Monica Rondi, Alessandro Putelli, Federico Lussana, Anna Grassi, Alessandro Rambaldi, Tino Martino Valetti, Ivano Riva, Giuseppe Gritti   +12 more
wiley   +1 more source

RASGRP1 Deficiency Manifesting as Severe Vasculopathy and Fatal Autoimmune Hemolytic Anemia

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Background RASGRP1 deficiency is a rare inborn error of immunity characterized by immunodeficiency, autoimmunity, and lymphoproliferation. Results We report a 5‐year‐old male with novel homozygous splice‐donor mutations in RASGRP1(c.1720+1G>A and c.1720+2T>C) who presented with severe vasculopathy (ischemic stroke and thrombosis), secondary ...
Kosar Asna Ashari, Bahareh Yaghmaie, Neda Pak, Mohammad Shahrooei, Vahid Ziaee, Nima Parvaneh   +5 more
wiley   +1 more source

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source