Results 81 to 90 of about 36,076 (253)

Concurrence of hemophagocytic lymphohistiocytosis and small-cell lung cancer in bone marrow: A case report and literature review

SAGE Open Medical Case Reports, 2022
Hemophagocytic lymphohistiocytosis is a rare and almost universally fatal disease in adults. A 60-year-old female patient presented to our hospital with a 3-day history of weakness and anorexia.
Wenyan Xu, Zhenxing Guo
doaj   +1 more source

Diagnostic guidelines for familial hemophagocytic lymphohistiocytosis revisited

Blood
Key Points • We present updated diagnostic criteria for FHL including revised clinical criteria and guidelines on genetic and cellular diagnostic assays.• HLH-2004 criteria (without NK-cell function) have significant validity (accuracy 99%) tested ...
J. Henter, E. Sieni, Julia Eriksson, Elisabet Bergsten, Ida Hed Myrberg, S. Canna, M. L. Coniglio, R. Cron, K. Kernan, Ashish R Kumar, Kai Lehmberg, F. Minoia, Ahmed Naqvi, Angelo Ravelli, Yongmin Tang, Matteo Bottai, Yenan T. Bryceson, A. Horne, Michael B. Jordan   +18 more
semanticscholar   +1 more source

Hemophagocytic lymphohistiocytosis after COVID-19 vaccination

Journal of Hematology & Oncology, 2021
Cases of thrombotic thrombocytopenia induced by coronavirus disease 2019 (COVID-19) vaccines have been reported recently. Herein, we describe the first case of another critical disorder, hemophagocytic lymphohistiocytosis (HLH), in a healthy individual ...
Liang V. Tang, Yu Hu
semanticscholar   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Hemophagocytic lymphohistiocytosis: a case series of a Brazilian institution

Revista Brasileira de Hematologia e Hemoterapia, 2014
Objective:To describe the clinical and laboratory presentation of hemophagocytic lymphohistiocytosis in children treated at a referral institution.Methods:A retrospective descriptive study was carried out of seven children diagnosed with hemophagocytic ...
Daniela Guimarães Rocha Ferreira, Paulo do Val Rezende, Mitiko Murao, Marcos Borato Viana, Benigna Maria de Oliveira   +4 more
doaj   +1 more source

Evidence-based diagnosis and treatment of macrophage activation syndrome in systemic juvenile idiopathic arthritis. [PDF]

, 2017
Background Macrophage activation syndrome (MAS) is a severe and potentially lethal complication of several inflammatory diseases but seems particularly linked to systemic juvenile idiopathic arthritis (sJIA).
Antón López, Jordi, Boom, V., Lahdenne, P., Quartier, Pierre, Ravelli, Angelo, Vastert, Sebastiaan J., Wulffraat, Nico   +6 more
core   +1 more source

Treatment-related hemophagocytic lymphohistiocytosis due to atezolizumab: a case report and review of the literature

Journal of Medical Case Reports, 2022
Background Immune checkpoint inhibitors avoid inhibition of T-cell responses, upregulating antitumor immune response. Moreover, a dysregulation with hyperactive immune response can be caused, some of them underdiagnosed.
J. Rubio-Perez, Á. Rodríguez-Perez, M. Díaz-Blázquez, V. Moreno-García, Manuel Dómine-Gómez   +4 more
semanticscholar   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Successfully performed video capsule endoscopy in an 8‐month‐old infant weighing 7.5 kg

JPGN Reports, EarlyView.
Abstract Video capsule endoscopy (VCE) is a well‐established diagnostic tool for examining the small bowel. Limited data exist on its use in infants. To our knowledge, we present the first detailed case of a successful PillCam®SB3‐VCE performed in an 8‐month‐old infant weighing 7.5 kg with suspected small bowel bleeding following allogeneic ...
Paul‐Christoph Zeisler, Robert Thimme, Ulrike Teufel‐Schaefer, Michael Schultheiß   +3 more
wiley   +1 more source

Epidemiological investigation of hemophagocytic lymphohistiocytosis in China

Orphanet Journal of Rare Diseases, 2021
Background Currently, most research on hemophagocytic lymphohistiocytosis (HLH) have focused on etiology and therapy, leaving few epidemiological reports. The published studies of China are mainly regional investigations.
S. Yao, Yini Wang, Yuan Sun, Li Liu, Rui Zhang, Jian-He Fang, R. Jin, Jiegen Yu, Fei Li, Jie Bai, Yun Zeng, Cheng Zhang, H. Tan, Fan Zhou, Yan Chen, Qiao-yun Zhang, Zhao Wang   +16 more
semanticscholar   +1 more source