Results 91 to 100 of about 36,076 (253)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children

Clinics, 2016
OBJECTIVE: Hemophagocytic lymphohistiocytosis in adults is largely underdiagnosed. To improve the rate and accuracy of diagnosis in adults, the clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis were analyzed in and compared ...
Zuojuan Zhang, Juandong Wang, Buqiang Ji, Tatiana von Bahr Greenwood, Yuan Zhang, Yongjing Wang, Dexiao Kong, Ai Li, Yang Jiang, Yanan Guo, Xiaoli Liu, Yingxue Wang, Aixia Dou, Nailin Li, Jan-Inge Henter, Guizhen Sun, Chengyun Zheng   +16 more
doaj   +1 more source

Acute hepatitis A infection‐associated hemophagocytic lymphohistiocytosis in adult presenting as impending acute liver failure: A case report and literature review

Clinical Case Reports, 2022
Hemophagocytic lymphohistiocytosis has been reported as a severe complication of various viral infections but unusual for the hepatitis A virus. We report a case of 25‐year‐old man with hepatitis A infection‐associated hemophagocytic lymphohistiocytosis ...
Panotpol Termsinsuk, Piyaporn Sirisanthiti   +1 more
doaj   +1 more source

Anaplasmosis-induced hemophagocytic lymphohistiocytosis

Proceedings, 2022
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening inflammatory syndrome of severe immune system activation. It is a diagnostic challenge with high morbidity and mortality. We present a case of HLH due to anaplasmosis infection.
M. de Jesus, A. López, J. Yabut, Stephanie Vu, M. Manne, L. Ibrahim, R. Mutneja   +6 more
semanticscholar   +1 more source

Incidence and Survival of Hemophagocytic Lymphohistiocytosis Over Two Decades: A Population‐Based Study

European Journal of Haematology, EarlyView.
ABSTRACT Adult hemophagocytic lymphohistiocytosis (HLH) is a rare, life‐threatening syndrome triggered by various conditions. A nationwide study of the incidence and outcomes of HLH in Denmark over 23 years (2000–2023) was performed. Adults (≥ 18 years) with HLH and triggering diseases were identified in the Danish National Patient Registry and/or the ...
Mads Okkels Birk Lorenzen, Martin Jensen, Rasmus Rask Kragh Jørgensen, Paw Jensen, Henrik Frederiksen, Dennis L. Hansen, Daniel El Fassi, Morten Nørgaard Andersen, Tarec Christoffer El‐Galaly   +8 more
wiley   +1 more source

Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature

Journal of Infection in Developing Countries, 2016
Hemophagocytic lymphohistiocytosis is a potentially fatal disorder resulting from excessive activation and non-malignant proliferation of T lymphocytes and macrophages.
Maria Scalzone, Antonio Ruggiero, Stefano Mastrangelo, Giovanna Trombatore, Vita Ridola, Palma Maurizi, Riccardo Riccardi   +6 more
doaj   +1 more source

Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib

International Journal of Infectious Diseases, 2020
JAK/STAT signaling plays a major role in the pathogenesis of secondary hemophagocytic lymphohistiocytosis. This case report on a critically ill patient with secondary hemophagocytic lymphohistiocytosis due to falciparum malaria treated successfully with ...
André Fuchs, Hans-Martin Orth, Ulrich Germing, Mustafa Kondakci, Martha Holtfreter, Torsten Feldt, Björn Erik-Ole Jensen, Dieter Häussinger   +7 more
doaj   +1 more source

Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis, cytomegalovirus viremia, and nontuberculous mycobacteria bacteremia in a patient with recently diagnosed AIDS

IDCases, 2022
A 30-year-old Honduran male with recently diagnosed AIDS presented with a 1-month history of worsening abdominal pain, diarrhea, and fever. Initial investigations were notable for Cytomegalovirus viremia and diffuse lymphadenopathy.
Benjamin Fogelson, Krupa Patel, Jared Spoons, Shawna Stephens, Megan Edwards   +4 more
doaj   +1 more source

A Rare Case of Hemophagocytic Lymphohistiocytosis of Unknown Etiology [PDF]

, 2017
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon cytokine storm syndrome marked which can cause high mortality. In adults, acquired HLH usually has an underlying infectious, autoimmune or malignant process that triggers the syndrome.
Damsker, Jason A., Friedenheim, Richard, Gagnon, Marie Helene, Micaily, Ida   +3 more
core   +1 more source

Diagnosing haemophagocytic syndrome [PDF]

, 2016
Haemophagocytic syndrome, or haemophagocytic lymphohistiocytosis (HLH), is a hyperinflammatory disorder characterised by uncontrolled activation of the immune system.
Ramanan, Athimalaipet V, Sen, Ethan S, Steward, Colin G   +2 more
core   +2 more sources