Results 51 to 60 of about 6,796 (202)

Severe Plasmodium vivax Malaria Complicated by Secondary Hemophagocytic Lymphohistiocytosis, Disseminated Intravascular Coagulation, and Acute Pancreatitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Plasmodium vivax (P. vivax) malaria, once regarded as a comparatively benign infection, is increasingly recognized as a cause of severe, potentially life‐threatening multisystem disease. Concurrent secondary hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and acute pancreatitis complicating P.
Tasnim Nafian, Md. Abul Kalam Azad, Khaled Mahbub Murshed, Kazi Ali Aftab, Rubayet Shahriar, Abdullah Al Faisal   +5 more
wiley   +1 more source

An Overlap of Erdheim–Chester Disease and Rosai–Dorfman Disease With Isolated Bone Lesions Presenting a Diagnostic Challenge: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Some of the rarest diseases with cell accumulation in different organs are histiocytoses. Since these diagnoses are uncommon, other differential diagnoses must be excluded. We report a case of a 42‐year‐old man with episodes of knee pain and fever.
Maris Tulk, Reet Kuuse, Maksim Zagura, Hazem M. M. Ali, Liis Vahesaar   +4 more
wiley   +1 more source

A Rare Case of Macrophage Activation Syndrome in a Neonate [PDF]

, 2015
Macrophage activation syndrome is excessive proliferation of macrophages associated with hemophagocytosis in bone marrow. It is characterized by fever >38.5oC for ≥7 days, splenomegaly, cytopenias (≥2 lineages), hypertriglyceridemia ...
Chandran, Rabindran, Parakh, Hemant, Rao, Madan Mohan, Murkhy, Rajnesh   +3 more
core   +1 more source

Frequency of Human Brucellosis Complications in West Asia: A Systematic Review and Meta‐Analysis

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
In 51.66% of the included studies in West Asia, the sample size was inadequate for at least half of the complications measured. ABSTRACT Background Brucellosis is a multi‐systemic zoonotic infection. The West Asia/Middle East region is an important global hotspot for brucellosis.
Aliasghar Fakhri‐Demeshghieh, Elnaz Rostamzaman, Fatemeh Sayareh, Amir Nikoukar, Faranak Farahani, Farniya Bakhtiary nia, Helia Sepahvand, Maryam Khaleghi, Mohammadsaeed Azamian, Mohammad Reza Shirzadi, Hesameddin Akbarein, Vahid Rahmanian   +11 more
wiley   +1 more source

Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning

Frontiers in Immunology, 2014
The human immune system depends on the activity of cytotoxic T lymphocytes, Natural Killer cells, and NKT cells in order to fight off a viral infection.
Elena eSieni, Valentina eCetica, Valentina eCetica, Yvonne eHackmann, Maria Luisa eConiglio, Martina eDa Ros, Benedetta eCiambotti, Daniela ePende, Gillian M Griffiths, Maurizio eArico   +9 more
doaj   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses

, 2013
Because immune responses simultaneously defend and injure the host, the immune system must be finely regulated to ensure the host's survival. Here, we have shown that when injected with high Toll-like receptor ligand doses or infected with lymphocytic ...
Kouji Matsushima, Yotsumoto, Satoshi, Axel Roers, Sawada, Kenichi, Hideaki Ohyagi, Sato, Taku, Liu, Jiajia, Hisaya Akiba, Kazutaka Kurabayashi, Matsushima, Kouji, Toshiaki Ohteki, Ohyagi, Hideaki, Ohteki, Toshiaki, Kenya Honda, Takahashi, Naoto, Onai, Nobuyuki, Naoto Takahashi, Roers, Axel, Kurabayashi, Kazutaka, Makoto Hirokawa, Satoshi Yotsumoto, Hosoi-Amaike, Mayuka, Honda, Kenya, Taku Sato, Atarashi, Koji, Werner Müller, Yagita, Hideo, Hideo Yagita, Kenichi Sawada, Koji Atarashi, Nobuyuki Onai, Müller, Werner; id_orcid, Akiba, Hisaya, Hirokawa, Makoto, Jiajia Liu, Mayuka Hosoi-Amaike   +35 more
core   +1 more source

The IL‐10/IL‐6 Ratio and the Risk Score: Two Cytokines‐Based Predictors for Malignancy‐Associated Hemophagocytic Lymphohistiocytosis in Adults (M‐HLHa)

American Journal of Hematology, Volume 101, Issue 9, Page 2214-2224, September 2026.
ABSTRACT The predictive value of cytokines (CK) for malignancy‐associated adult hemophagocytic lymphohistiocytosis (M‐HLHa) remains uncertain. We evaluated a cytokine‐based Risk Score (RS) and the IL‐10/IL‐6 Ratio to predict M‐HLHa. Adult patients (n = 112) from the French HLH cohort (NCT02113917) with complete data for nine key HLH related CK measured
Coralie Bloch, Stephanie Chhun, Nanthara Sritharan, Marine Gil, Raphael Lhote, Marouane Boubaya, Olivier Lambotte, David Launay, Claire Larroche, Estibaliz Lazaro, Francois Liffermann, Marc Michel, Jean‐Marie Michot, Pierre Morel, Louis Terriou, Geoffrey Urbansk, Jean‐Francois Viallard, Morgane Cheminant, Felipe Suarez, Yves Lepelletier, Geneviève de Saint Basile, Olivier Hermine, the French HLH Study Group, Coralie Bloch, Jean Philippe Jais, Francois Liffermann, Pierre Morel, Morgane Cheminant, Felipe Suarez, Olivier Hermine, Fabrice Bonnet, Pascal Godemer, Damaj Gandhi, Olivier Fain, Olivier Lambotte, David Launay, Louis Terriou, Claire Larroche, Estibaliz Lazaro, Jean‐Francois Viallard, Francois Liffermann, Olivier Lortholary, Marc Michel, Jean‐Marie Michot, Pierre Morel, Frederic Pene, Antoinette Perlat, Geoffrey Urbanski   +47 more
wiley   +1 more source

Construction and evaluation of a chronic arthritis animal model induced by persistent activation of toll‐like receptors via lipopolysaccharide stimulation

Animal Models and Experimental Medicine, Volume 9, Issue 9, Page 1795-1812, September 2026.
We constructed a novel systemic juvenile idiopathic arthritis mouse model (LC) by introducing sustained TLR4 activation into the collagen‐induced arthritis model. The LC model effectively recapitulates human sJIA‐like systemic inflammation while revealing a critical dissociation between systemic immune activation and joint damage.
Fengming Li, Qiang Luo, Xinglin Wu, Yuxiao Chen, Xuemei Tang   +4 more
wiley   +1 more source

Dengue-associated secondary HLH in a pediatric patient: a rare case from Indonesia [PDF]

Romanian Journal of Pediatrics
Background. Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal condition characterized by excessive immune activation and severe systemic inflammation, often leading to multiorgan dysfunction.
Windradini Rahvian Aridama, Marisa Setiawan, Arifoel Hajat, Paulus Budiono Notopuro   +3 more
doaj   +1 more source