Results 91 to 100 of about 68,267 (269)

High-levelexpression of functional recombinant human coagulation factor VII in insect cells [PDF]

: Recombinant coagulation factor VII (FVII) is used as a potential therapeutic intervention in hemophilia patients who produce antibodies against the coagulation factors.
AD Shapiro, Ali Jahanian Najafabadi, Amaneh Mohammadi Roushandeh, B Brenner, B Furie, BG Maick, CR Hay, DA Roth, DE Lynn, DR O’Reilly, G Bray, G Kemball-Cook, HJ Cha, I Nillson, KR Kim, Mahdi Edalati Fathabad, Mahdi Rouhbakhsh, Mahshid Mohammadipour, Mehryar Habibi Roudkenar, MK Miller, Mohamad Ali Shokrgozar, Mohamad Salimi, N Wajih, Nasser Masroori, R Halabian, R Toso, Raheleh Halabian, SM Ruiz, SM Wu, T Li, UK Laemmli   +30 more
core   +1 more source

A Psychometric Analysis of the Haemophilia Quality of Life Questionnaire for Adults Physical Health Subscale and Total Scores: Data From the Phase 3 XTEND‐1 Trial in Patients With Severe Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Bleeding episodes can impair physical functioning and cause chronic pain in haemophilia A. The Haemophilia Quality of Life Questionnaire for Adults (Haem‐A‐QoL) was administered in XTEND‐1; the Physical Health (PH) subscale evaluated Physical Health/Functioning. Aim To evaluate psychometric properties of Haem‐A‐QoL PH and estimate
Jérôme Msihid, Alfonso Iorio, Amanda Wilson, Nana Kragh, Lauren Nelson, Shanshan Qin, Annemieke Willemze   +6 more
wiley   +1 more source

Predicting Recovery After Joint Bleeding in Persons With Bleeding Disorders

Haemophilia, EarlyView.
ABSTRACT Introduction Joint bleeds are burdensome and recovery differs from bleed to bleed. Identifying predictors of recovery could enable personalized treatment and monitoring; aiming to prevent long‐term joint deterioration, and facilitate faster return to activities. Aim To identify predictors of time to recovery after joint bleeding in people with
Gijs Aertssen, Lize F. D. van Vulpen, Wouter Foppen, Flora H. P. van Leeuwen, Merel A. Timmer   +4 more
wiley   +1 more source

Association of inferior vena cava filter placement for venous thromboembolic disease and a contraindication to anticoagulation with 30-day mortality [PDF]

, 2018
Importance: Despite the absence of data from randomized clinical trials, professional societies recommend inferior vena cava (IVC) filters for patients with venous thromboembolic disease (VTE) and a contraindication to anticoagulation therapy.
Brown, David L, Novak, Eric, Saeed, Mohammed J, Turner, Tyson E   +3 more
core   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Hemophilia

Family medicine, 2018
Algorithms of hemostatic therapy of hemophilia disease are presented.The treatment is based onsubstitute therapy by blood clotting factorsand other hemostatic drugs. Schemes for calculationof the hemostaticdrug doses, intervals between the doses, and duration of treatment forthe mostincident manifestations of the hemorrhagic syndrome arepresented ...
null С. В. Видиборець, null Ю. Ю. Дерпак, null Ю. Ю. Попович   +2 more
openaire   +2 more sources

Inherited Bleeding Disorders in Pregnancy: Obstetric Management and Outcomes From a Tertiary Care Centre

Haemophilia, EarlyView.
ABSTRACT Objective This study aimed to evaluate the obstetric management, complications and clinical characteristics of pregnant women diagnosed with hereditary coagulation factor deficiencies at a tertiary obstetric centre over a 10‐year period. Methods We retrospectively reviewed a total of 19 pregnancies in 17 women with hereditary coagulation ...
Melis Altug Inan, Bilge Kapudere, Hanne Bulat Cim, Abdulkadir Turgut   +3 more
wiley   +1 more source

Adherence to Clotting Factor Prophylaxis in Adolescent and Adult Males With Haemophilia

Haemophilia, EarlyView.
ABSTRACT Introduction Clotting factor prophylaxis remains the most prescribed standard‐of‐care treatment for people with haemophilia (PwH). Prophylaxis prevents bleeds, joint damage, and improves quality of life (QoL). Its success depends on treatment adherence, consisting of socioeconomic, behavioural, and disease‐ or therapy‐related factors.
Nathália Martins Beserra, Ricardo Mesquita Camelo, Alice Oliver Rosa Sacramento, Eliziane Souza Nascimento, Rosângela Pinheiro Gonçalves Machado, Clarissa Maria Gonçalves Machado, Suzzy Maria Carvalho Dantas, Samuel Gonçalves Machado da Rocha, Luany Elvira Mesquita Carvalho, Romélia Pinheiro Gonçalves Lemes   +9 more
wiley   +1 more source

The Health-Related Quality of Life scores and joint health in children and young adults with hemophilia

The Turkish Journal of Pediatrics
Background. Patients with hemophilia should be evaluated for joint health and overall health in their visits. The aims of this study were to evaluate joint health and health-related quality of life (HRQoL) in patients with mild, moderate, and severe ...
Buse Günyel, Mesut Bulakçı, Gamze Başkent, Ayşegül Ünüvar   +3 more
doaj   +1 more source

Factors Influencing Sport‐Induced Bleeding in Patients With Haemophilia Without Inhibitors: A Single Centre Retrospective Study of People Born in the 2000s

Haemophilia, EarlyView.
ABSTRACT Introduction Recent advances in prophylaxis with clotting factor concentrates have enabled people with haemophilia (PwH) to participate in high‐intensity exercises; however, this does not preclude them from sports‐induced bleeding (SIB). Aim To investigate factors influencing the recent occurrence of SIB among PwH.
Rie Shirayama, Takuma Ito, Tetsuji Sato, Takayuki Hoshina   +3 more
wiley   +1 more source