Results 101 to 110 of about 68,267 (269)
Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice [PDF]
, 2006 Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A +4 more
core
Haemophilia, EarlyView.ABSTRACT Introduction The therapeutic landscape for patients with haemophilia A (PwHA) is rapidly evolving with the introduction of extended half‐life FVIII (EHL‐FVIII) and non‐FVIII therapies that mimic FVIII, such as emicizumab (EMI). Monitoring non‐factor therapies in the laboratory poses challenges; however, the thrombin generation assay (TGA) can ...
Jessica Garcia +4 more
wiley +1 more source
Cyclosporine treatment of acquired hemophilia due to factor VIII antibodies [PDF]
, 2000 Acquired hemophilia, caused by autoantibodies against coagulation factor VIII, is usually treated with steroids, cyclophosphamide, intravenous gammaglobulins and sporadically other drugs.
Baele, Gaston +2 more
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Haemophilia, EarlyView.ABSTRACT Introduction Current guidelines recommend prophylaxis for patients with non‐severe haemophilia with severe bleeding phenotype (SBPT) but there is no consensus how to define a SBPT and when to recommend prophylaxis in patients with non‐severe haemophilia. Method A Delphi consensus procedure among the members of the Standing Committee Hemophilia
Christian Pfrepper +10 more
wiley +1 more source
Hemoaction game: an educational step to improve hemophilia children and nurses self-efficacy
Journal of Advances in Medical Education and Professionalism, 2016 As hemophilia is a chronic bleeding disease and can interfere with daily performance of children, these children require continuous training to prevent bleeding and take timely action (1).
NOOASHIN BEHESHTIPOOR +4 more
doaj
Haemophilia, EarlyView.ABSTRACT Introduction Valoctocogene roxaparvovec, an adeno‐associated virus (AAV)‐based gene therapy, enables endogenous factor VIII (FVIII) expression in patients with severe hemophilia A without the need for regular FVIII infusions. Long‐term follow‐up assesses durability, safety, and immune‐related challenges following gene therapy.
Kerstin Herbst +8 more
wiley +1 more source
Sociodemographic and clinical characteristics of persons who experienced spontaneous hepatitis C viral clearance. [PDF]
, 2019 BackgroundIn the United States Hepatitis C virus (HCV) viral clearance is estimated to range between 20 and 30%. The objective of this study was to estimate the frequency of HCV clearance and identify correlates of viral clearance among patients newly ...
Baik, Yeonsoo +8 more
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Haemophilia, EarlyView.ABSTRACT Introduction Despite available prophylactic therapies for haemophilia A, breakthrough bleeding and consequent pain and joint damage still occur. Aim To provide insights into the unmet treatment needs of people with moderate‐to‐severe haemophilia A in the US.
Allison P. Wheeler +14 more
wiley +1 more source
Clinical Features And Laboratory Patterns In A Cohort Of Consecutive Argentinian Patients With Von Willebrand's Disease [PDF]
, 2001 Background and Objectives. von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. Design and Methods.
Blanco, A. N. +6 more
core
Maximum Likelihood Estimation of the Multivariate Normal Mixture Model [PDF]
The Hessian of the multivariate normal mixture model is derived, and estimators of the information matrix are obtained, thus enabling consistent estimation of all parameters and their precisions.
Boldea, Otilia, Magnus, Jan R.
core +1 more source