Results 191 to 200 of about 118,583,499 (297)

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 914-929, October 2026.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Peripheral Seal Composite Barrier (PSCB) for Management of Palatal Donor Sites in Mucogingival Surgery: A Randomized Clinical Trial

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objectives Management of the palatal donor site following periodontal plastic surgery remains challenging because of postoperative pain, bleeding, and patient discomfort. This study aimed to evaluate the efficacy of a chairside‐fabricated composite barrier in reducing morbidity at the palatal donor site.
Moein Khojaste, Farid Shiezadeh, Zahra Moslehitabar   +2 more
wiley   +1 more source

Tissue Factor/Factor XIa Dual-activated Thrombin Generation is Able to Reliably Measure Thrombin Generation at All Hemophilia A Disease Severities. [PDF]

TH Open
van de Berg TW, Heinzmann A, Thomassen S, Schols SEM, Heubel-Moenen FCJI, van Es N, Rosendaal FR, Gouw S, Hackeng TM, Beckers EAM.   +9 more
europepmc   +1 more source

Factor VIII inhibitors demonstrate type I or type II kinetics in high‐titre alloantibodies and autoantibodies

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
The inhibitor kinetics type cannot be used by itself to determine auto‐ versus allo‐anti‐FVIII antibody type. To characterise inhibitor kinetics in inherited haemophilia A (HA) and acquired haemophilia A (AHA) patients in our centre, results show that inhibitors for both HA alloantibodies and AHA autoantibodies may exhibit either type I or type II ...
Cuicui Qiao, Jie Wang, Tiantian Wang, Hehe Wang, Yingfang Pan, Wei Liu, Yan Cheng, Feng Xue, Man‐Chiu Poon, Xinsheng Zhang, Yunhai Fang   +10 more
wiley   +1 more source

Increased gene therapy efficacy through the use of extended half-life clotting factors. [PDF]

Blood Adv
De Wolf D, Nguyen PA, Nair N, Gao F, Bheemsetty VA, Samara-Kuko E, Chuah MK, VandenDriessche T.   +7 more
europepmc   +1 more source

Advancements in CRISPR-based <i>in vivo</i> gene therapy for hemophilia. [PDF]

Front Genome Ed
Zhang X, Xu K, Zou S, Zhu Z, Teng S, Huang P.   +5 more
europepmc   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Doing more with less in hemophilia B gene therapy. [PDF]

Blood Adv
Miesbach W.
europepmc   +1 more source

Acquired Hemophilia

Turkish Journal of Hematology, 2014
openaire   +3 more sources

Time‐ and Temperature‐Dependent Response of Acquired FV Inhibitors: Implications for Laboratory Diagnosis and Clinical Management

Journal of Clinical Laboratory Analysis, Volume 40, Issue 20, October 2026.
This in vitro workflow illustrates the time‐and temperature‐dependent behavior of acquired FV inhibitors. Patient plasma was centrifuged and serially diluted, followed by parallel incubation at room temperature and 37°C. Serial measurements of APTT mixing test and residual FV activity were recorded across incubation time points to monitor inhibitor ...
Lihua Zhang, Mingjie Li, Zhiqiang Xie, Junxiang Yao, Yingping Cao, Lihui Chen, Meihua Wang   +6 more
wiley   +1 more source