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A ten-week-old male Golden retriever puppy was presented with severe hyperesthesia, mild neurological deficits and episcleral bleeding. Clotting times showed a normal prothrombin time (PT) and prolonged activated partial thromboplastin time (aPPT ...
Charlotte Lubbers+3 more
doaj +1 more source
In Vivo Measurement of Blood Clot Mechanics from Computational Fluid Dynamics based on Intravital Microscopy Images [PDF]
Ischemia leading to heart attacks and strokes is the major cause of deaths in the world. Whether an occlusion occurs or not, depends on the ability of a growing thrombus to resist forces exerted on its structure. This manuscript provides the first known in vivo measurement of the stresses that clots can withstand, before yielding to the surrounding ...
arxiv +1 more source
Mild hemophilia A (HA), defined by clinical features and factor VIII coagulant activity (FVIII:C) between 0.05 and 0.40 IU mL(-1), is characteristically distinct from severe HA. Indeed, although the molecular characterization of mild HA has permitted the identification of specific underlying mutations, its clinical phenotype is strikingly different ...
Franchini M+2 more
openaire +3 more sources
Hemophilia management: Huge impact of a tiny difference
Hemophilia A and B are inherited X‐linked disorders of hemostasis, associated with an increased bleeding tendency. Patients with severe hemophilia have undetectable clotting factor levels and experience spontaneous bleeds.
Fabienne Kloosterman+5 more
doaj +1 more source
"Prevalence of inhibitors in a population of 1280 Hemophilia A patients in Iran " [PDF]
Development of inhibitor to factor VIII is the most serious complication of hemophilia therapy. To determine the prevalence of inhibitors in Iran hemophilia A patients exposed to blood products, 1280 hemophilia A patients (age range 9 months-84 years ...
Sharifian R+6 more
doaj +2 more sources
Ultrasound Detection of Subquadricipital Recess Distension [PDF]
Joint bleeding is a common condition for people with hemophilia and, if untreated, can result in hemophilic arthropathy. Ultrasound imaging has recently emerged as an effective tool to diagnose joint recess distension caused by joint bleeding. However, no computer-aided diagnosis tool exists to support the practitioner in the diagnosis process.
arxiv
Perfil clínico e epidemiológico de crianças e adolescentes com hemofilia em um centro de referência
OBJECTIVE: To identify clinical and epidemiological data of children and adolescents with hemophilia followed at the Center for Hematology and Hemotherapy of Piaui, characterizing them in terms of age, place of residence, type, severity, main ...
Marcela Bezerra Marques+1 more
doaj +1 more source
Background: Hemophilia A, an X-linked recessive disorder of coagulation, caused due to the deficiency of coagulation factor-VIII and hemophilia-B caused due to the deficiency of factor-IX cause spontaneous and traumatic bleeding episodes, leading to ...
Sujeet Mishra+3 more
doaj +1 more source
Bleeding Patterns among Severe Hemophilia A and B Patients in West Java
Background: The clinical manifestations of hemophilia A (HA) and hemophilia B (HB)are quite similar; however, the bleeding characteristics of these two hemophilia types have been reported to be different. This study aimed to explore the bleeding patterns
Muhammad Mufakkirul Islam+2 more
doaj +1 more source