Results 41 to 50 of about 118,583,499 (297)

Assessing policy and operational barriers to tranexamic acid utilization in treating postpartum hemorrhage in Kano, Lagos, and Niger states

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study explores the barriers to the use of tranexamic acid (TXA) for the management of postpartum hemorrhage (PPH) and provides recommendations to improve its use. Methods We conducted a mixed‐methods assessment involving 229 healthcare professionals in Kano, Lagos, and Niger States of Nigeria.
Chukwunonso Nwaokorie, Aisha Abdullahi, Naanma Kangkum, Valentine Amasiatu, Eric Aigbogun, Uchenna Igbokwe   +5 more
wiley   +1 more source

Report on the diagnosis and treatment of hemophilia in China (Version 2024)

LabMed Discovery
Hemophilia is a hemorrhagic disease caused by a lack of clotting factors due to genetic mutations, and is a representative of rare diseases. The prevalence rate of hemophilia is about 2.73/100,000–3.09/100,000 in China, and the absolute number of ...
Feng Xue, Jing Dai, Li-xia Chen, Wei Liu, Hou-qiang Zhang, Run-hui Wu, Jing Sun, Xin-sheng Zhang, Jing-sheng Wu, Yong-qiang Zhao, Xue-feng Wang, Ren-chi Yang   +11 more
doaj   +1 more source

Establishing the prevalence and prevalence at birth of hemophilia in males : a meta-analytic approach using national registries

, 2019
Background: The large observed variability in hemophilia prevalence prevents robust estimation of burden of disease. Objective: To estimate the prevalence and prevalence at birth of hemophilia and the associated life expectancy disadvantage ...
Chambost, H., Stonebraker, Jeffrey, Makris, Michael, Makris, M., Germini, F., Coffin, D., Germini, Federico, Herr, C., Stonebraker, J.S., Coffin, Donna, Chambost, Hervé, Iorio, A., Iorio, Alfonso, Herr, Christine, Germini F., Chambost H., Byams V., Iorio A., Makris M., El-Ekiaby M., O'Hara J., Pierce G. F., Coffin D., Stonebraker J. S., Weill A., Herr C.   +25 more
core   +2 more sources

Recombinant activated factor VIIa for severe postpartum hemorrhage in Africa: Evidence, appropriate use, and research priorities—A narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Postpartum hemorrhage (PPH) accounts for 30%–50% of maternal mortality in Africa and occurs in the context of pre‐existing anemia, limited blood product availability, delayed recognition, and constrained referral systems. Although bundle‐based care (E‐MOTIVE), early tranexamic acid (TXA), and uterotonics have substantially improved outcomes, a
Johnny Mahlangu, Haroun Rhemtula, Jarrod Zamparini, Lawrence Chauke   +3 more
wiley   +1 more source

Understanding the Concept of Self‐Performed Ultrasound: A Scoping Review

Journal of Ultrasound in Medicine, EarlyView.
Self‐performed ultrasound is an emerging technology that facilitates adept self‐scans in untrained hands. Inspired by self‐performed imaging in space for more prompt diagnosis and therapy, it has the potential to accurately monitor chronic conditions remotely. However, the lack of supervision and physical restraints can hinder its usability.
Vy Do, Anson Chau, Elio Arruzza, Nayana Parange   +3 more
wiley   +1 more source

Shaping hemophilia care: lessons and legacy of the SIPPET trial after 10 years

Research and Practice in Thrombosis and Haemostasis
The advent of nonreplacement therapies, such as emicizumab, has contributed to a marked reduction of the observed incidence of factor (F)VIII inhibitors in patients with severe hemophilia A.
Flora Peyvandi, Roberta Palla, Isabella Garagiola, Pier Mannuccio Mannucci   +3 more
doaj   +1 more source

Spontaneous spinal epidural hematoma in a known case of hemophilia a managed conservatively: A rare case report

Journal of Applied Hematology, 2021
Spontaneous spinal extradural hematomas are rarely attributed to hemophilia. When it occurs, magnetic resonance imaging (MRI) best establishes the diagnosis that should prompt immediate medical or surgical management.
Ashish Acharya, Ravindra Kumar Bind, Sarvpreet Singh Grewal, Paul Sudhakar John   +3 more
doaj   +1 more source

Patients with obesity have a higher risk of periprosthetic joint infection and more frequent polymicrobial infections after knee arthroplasty: A nationwide register‐based study from Denmark

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare the 2‐year incidence of (1) revision due to periprosthetic joint infection (PJI) and (2) all‐cause revision after primary knee arthroplasty (KA) in patients with/without obesity and to compare the microbial profiles in early (≤ 90 days) and late (91–730 days) PJI.
Saber M. Aljuboori, Espen Jimenez‐Solem, Henrik Calum, Robin Christensen, Søren Overgaard   +4 more
wiley   +1 more source

Emicizumab Associated Rhabdomyolysis in Hemophilia A

Clinical Hematology International, 2020
Emicizumab is increasingly the front-line treatment for patients with Hemophilia A with or without inhibitors. Rhabdomyolysis is a syndrome of muscle necrosis and release of intracellular muscle constituents into the circulation.
Joseph A. Wilson, Stephanie Hayden, Alexander Asamoah, Vivek R. Sharma, David C. Jennings, Ashok B. Raj   +5 more
doaj   +1 more source

Specific functional knee phenotypes are associated with increased osteoarthritis progression: A ≥10‐year longitudinal study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate osteoarthritis (OA) progression across functional knee phenotypes (FKPs) over a follow‐up period of ≥10 years. Methods This retrospective longitudinal study included 388 patients (764 knees) with healthy knees or early OA (Kellgren–Lawrence grade ≤1) at baseline and a minimum follow‐up of 10 years.
Sang Jun Song, Hyo Beom Lee, Cheol Hee Park   +2 more
wiley   +1 more source